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公开(公告)号：US09144640B2
公开(公告)日：2015-09-29
申请号：US13836973
申请日：2013-03-15
IPC分类号： A61M1/16
CPC分类号： A61M1/1656 , A61M1/1654 , A61M1/1668 , A61M1/167 , A61M1/1696 , A61M1/287 , A61M1/3486 , A61M2205/02 , B01D15/08
摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.
摘要翻译： 一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。 流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合 并且与第一选择的再生物质流体连通地流过第二再生模块。
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公开(公告)号：US08940315B2
公开(公告)日：2015-01-27
申请号：US12426031
申请日：2009-04-17
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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3.发明申请SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION 有权用于改进的透析再生的SORBENT CARTRIDGE配置公开(公告)号：US20140217028A1
公开(公告)日：2014-08-07
申请号：US13836973
申请日：2013-03-15
IPC分类号： A61M1/16
CPC分类号： A61M1/1656 , A61M1/1654 , A61M1/1668 , A61M1/167 , A61M1/1696 , A61M1/287 , A61M1/3486 , A61M2205/02 , B01D15/08
摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.
摘要翻译： 一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。 流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合 并且与第一选择的再生物质流体连通地流过第二再生模块。
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公开(公告)号：US20140217027A1
公开(公告)日：2014-08-07
申请号：US13757709
申请日：2013-02-01
CPC分类号： A61M1/1621 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/165 , A61M1/1652 , A61M1/1656 , A61M1/1658 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1672 , A61M1/1676 , A61M1/169 , A61M1/1696 , A61M1/3413 , A61M1/3437 , A61M1/3609 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/365 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , A61M2205/502 , A61M2205/505 , A61M2209/06 , A61M2230/65
摘要： Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end.
摘要翻译： 用于控制受试者和受控顺应流动路径之间的流体运动和流体体积的系统和方法。 受控制的柔性流动路径具有用于选择性地计量来自受控制的顺应流动路径的流体的计量装置。 体外流路与跨过半透膜的受控顺应性流动路径流体连通，其中体外流路具有第一末端和第二末端。
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公开(公告)号：US20140158588A1
公开(公告)日：2014-06-12
申请号：US13757792
申请日：2013-02-02
IPC分类号： A61M1/16
CPC分类号： A61M1/1696 , A61M1/16 , A61M1/1605 , A61M1/165 , A61M1/287 , A61M1/34 , A61M1/3406 , A61M1/3413 , A61M1/3437 , A61M2205/33 , A61M2205/3324 , A61M2205/50
摘要： Systems and methods for managing the pH of a dialysate fluid during hemodialysis therapy. The systems and methods adjust dialysate pH and buffer concentration to generate a predetermined total bicarbonate buffer concentration in a dialysate entering a dialyzer.
摘要翻译： 用于在血液透析治疗期间管理透析液的pH的系统和方法。 系统和方法调节透析液pH和缓冲液浓度，以在进入透析器的透析液中产生预定的总碳酸氢盐缓冲液浓度。
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6.发明申请公开(公告)号：US20130199998A1
公开(公告)日：2013-08-08
申请号：US13565733
申请日：2012-08-02
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
IPC分类号： A61M1/16
CPC分类号： A61M1/3482 , A61M1/1696 , A61M2202/0021 , A61M2202/0413
摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译： 公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。 用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。 透析电路和用于循环血液的体外循环通过透析膜流体连通。 在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。 该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。
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公开(公告)号：US20120289881A1
公开(公告)日：2012-11-15
申请号：US13462190
申请日：2012-05-02
IPC分类号： A61M1/16
CPC分类号： A61M1/1678 , B01D61/18 , B01D61/28 , B01D63/084 , B01D2313/105
摘要： An implantable dialysis device with a related medical system for intracorporeal dialysis and ultrafiltration of blood, and methods of use are described. The medical system includes an extracorporeal module, a cutaneous module, and an implantable module. Features of the implantable module facilitate delivery and flow of blood and dialysate through the medical system. A filter pack within the implantable module performs dialysis and ultrafiltration of blood. System cleansing is also described.
摘要翻译： 描述了具有用于体内透析和血液超滤的相关医疗系统的植入式透析装置及其使用方法。 医疗系统包括体外模块，皮肤模块和可植入模块。 可植入模块的特征便于血液和透析液通过医疗系统的输送和流动。 可植入模块内的过滤器组件执行血液的透析和超滤。 还描述了系统清洁。
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公开(公告)号：US10857277B2
公开(公告)日：2020-12-08
申请号：US13586824
申请日：2012-08-15
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
摘要： Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.
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公开(公告)号：US08956642B2
公开(公告)日：2015-02-17
申请号：US12426005
申请日：2009-04-17
IPC分类号： A61F2/00 , A01N43/40 , A61K31/445 , A61L31/16
CPC分类号： A61K31/445 , A61K9/0024 , A61K9/0085 , A61K9/1641 , A61K9/1694 , A61K9/5031 , A61L31/16 , A61L2300/402 , A61L2300/602
摘要： Effective treatments of pain, such as chronic pelvic pain, for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of bupivacaine formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供有效的治疗疼痛，如慢性盆腔疼痛，延长时间。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的布比卡因。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。
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公开(公告)号：US20140190876A1
公开(公告)日：2014-07-10
申请号：US13791755
申请日：2013-03-08
CPC分类号： A61M1/1696 , A61M1/284 , A61M1/287 , A61M1/288 , A61M1/3413 , A61M1/3472 , A61M1/3679 , A61M2205/3303 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , B01D15/08 , B01D15/361 , B01J20/0292 , B01J20/048 , B01J20/06 , B01J20/08 , B01J20/20 , B01J20/28052 , B01J39/10 , B01J39/12 , B01J39/18 , B01J41/10 , B01J41/12 , B01J47/012 , B01J47/026 , B01J47/14 , B01J2220/49
摘要： A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid. The system has a sorbent regeneration system for regeneration of the fluid and has a sorbent cartridge that has at least one material layer. The fluid is conveyed through the sorbent cartridge and contacts at least one sensor after having contacted at least one material layer.
摘要翻译： 一种用于测量流体至少一种组分的溶质浓度的基于吸附剂的监测系统。 该系统具有用于再生流体的吸附剂再生系统，并具有至少一个材料层的吸附剂盒。 流体通过吸附剂药筒输送，并且在接触至少一个材料层之后接触至少一个传感器。
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