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28 条记录 (耗时 0.028 秒)

    Method of delivering drug with aid of effervescent activity generated in environment of use
    11.
    发明授权
    Method of delivering drug with aid of effervescent activity generated in environment of use 失效
    通过使用环境中产生的泡腾活性来输送药物的方法

    公开(公告)号：US4265874A

    公开(公告)日：1981-05-05

    申请号：US143644

    申请日：1980-04-25

    申请人： Pieter Bonsen ,  Patrick S. Wong ,  Felix Theeuwes

    发明人： Pieter Bonsen ,  Patrick S. Wong ,  Felix Theeuwes

    IPC分类号： B01J4/04 ,  A61K9/00 ,  A61K9/32 ,  A61K9/46 ,  A61J1/00

    CPC分类号： A61K9/0004

    摘要： A method is disclosed for delivering a drug substantially free of rapid precipitation from an osmotic device. The osmotic device comprises a semipermeable wall surrounding a compartment, housing (1) a drug that exhibits limited solubility under neutral and acid conditions; and (2) a compound capable of evolving carbon dioxide in the presence of an acid in the environment of use. The method comprises, (a) imbibing fluid through the wall into the compartment at a rate determined by the permeability of the wall and the osmotic pressure gradient across the wall, (b) forming in the compartment a basic solution containing drug and compound, which solution is delivered from the compartment through the passageway, (c) reacting the compound with the acid in the environment at the device-environment interface for evolving carbon dioxide, thereby, (d) providing an effervescent suspension in the environment that delivers the drug in a finely dispersed form to the environment of use over time. Also, a composition is disclosed comprising the drug and the compound.

    摘要翻译： 公开了用于从渗透装置输送基本上不含快速沉淀的药物的方法。 渗透装置包括围绕隔室的半透壁，壳体（1）在中性和酸性条件下表现出有限溶解度的药物; 和（2）能够在酸性存在下在使用环境中放出二氧化碳的化合物。 该方法包括：（a）将流体通过所述壁吸入所述隔室中，所述速率由所述壁的渗透性和穿过所述壁的渗透压梯度确定，（b）在所述室中形成含有药物和化合物的碱性溶液， 溶液通过通道从隔室输送，（c）使化合物与环境中的酸在设备 - 环境界面反应，用于放出二氧化碳，从而（d）在环境中提供泡腾悬浮液，将环境中的药物递送 随着时间的推移，使用环境的细分散形式。 另外，公开了包含药物和化合物的组合物。

    Device for dispensing microcide formed when device is in environment of use
    14.
    发明授权
    Device for dispensing microcide formed when device is in environment of use 失效
    用于在装置处于使用环境中形成的用于分配微囊的装置

    公开(公告)号：US4144309A

    公开(公告)日：1979-03-13

    申请号：US804961

    申请日：1977-06-09

    申请人： Jimmy B. Langston ,  Harold Leeper ,  Patrick S. Wong

    发明人： Jimmy B. Langston ,  Harold Leeper ,  Patrick S. Wong

    IPC分类号： A61L2/20 ,  A61L9/04

    CPC分类号： A61L2/204

    摘要： A device for dispensing a microcide which consists of a first polymeric material housing a second polymeric material which second material depolymerizes when the device is in the environment of use to form an active microcide. The microcide controls the presence of micro-organisms in the environment over a prolonged period of time.

    摘要翻译： 一种用于分配杀微生物的装置，其由容纳第二聚合物材料的第一聚合物材料组成，当所述装置处于用于形成活性微生物剂的环境中时，所述第二材料解聚。 微生物杀菌剂可以长时间控制环境中微生物的存在。

    Vaginal contraceptive system made from block copolymer
    20.
    发明授权
    Vaginal contraceptive system made from block copolymer 失效
    由嵌段共聚物制成的阴道避孕系统

    公开(公告)号：US4215691A

    公开(公告)日：1980-08-05

    申请号：US950454

    申请日：1978-10-11

    申请人： Patrick S. Wong

    发明人： Patrick S. Wong

    IPC分类号： A61F6/08 ,  A61K9/00 ,  A61F5/46

    CPC分类号： A61F6/08 ,  A61K9/0036

    摘要： An intravaginal contraceptive system for the pre-programmed, unattended delivery of an antifertility steroid is disclosed. The system comprises (a) an antifertility steroid, (b) a delivery module comprising a reservoir for storing the steroid in an amount for execution of the program, a rate controller which maintains the rate of steroid delivered in a contraceptive effective amount throughout the life of the system, an energy source for transferring steroid from the reservoir to the vagina, and a portal for releasing the steroid from the module to the vagina, (c) a platform which integrates the module into a unit sized, shaped and adapted for insertion and retention in a vagina, and (d) a contraceptive program which provides for the controlled release of steroid to produce an antifertility effect over a prolonged period of time.

    摘要翻译： 公开了用于预编程的，无人值守的递送抗生素类固醇的阴道内避孕系统。 该系统包括（a）抗生素类固醇，（b）递送模块，包括用于存储用于执行程序的量的类固醇的储存器;速率控制器，其在整个生命期间保持以避孕有效量递送的类固醇的速率 的系统，用于将类固醇从储存器转移到阴道的能量源，以及用于将所述类固醇从所述模块释放到所述阴道的入口，（c）将所述模块整合成尺寸，形状和适于插入的单元的平台 并保留在阴道内，以及（d）避孕方案，规定控释类固醇在长时间内产生抗生育作用。