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公开(公告)号：US5587302A
公开(公告)日：1996-12-24
申请号：US462158
申请日：1990-01-08
IPC分类号： A61K38/00 , A61P43/00 , C07K14/54 , C07K16/24 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/91 , C12N15/12 , C12N15/63
CPC分类号： C07K16/244 , C07K14/5425 , A61K38/00
摘要： The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-responsive cells. Even more particularly, the present invention relates to the helper T cell growth factor P40, pharmaceutical compositions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for inducing the proliferation of helper T cells as well as IL3- and Il4-responsive cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.
摘要翻译： 本发明一般涉及T细胞生长因子。 更具体地，本发明涉及一种T细胞生长因子，其包含支持辅助性T细胞的白细胞介素2-和白细胞介素4非依赖性生长的糖蛋白，特别是来自鼠源和人来源，并且还能够增强IL3-或 IL4反应细胞。 更具体地，本发明涉及辅助性T细胞生长因子P40，其药物组合物，其抗体及其重组DNA克隆。 本发明还考虑了一种诱导辅助性T细胞以及IL3和II4反应性细胞增殖的方法。 本文考虑的辅助T细胞生长因子可用于单独或与IL3或IL4组合在免疫系统中刺激特异性细胞。
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公开(公告)号：US5157112A
公开(公告)日：1992-10-20
申请号：US408155
申请日：1989-09-15
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61P37/00 , A61P37/04 , C07H21/00 , C07H21/04 , C07K1/20 , C07K9/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/475 , C07K14/52 , C07K14/54 , C07K16/00 , C07K16/22 , C07K16/24 , C07K19/00 , C12N1/21 , C12N15/09 , C12N15/24 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K14/5425 , C07K16/244 , A61K38/00 , Y10S530/808 , Y10S930/14 , Y10S930/141
摘要： The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-responsive cells. Even more particularly, the present inventin relates to the helper T cell growth factor P40, pharmaceutical compositions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for inducing the proliferation of helper T cells as well as IL3- and Il4-responsive cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.
摘要翻译： 本发明一般涉及T细胞生长因子。 更具体地，本发明涉及一种T细胞生长因子，其包含支持辅助性T细胞的白细胞介素2-和白细胞介素4非依赖性生长的糖蛋白，特别是来自鼠源和人来源，并且还能够增强IL3-或 IL4反应细胞。 更具体地，本发明涉及辅助性T细胞生长因子P40，其药物组合物，抗体及其重组DNA克隆。 本发明还考虑了一种诱导辅助性T细胞以及IL3和II4反应性细胞增殖的方法。 本文考虑的辅助T细胞生长因子可用于单独或与IL3或IL4组合在免疫系统中刺激特异性细胞。
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公开(公告)号：US5750377A
公开(公告)日：1998-05-12
申请号：US447805
申请日：1995-05-23
IPC分类号： A61K38/00 , A61P43/00 , C07K14/54 , C07K16/24 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/91 , C07K1/18 , C07K1/20
CPC分类号： C07K16/244 , C07K14/5425 , A61K38/00
摘要： The present invention relates generally to a T cell growth factor. More particularly, the present invention relates to a T cell growth factor which comprises a glycoprotein which supports interleukin 2- and interleukin 4-independent growth of helper T cells especially from murine and human sources and further which is capable of augmenting proliferation of IL3- or IL4-responsive cells. Even more particularly, the present invention relates to the helper T cell growth factor P40, pharmaceutical compositions thereof, antibodies thereto and recombinant DNA clones thereof. The present invention also contemplates a method for inducing the proliferation of helper T cells as well as IL3- and Il4-responsive cells. The helper T cells growth factor contemplated herein is useful in the stimulation of specific cells in the immune system, either alone or in combination with IL3 or IL4.
摘要翻译： 本发明一般涉及T细胞生长因子。 更具体地，本发明涉及一种T细胞生长因子，其包含支持辅助性T细胞的白细胞介素2-和白细胞介素4非依赖性生长的糖蛋白，特别是来自鼠源和人来源，并且还能够增强IL3-或 IL4反应细胞。 更具体地，本发明涉及辅助性T细胞生长因子P40，其药物组合物，其抗体及其重组DNA克隆。 本发明还考虑了一种诱导辅助性T细胞以及IL3和II4反应性细胞增殖的方法。 本文考虑的辅助T细胞生长因子可用于单独或与IL3或IL4组合在免疫系统中刺激特异性细胞。
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公开(公告)号：US5180678A
公开(公告)日：1993-01-19
申请号：US832192
申请日：1992-02-06
IPC分类号： C07K14/705 , A61K38/00 , C07K1/00 , C07K14/00 , C07K14/715 , C12P21/00 , G01N33/53
CPC分类号： C07K14/7155 , A61K38/00
摘要： The invention relates to substantially pure interleukin 9 receptor molecules and the use thereof. The uses include use as an interleukin-9 inhibitor, as a diagnostic agent for determining interleukin-9, and as a screening agent for pharmaceuticals. The interleukin-9 receptor is characterized as a glycoprotein of about 64 kilodaltons which, upon digestion with N-glycosidase F, yields a peptide of about 54 kilodaltons.
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公开(公告)号：US06375945B1
公开(公告)日：2002-04-23
申请号：US09445841
申请日：2000-02-08
申请人： Thierry Boon , Silvia Silla , Catherine Uyttenhove
发明人： Thierry Boon , Silvia Silla , Catherine Uyttenhove
IPC分类号： A61K3819
CPC分类号： A61K39/39 , A61K2039/55538 , A61K2039/55572 , A61K2039/55577
摘要： The present invention pertains to improved adjuvant compositions comprising a mixture of a saponin adjuvant such as QS21 with monophosphoryl lipid A or derivative thereof such as 3D-MPL and interleukin 12. These compositions are useful in a range of prophylactic and therapeutic applications, particularly in vaccines, including cancer vaccines.
摘要翻译： 本发明涉及包含皂苷佐剂如QS21与单磷酰脂质A或其衍生物如3D-MPL和白细胞介素12的混合物的改进的佐剂组合物。这些组合物可用于一系列预防和治疗应用，特别是在疫苗中 ，包括癌症疫苗。
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