Assembly for monitoring output characteristics of a modulator
    11.
    发明授权
    Assembly for monitoring output characteristics of a modulator 有权
    用于监视调制器的输出特性的组件

    公开(公告)号:US08891910B2

    公开(公告)日:2014-11-18

    申请号:US13991868

    申请日:2011-12-06

    IPC分类号: G02F1/01 G02F1/225

    摘要: A photonic assembly is described. The assembly comprises a substrate. An optical modulator (100) in or on the substrate has an output port coupled to an output waveguide (106) mounted in or on the substrate. A spiller waveguide (107, 108) is mounted in or on the substrate. The spiller waveguide (107, 108) has an input end (109, 110) physically separated from but proximate to the output waveguide (106) so as to collect light spilt from the output port or output waveguide (106). The modulator (106) may be a MZI modulator.

    摘要翻译: 描述了光子组件。 组件包括基底。 衬底中或衬底上的光学调制器(100)具有耦合到安装在衬底中或衬底上的输出波导(106)的输出端口。 垃圾波导(107,108)安装在基板中或基板上。 垃圾波导(107,108)具有与输出波导(106)物理分离但接近输出波导(106)的输入端(109,110),以便收集从输出端口或输出波导(106)溢出的光。 调制器(106)可以是MZI调制器。

    Purification of air sensitive steroids
    12.
    发明申请
    Purification of air sensitive steroids 审中-公开
    空气敏感类固醇的净化

    公开(公告)号:US20090240049A1

    公开(公告)日:2009-09-24

    申请号:US12383049

    申请日:2009-03-18

    IPC分类号: C07J75/00

    CPC分类号: C07J7/009 C07J43/003

    摘要: The present invention provides a purification method for air sensitive steroids, by reacting an amino acid or an analogue thereof with the 21-aldehyde oxidation product of such air sensitive steroids to form an adduct that is separated from the purified air sensitive steroids.

    摘要翻译: 本发明通过使氨基酸或其类似物与这种空气敏感性类固醇的21-醛氧化产物反应形成与纯化的空气敏感类固醇分离的加合物,提供了一种用于空气敏感性类固醇的纯化方法。

    Process for the preparation of 3-oximino steroids
    14.
    发明申请
    Process for the preparation of 3-oximino steroids 审中-公开
    3-肟基类固醇的制备方法

    公开(公告)号:US20060035872A1

    公开(公告)日:2006-02-16

    申请号:US11202191

    申请日:2005-08-12

    IPC分类号: A61K31/56 C07J41/00

    CPC分类号: C07J41/00 C07J41/0016

    摘要: The present invention provides a method of preparing norelgestromin or norgestimate by reacting the corresponding 3-oxosteroid precursor with hydroxylamine HCl and a base to obtain a reaction mixture forming norelgestromin or norgestimate; monitoring the anti/syn ratio of the norelgestromin or norgestimate produced in the reaction mixture; adding a base to the reaction mixture to neutralize acidity in the reaction mixture when a desired anti/syn ratio is detected; and isolating the norelgestromin or norgestimate. The present invention also provides a process allowing a control of the formation of the anti isomer and syn isomer of norelgestromin or norgestimate by reacting the corresponding 3-oxosteroid precursor with hydroxylamine HCl and a base to obtain a reaction mixture forming norelgestromin or norgestimate; regulating the acidity of the reaction mixture to adjust the anti/syn ratio of the norelgestromin or norgestimate produced in the reaction mixture; adding a base to the reaction mixture to neutralize acidity in the reaction mixture when a desired anti/syn ratio is detected; and isolating the norelgestromin or norgestimate.

    摘要翻译: 本发明提供了通过使相应的3-氧代甾体前体与羟胺HCl和碱反应来制备诺美孕酮或诺孕酯的方法,以获得形成诺美孕酮或诺孕酯的反应混合物; 监测反应混合物中产生的去甲孕酮或诺孕酯的抗/顺应比; 当检测到所需的抗/顺式比时,向反应混合物中加入碱以中和反应混合物中的酸度; 并分离去甲孕酮或诺孕酯。 本发明还提供一种方法,其通过使相应的3-氧代甾体前体与羟胺HCl和碱反应以获得形成去甲孕激素或诺孕酯的反应混合物,从而控制去甲孕酮或诺孕酯的抗异构体和顺式异构体的形成; 调节反应混合物的酸度以调节反应混合物中产生的诺美辛溴或诺孕酯的抗/顺比; 当检测到所需的抗/顺式比时,向反应混合物中加入碱以中和反应混合物中的酸度; 并分离去甲孕酮或诺孕酯。

    Method for manufacture of sertindole
    15.
    发明申请
    Method for manufacture of sertindole 审中-公开
    氯吲哚的制备方法

    公开(公告)号:US20050101788A1

    公开(公告)日:2005-05-12

    申请号:US10509668

    申请日:2003-03-26

    CPC分类号: C07D401/14 C07D209/08

    摘要: The present invention relates to a novel method for manufacture of sertindole comprising manufacturing 5-chloro-1-(4-fluorophenyl)-indole and converting it to sertindole wherein the method for manufacture of 5-chloro-1-(4-fluorophenyl)-indole comprises reacting 5-chloro-indole with a 4-fluorophenylhalide in the presence of a base, a chelating ligand and catalytic amounts of a copper salt comprising copper(I) or copper(II) and an anion which does not interfere in an unfavourable way with the reaction.

    摘要翻译: 本发明涉及一种制造塞丁醇的新方法,其包括制备5-氯-1-(4-氟苯基) - 吲哚并将其转化为三氢吲哚,其中制备5-氯-1-(4-氟苯基) - 吲哚的方法, 吲哚包括在碱,螯合配体和催化量的包含铜(I)或铜(II)的铜盐和不妨碍不利的阴离子的存在下,使5-氯 - 吲哚与4-氟苯基卤反应 方式与反应。