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    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER
    11.
    发明申请
    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER 审中-公开
    生物可降解聚合物载体中的磺胺嘧啶配方

    公开(公告)号：US20090264478A1

    公开(公告)日：2009-10-22

    申请号：US12105375

    申请日：2008-04-18

    申请人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    发明人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    IPC分类号： A61K31/4402 ,  A61P29/00

    CPC分类号： A61K31/635 ,  A61K9/0024 ,  A61K47/34

    摘要： Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长时间的急性疼痛和/或炎症的有效治疗。 通过在目标部位或其附近施用有效量的柳氮磺吡啶可以减轻由不同来源引起的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    LOCALLY ADMINISTRATED LOW DOSES OF CORTICOSTEROIDS
    12.
    发明申请
    LOCALLY ADMINISTRATED LOW DOSES OF CORTICOSTEROIDS 审中-公开
    局部管理低剂量的角质层

    公开(公告)号：US20080317805A1

    公开(公告)日：2008-12-25

    申请号：US11765040

    申请日：2007-06-19

    申请人： William F. McKay ,  John Myers Zanella ,  Christopher M. Hobot

    发明人： William F. McKay ,  John Myers Zanella ,  Christopher M. Hobot

    IPC分类号： A61K31/566 ,  A61K31/56 ,  A61K9/00 ,  A61P25/04

    CPC分类号： A61K31/58 ,  A61K9/0024 ,  A61K31/56 ,  A61K31/566 ,  A61K31/573

    摘要： This invention provides for using a locally delivered low dose of a corticosteroid to treat pain caused by any inflammatory disease including sciatica, herniated disc, stenosis, mylopathy, low back pain, facet pain, osteoarthritis, rheumatoid arthritis, osteolysis, tendonitis, carpal tunnel syndrome, or tarsal tunnel syndrome. More specifically, a locally delivered low dose of a corticosteroid can be released into the epidural space, perineural space, or the foramenal space at or near the site of a patient's pain by a drug pump or a biodegradable drug depot.

    摘要翻译： 本发明提供使用局部递送的低剂量皮质类固醇来治疗由任何炎性疾病引起的疼痛，包括坐骨神经痛，椎间盘突出症，狭窄症，脊髓病，腰背痛，小平面疼痛，骨关节炎，类风湿性关节炎，骨质溶解，腱炎，腕管综合征 ，或t疮综合征。 更具体地，局部递送的低剂量的皮质类固醇可以通过药物泵或可生物降解的药物贮库释放到患者的疼痛部位处或附近的硬膜外腔，神经周围区域或其附近的孔内空间。

    Benzodiazepine formulation in a polyorthoester carrier
    19.
    发明授权
    Benzodiazepine formulation in a polyorthoester carrier 有权
    苯并二氮类制剂在聚原酸酯载体中

    公开(公告)号：US08940315B2

    公开(公告)日：2015-01-27

    申请号：US12426031

    申请日：2009-04-17

    申请人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

    发明人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

    IPC分类号： A61F13/00 ,  A01N43/62 ,  A61K31/55 ,  A61K31/197 ,  A61K9/00 ,  A61K47/34

    CPC分类号： A61K31/197 ,  A61K9/0024 ,  A61K47/34

    摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。