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公开(公告)号：US08475823B2
公开(公告)日：2013-07-02
申请号：US12426021
申请日：2009-04-17
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of baclofen formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗包括给药一种或多种药物储库，其中药物贮库包括配制在聚原酸酯内的有效量的巴氯芬。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。
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公开(公告)号：US20090202436A1
公开(公告)日：2009-08-13
申请号：US12426005
申请日：2009-04-17
IPC分类号： A61K51/06 , A61L31/16 , A61P29/00 , A61K31/445
CPC分类号： A61K31/445 , A61K9/0024 , A61K9/0085 , A61K9/1641 , A61K9/1694 , A61K9/5031 , A61L31/16 , A61L2300/402 , A61L2300/602
摘要： Effective treatments of pain, such as chronic pelvic pain, for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of bupivacaine formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供有效的治疗疼痛，如慢性盆腔疼痛，延长时间。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的布比卡因。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。
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公开(公告)号：US08956642B2
公开(公告)日：2015-02-17
申请号：US12426005
申请日：2009-04-17
IPC分类号： A61F2/00 , A01N43/40 , A61K31/445 , A61L31/16
CPC分类号： A61K31/445 , A61K9/0024 , A61K9/0085 , A61K9/1641 , A61K9/1694 , A61K9/5031 , A61L31/16 , A61L2300/402 , A61L2300/602
摘要： Effective treatments of pain, such as chronic pelvic pain, for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of bupivacaine formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供有效的治疗疼痛，如慢性盆腔疼痛，延长时间。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的布比卡因。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。
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4.发明授权公开(公告)号：US08323654B2
公开(公告)日：2012-12-04
申请号：US12788116
申请日：2010-05-26
IPC分类号： A61K39/395 , A61K31/70 , A61K31/7028 , A61K31/7032 , C12P21/08 , C07K16/18 , A61M31/00
CPC分类号： C07K16/18 , A61K47/6807 , A61K47/6843 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/24 , C07K2317/515 , C07K2317/56
摘要： Antibody complexes including anti-Aβ antibodies conjugated with a sialic acid-containing molecule show improved bioavailability with no significant adverse effects on binding to amyloid beta.
摘要翻译： 抗体复合物包括抗A＆bgr; 与含唾液酸的分子缀合的抗体显示出改进的生物利用度，对结合淀粉样蛋白β没有显着的不利影响。
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5.发明申请MOISTURE CURABLE MATERIALS FOR DELIVERY OF AGENTS, METHODS, AND MEDICAL DEVICES 审中-公开用于递送药剂，方法和医疗装置的水分可固化材料公开(公告)号：US20100311935A1
公开(公告)日：2010-12-09
申请号：US12846494
申请日：2010-07-29
申请人： Michael E. Benz
发明人： Michael E. Benz
IPC分类号： C08G77/04
CPC分类号： A61L31/16 , A61K47/59 , A61K47/6957 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L2300/00 , A61L2300/80
摘要： The present invention provides curable materials, medical devices incorporating such materials, wherein the curable materials are capable of releasing hydrolyzable leaving agents upon hydrolysis that can form agents (e.g., pharmaceutically active agents), and methods of making and using such materials and devices.
摘要翻译： 本发明提供了可固化材料，包含这种材料的医疗装置，其中可固化材料能够在水解时释放可形成药剂（例如药物活性剂）的水解性离去剂，以及制备和使用这些材料和装置的方法。
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6.发明授权Moisture curable materials for delivery of agents, methods, and medical devices 失效用于递送药剂，方法和医疗器械的湿固化材料公开(公告)号：US07776351B2
公开(公告)日：2010-08-17
申请号：US10842227
申请日：2004-05-10
申请人： Michael E Benz
发明人： Michael E Benz
CPC分类号： A61L31/16 , A61K47/59 , A61K47/6957 , A61L27/18 , A61L27/54 , A61L29/06 , A61L29/16 , A61L31/06 , A61L2300/00 , A61L2300/80
摘要： The present invention provides curable materials, medical devices incorporating such materials, wherein the curable materials are capable of releasing hydrolyzable leaving agents upon hydrolysis that can form agents (e.g., pharmaceutically active agents), and methods of making and using such materials and devices.
摘要翻译： 本发明提供了可固化材料，包含这种材料的医疗装置，其中可固化材料能够在水解时释放可形成药剂（例如药物活性剂）的水解性离去剂，以及制备和使用这些材料和装置的方法。
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7.发明授权公开(公告)号：US06184324B2
公开(公告)日：2001-02-06
申请号：US08993727
申请日：1997-12-18
IPC分类号： C08F1228
CPC分类号： H01G4/18 , Y10T428/31692
摘要： A high energy density capacitor comprising an organic polymeric dielectric material having a dielectric constant of at least about 7; wherein the organic polymeric dielectric material comprises polymerized alkyl (alpha-substituted)acrylate monomers having at least one dipole group; wherein when the monomers are polymerized, the dipole group is attached to the main polymeric chain through a heteroatom-containing linking group.
摘要翻译： 一种高能量密度电容器，包括介电常数为至少约7的有机聚合物介电材料; 其中所述有机聚合物电介质材料包含具有至少一个偶极子基团的聚合的烷基（α-取代的）丙烯酸酯单体; 其中当单体聚合时，偶极基团通过含杂原子的连接基团与主聚合物链连接。
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公开(公告)号：US20090202604A1
公开(公告)日：2009-08-13
申请号：US12426031
申请日：2009-04-17
IPC分类号： A61F13/00 , A61K31/551
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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公开(公告)号：US06879861B2
公开(公告)日：2005-04-12
申请号：US09745619
申请日：2000-12-21
CPC分类号： H01B3/441 , C08K5/5419
摘要： A novel polymeric electrically insulating material that includes a linked voltage stabilizing agent. Also provided are methods of making the novel material and articles and devices that incorporate the novel material, particularly implantable medical devices.
摘要翻译： 一种新型聚合物电绝缘材料，其包括连接的电压稳定剂。 还提供了制造新颖材料和结合新材料的物品和装置的方法，特别是可植入的医疗装置。
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公开(公告)号：US08106146B2
公开(公告)日：2012-01-31
申请号：US12766676
申请日：2010-04-23
申请人： Michael E. Benz , Erica M. Tenbroek , Lian Leon
发明人： Michael E. Benz , Erica M. Tenbroek , Lian Leon
CPC分类号： A61K9/16 , C08G65/002 , C08G65/38
摘要： The invention describes poly(ortho ester) polymers that include at least one therapeutic compound in the polymer backbone. The therapeutic compound includes at least one phenol residue and an aliphatic alcohol residue or two or more phenolic residues.
摘要翻译： 本发明描述了在聚合物主链中包含至少一种治疗化合物的聚（原酸酯）聚合物。 治疗化合物包括至少一种苯酚残基和脂族醇残基或两个或多个酚残基。
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