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    Gene discovery through comparisons of networks of structural and functional relationships among known genes and proteins
    1.
    发明申请
    Gene discovery through comparisons of networks of structural and functional relationships among known genes and proteins 审中-公开
    通过比较已知基因和蛋白质之间的结构和功能关系网络进行基因发现

    公开(公告)号：US20060069512A1

    公开(公告)日：2006-03-30

    申请号：US10921286

    申请日：2004-08-18

    申请人： Andrey Rzhetsky ,  Sergey Kalachikov ,  Michael Krauthammer ,  Carol Friedman ,  Pauline Kra

    发明人： Andrey Rzhetsky ,  Sergey Kalachikov ,  Michael Krauthammer ,  Carol Friedman ,  Pauline Kra

    IPC分类号： G06F19/00

    CPC分类号： G06Q50/24 ,  G16B5/00 ,  G16B10/00 ,  G16B20/00 ,  G16B30/00 ,  G16B40/00 ,  G16B50/00 ,  Y02A90/22

    摘要： The present invention relates to methods for identifying novel genes comprising: (i) generating one or more specialized databases containing information on gene/protein structure, function and/or regulatory interactions; and (ii) searching the specialized databases for homology or for a particular motif and thereby identifying a putative novel gene of interest. The invention may further comprise performing simulation and hypothesis testing to identify or confirm that the putative gene is a novel gene of interest. The present invention also relates to natural language processing and extraction of relational information associated with genes and proteins that are found in genomics journal articles. To enable access to information in textual form, the natural language processing system of the present invention provides a method for extracting and structuring information found in the literature in a form appropriate for subsequent applications.

    摘要翻译： 本发明涉及用于鉴定新基因的方法，其包括：（i）生成含有关于基因/蛋白质结构，功能和/或调节相互作用信息的一个或多个专门数据库; 和（ii）搜索专门的数据库以获得同源性或特定基序，从而鉴定出推定的新型感兴趣的基因。 本发明还可以包括执行模拟和假设检验以鉴定或确认推定的基因是新的感兴趣的基因。 本发明还涉及在基因组杂志文章中发现的与基因和蛋白质相关的关系信息的自然语言处理和提取。 为了能够以文本形式访问信息，本发明的自然语言处理系统提供了一种用于以适合于后续应用的形式提取和构造文献中发现的信息的方法。

    Methods and Compositions for Assessing and Treating Cancer
    2.
    发明申请
    Methods and Compositions for Assessing and Treating Cancer 审中-公开
    评估和治疗癌症的方法和组合

    公开(公告)号：US20130315934A1

    公开(公告)日：2013-11-28

    申请号：US13881623

    申请日：2011-10-28

    申请人： Ruth Halaban ,  Michael Krauthammer ,  Joseph Schlessinger ,  Titus J. Boggon

    发明人： Ruth Halaban ,  Michael Krauthammer ,  Joseph Schlessinger ,  Titus J. Boggon

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C07K14/4722 ,  C12N9/14 ,  G01N33/5743 ,  G01N2333/82 ,  G01N2800/52

    摘要： The invention relates to methods and compositions for identifying mutations associated with cancer, such as melanoma. More particularly, the invention relates to methods and compositions for assessing particular mutations as markers for cancer, such as melanoma. Such methods and compositions allow medical providers to diagnose cancer, such as melanoma, based upon the presence of one or more particular mutations in a subject, as compared with an otherwise healthy control. The methods and compositions are also useful in guiding the type of therapy to be applied, and monitoring the effects of the therapy applied.

    摘要翻译： 本发明涉及用于鉴定与癌症相关的突变的方法和组合物，例如黑素瘤。 更具体地，本发明涉及用于评估特定突变作为癌症标志物的方法和组合物，例如黑素瘤。 与其他健康对照相比，这样的方法和组合物允许医疗提供者基于受试者中一种或多种特定突变的存在来诊断癌症，例如黑素瘤。 方法和组合物也可用于指导所应用的治疗类型，并监测所施用的治疗效果。