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54 条记录 (耗时 0.04 秒)

    Apparatus and method for dispensing foam
    1.
    发明授权
    Apparatus and method for dispensing foam 有权
    用于分配泡沫的装置和方法

    公开(公告)号：US08122917B2

    公开(公告)日：2012-02-28

    申请号：US12923209

    申请日：2010-09-09

    申请人： Anthony David Harman ,  David Dakin Iowerth Wright ,  Jam Wilem Marinus Mijers ,  Stuart Brian William Kay ,  Christopher John Hurlstone ,  Julina Richard Dixon ,  Andrew Gordon Pocock ,  Brendan Hogan

    发明人： Anthony David Harman ,  David Dakin Iowerth Wright ,  Jam Wilem Marinus Mijers ,  Stuart Brian William Kay ,  Christopher John Hurlstone ,  Julina Richard Dixon ,  Andrew Gordon Pocock ,  Brendan Hogan

    IPC分类号： B65B1/04

    CPC分类号： B65D83/205 ,  B65B3/22 ,  B65D83/7532 ,  B65D83/756

    摘要： A foam transfer device is described, for use with aerosol canister apparatus for producing a sclerosant foam for the treatment of, inter alia, varicose veins. The device enables diversion of an initial quantity of below-specification foam from the canister to waste, e.g. to an integral waste chamber, before dispensing a further quantity of foam for use in treatment. The switching of the flow from the waste chamber to a different outlet for use is accomplished without interrupting the flow from the aerosol canister since this would cause the foam to drop below specification again. The waste chamber may be transparent so that the foam entering it can be observed and a decision made by a user when to stop diverting foam to waste. Alternatively, the foam may be diverted automatically e.g. when a set time has elapsed or a set volume of foam dispensed. The foam for use is normally dispensed into a syringe for subsequent injection into a varicose vein of a patient.

    摘要翻译： 描述了泡沫转移装置，用于产生用于治疗静脉曲张的硬化泡沫的气溶胶罐装置。 该装置能够将来自罐的初始数量低于规格的泡沫转移到废物，例如。 在分配更多量的泡沫以用于治疗之前，到整体的废物室。 在不中断来自气溶胶罐的流动的情况下，将来自废物室的流量切换到不同的出口以进行使用，因为这将导致泡沫再次降低到规格以下。 废物室可以是透明的，使得可以观察到进入其中的泡沫，并且由用户决定何时停止将泡沫转移到废物中。 或者，泡沫可以自动转移，例如 当设定的时间过去或一定量的泡沫分配时。 使用的泡沫通常分配到注射器中，以便随后注射到患者的静脉曲张静脉中。

    Dual specificity antibodies and methods of making and using
    2.
    发明授权
    Dual specificity antibodies and methods of making and using 有权
    双重特异性抗体及其制备和使用方法

    公开(公告)号：US07491516B2

    公开(公告)日：2009-02-17

    申请号：US09894550

    申请日：2001-06-28

    申请人： Albert Collinson ,  George Avgerinos ,  Richard Dixon ,  Tariq Ghayur ,  Zehra Kaymakcalan

    发明人： Albert Collinson ,  George Avgerinos ,  Richard Dixon ,  Tariq Ghayur ,  Zehra Kaymakcalan

    IPC分类号： C12P21/08 ,  C12P21/04 ,  C07K16/00 ,  A61K39/00 ,  A61K39/395

    CPC分类号： C07K16/245 ,  A61K47/6845 ,  A61K2039/505 ,  C07K14/545 ,  C07K16/46 ,  C07K16/468 ,  C07K2317/10 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76 ,  G01N33/6869

    摘要： Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1α and IL-1β and neutralize IL-1α and IL-1β activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1α and IL-1β ) and for inhibiting the activity of the antigens, e.g., in a human subject suffering from a disorder in which IL-1α and/or IL-1β activity is detrimental.

    摘要翻译： 提供了对两种不同但结构相关抗原具有双重特异性的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对IL-1α和IL-1β具有双重特异性，并在体外和体内中和IL-1α和IL-1β活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测两种不同但结构相关的抗原（例如IL-1α和IL-1β），并且用于抑制抗原的活性，例如在患有疾病的人类受试者中 其中IL-1α和/或IL-1β活性是有害的。

    Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
    3.
    发明申请
    Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof 审中-公开
    内皮素受体拮抗剂与磷酸二酯酶5抑制剂的组合及其用途

    公开(公告)号：US20060205733A1

    公开(公告)日：2006-09-14

    申请号：US11211099

    申请日：2005-08-25

    申请人： Richard Dixon ,  Donald Keyser

    发明人： Richard Dixon ,  Donald Keyser

    IPC分类号： A61K31/519 ,  A61K31/513 ,  A61K31/4745 ,  A61K31/42 ,  A61K31/4025

    CPC分类号： A61K31/505 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates generally to combination therapies comprising an endothelin A receptor (ETA) antagonist and a phosphodiesterase 5 (PDE5) inhibitor, pharmaceutical compositions comprising ETA antagonist and PDE5 inhibitor and methods of treating various disorders comprising administering an ETA antagonist and a PDE5 inhibitor. In particular, the combination therapies and pharmaceutical compositions are useful for the treatment and/or prevention of cardiac disorders such as pulmonary arterial hypertension (PAH).

    摘要翻译： 本发明一般涉及包含内皮素A受体（ETA）拮抗剂和磷酸二酯酶5（PDE5）抑制剂的组合疗法，包含ETA拮抗剂和PDE5抑制剂的药物组合物和 治疗各种疾病的方法包括施用ETA拮抗剂和PDE5抑制剂。 特别地，组合疗法和药物组合物可用于治疗和/或预防心脏疾病如肺动脉高压（PAH）。

    Plant fatty acid amide hydrolases
    7.
    发明申请
    Plant fatty acid amide hydrolases 失效
    植物脂肪酸酰胺水解酶

    公开(公告)号：US20050028233A1

    公开(公告)日：2005-02-03

    申请号：US10862063

    申请日：2004-06-04

    申请人： Kent Chapman ,  Rhidaya Shrestha ,  Elison Blancaflor ,  Richard Dixon

    发明人： Kent Chapman ,  Rhidaya Shrestha ,  Elison Blancaflor ,  Richard Dixon

    IPC分类号： A01H1/00 ,  C07H21/04 ,  C12N9/80 ,  C12N15/82

    CPC分类号： C12N9/80 ,  C12N15/8247 ,  C12N15/8271

    摘要： The invention provides plant fatty acid amide hydrolase (FAAH) coding sequences. Also provided are constructs comprising these sequences, plants transformed therewith and methods of use thereof. The invention allows the modification of plants for FAAH activity and N-Acylethanolamine levels. Such modification may be used to produce plants that are improved with respect to growth, seed germination, pathogen response and stress tolerance.

    摘要翻译： 本发明提供植物脂肪酸酰胺水解酶（FAAH）编码序列。 还提供了包含这些序列的构建体，用其转化的植物及其使用方法。 本发明允许植物修饰FAAH活性和N-亚苄醇胺水平。 这种修饰可用于产生相对于生长，种子发芽，病原体应答和胁迫耐受性改进的植物。

    Reinforced support element for wall panel arrangement
    8.
    发明授权
    Reinforced support element for wall panel arrangement 有权
    用于墙板布置的加强支撑元件

    公开(公告)号：US06748997B2

    公开(公告)日：2004-06-15

    申请号：US10134043

    申请日：2002-04-26

    申请人： Nicholas Fricano ,  Richard Dixon ,  Mark R. Smith ,  Jonathan R. DeYoung ,  Scott J. Leenstra

    发明人： Nicholas Fricano ,  Richard Dixon ,  Mark R. Smith ,  Jonathan R. DeYoung ,  Scott J. Leenstra

    IPC分类号： A47G500

    CPC分类号： E04B2/7437 ,  E04B2002/7479 ,  E04B2002/7487

    摘要： An upright connector or support post usable in a space-dividing wall panel system formed from serially connected panel assemblies. The post includes a plurality of openings disposed in vertically spaced relation with one another which receive load-bearing elements such as hangers or hooks typically associated with furniture components. Dimples or deformations extend transversely along the upper and lower edges of the openings and provide increased strength at the attachment points along the post.

    摘要翻译： 可用于由串联连接的面板组件形成的空间分隔壁面板系统中的直立连接器或支撑柱。 该柱包括彼此垂直间隔开设置的多个开口，其接收承载元件，例如通常与家具部件相关联的吊架或钩。 凹槽或变形沿开口的上边缘和下边缘横向延伸，并在沿柱的附着点处提供增强的强度。