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    Nucleic acid sequences using tags
    12.
    发明授权
    Nucleic acid sequences using tags 有权

    公开(公告)号：US10526647B2

    公开(公告)日：2020-01-07

    申请号：US15449757

    申请日：2017-03-03

    申请人： Sergey Kalachikov ,  Jingyue Ju ,  Irina Morozova ,  Michael Dorwart

    发明人： Sergey Kalachikov ,  Jingyue Ju ,  Irina Morozova ,  Michael Dorwart

    IPC分类号： C12Q1/68 ,  C12Q1/6869 ,  G01N27/447 ,  G01N33/487

    摘要： This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.

    NUCLEIC ACID SEQUENCES USING TAGS
    14.
    发明申请
    NUCLEIC ACID SEQUENCES USING TAGS 审中-公开

    公开(公告)号：US20170241948A1

    公开(公告)日：2017-08-24

    申请号：US15449757

    申请日：2017-03-03

    申请人： Sergey Kalachikov ,  Jingyue Ju ,  Irina Morozova ,  Michael Dorwart

    发明人： Sergey Kalachikov ,  Jingyue Ju ,  Irina Morozova ,  Michael Dorwart

    IPC分类号： G01N27/447 ,  G01N33/487 ,  C12Q1/68

    摘要： This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.

    NUCLEIC ACID SEQUENCES USING TAGS
    17.
    发明申请
    NUCLEIC ACID SEQUENCES USING TAGS 审中-公开

    公开(公告)号：US20200248250A1

    公开(公告)日：2020-08-06

    申请号：US16735067

    申请日：2020-01-06

    申请人： Sergey Kalachikov ,  Jingyue Ju ,  Irina Morozova ,  Michael Dorwart

    发明人： Sergey Kalachikov ,  Jingyue Ju ,  Irina Morozova ,  Michael Dorwart

    IPC分类号： C12Q1/6869 ,  G01N33/487 ,  G01N27/447

    摘要： This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides arc provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.

    Gene discovery through comparisons of networks of structural and functional relationships among known genes and proteins
    19.
    发明申请
    Gene discovery through comparisons of networks of structural and functional relationships among known genes and proteins 审中-公开
    通过比较已知基因和蛋白质之间的结构和功能关系网络进行基因发现

    公开(公告)号：US20060069512A1

    公开(公告)日：2006-03-30

    申请号：US10921286

    申请日：2004-08-18

    申请人： Andrey Rzhetsky ,  Sergey Kalachikov ,  Michael Krauthammer ,  Carol Friedman ,  Pauline Kra

    发明人： Andrey Rzhetsky ,  Sergey Kalachikov ,  Michael Krauthammer ,  Carol Friedman ,  Pauline Kra

    IPC分类号： G06F19/00

    CPC分类号： G06Q50/24 ,  G16B5/00 ,  G16B10/00 ,  G16B20/00 ,  G16B30/00 ,  G16B40/00 ,  G16B50/00 ,  Y02A90/22

    摘要： The present invention relates to methods for identifying novel genes comprising: (i) generating one or more specialized databases containing information on gene/protein structure, function and/or regulatory interactions; and (ii) searching the specialized databases for homology or for a particular motif and thereby identifying a putative novel gene of interest. The invention may further comprise performing simulation and hypothesis testing to identify or confirm that the putative gene is a novel gene of interest. The present invention also relates to natural language processing and extraction of relational information associated with genes and proteins that are found in genomics journal articles. To enable access to information in textual form, the natural language processing system of the present invention provides a method for extracting and structuring information found in the literature in a form appropriate for subsequent applications.

    摘要翻译： 本发明涉及用于鉴定新基因的方法，其包括：（i）生成含有关于基因/蛋白质结构，功能和/或调节相互作用信息的一个或多个专门数据库; 和（ii）搜索专门的数据库以获得同源性或特定基序，从而鉴定出推定的新型感兴趣的基因。 本发明还可以包括执行模拟和假设检验以鉴定或确认推定的基因是新的感兴趣的基因。 本发明还涉及在基因组杂志文章中发现的与基因和蛋白质相关的关系信息的自然语言处理和提取。 为了能够以文本形式访问信息，本发明的自然语言处理系统提供了一种用于以适合于后续应用的形式提取和构造文献中发现的信息的方法。