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公开(公告)号：US20150158929A1
公开(公告)日：2015-06-11
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US20130017997A1
公开(公告)日：2013-01-17
申请号：US13365166
申请日：2012-02-02
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
CPC分类号： C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US10421798B2
公开(公告)日：2019-09-24
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Volker Schellenberger , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
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公开(公告)号：US20100074901A1
公开(公告)日：2010-03-25
申请号：US12251518
申请日：2008-10-15
申请人： Marc Hubert Mercken , Jacqueline M. Benson , Sun-Yung S. Jung , Haiyan Jiang , Gopalan Raghunathan , Lionella Borozdina-Birch
发明人： Marc Hubert Mercken , Jacqueline M. Benson , Sun-Yung S. Jung , Haiyan Jiang , Gopalan Raghunathan , Lionella Borozdina-Birch
IPC分类号： A61K39/395 , G01N33/567 , C12P21/06 , C12N5/00 , C12N5/02 , C12N1/00 , C07K16/18 , C07H21/04 , C12P21/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to at least one novel human anti-amyloid antibody, including isolated nucleic acids that encode at least one anti-amyloid antibody, amyloid, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
摘要翻译： 本发明涉及至少一种新的人抗淀粉样蛋白抗体，包括编码至少一种抗淀粉样蛋白抗体，淀粉样蛋白，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用方法，包括 治疗组合物，方法和装置。
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公开(公告)号：US20120027743A1
公开(公告)日：2012-02-02
申请号：US13127461
申请日：2009-11-03
申请人： Haiyan Jiang , Tongyao Liu , Xin Zhang
发明人： Haiyan Jiang , Tongyao Liu , Xin Zhang
CPC分类号： C07K14/755 , A61K9/0019 , A61K38/00 , C12N9/6437 , C12N9/644 , C12Y304/21021 , C12Y304/21022
摘要： The present invention is directed to a method for the treatment of hemophilia.
摘要翻译： 本发明涉及一种治疗血友病的方法。
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公开(公告)号：US20120269817A1
公开(公告)日：2012-10-25
申请号：US13057728
申请日：2009-08-04
申请人： Zhuozhi Wang , John E. Murphy , Junliang Pan , Haiyan Jiang , Bing Liu
发明人： Zhuozhi Wang , John E. Murphy , Junliang Pan , Haiyan Jiang , Bing Liu
IPC分类号： A61K39/395 , C12P21/08 , C12N15/13 , C07K16/18 , A61P7/04
摘要： Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.
摘要翻译： 提供了结合人组织因子途径抑制剂（TFPI）的分离的单克隆抗体和编码它们的分离的核酸分子。 还提供了包含抗TFPI单克隆抗体的药物组合物和通过施用抗体治疗缺血或凝血缺陷的方法。 还提供了产生抗体的方法。
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