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公开(公告)号:US08389519B2
公开(公告)日:2013-03-05
申请号:US13471611
申请日:2012-05-15
申请人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
发明人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4709 , A61K31/444 , A61K31/4155 , A61K31/16
CPC分类号: C07D401/12 , C07C233/79 , C07C255/60 , C07C2603/74 , C07D213/81 , C07D215/48 , C07D231/14 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要: The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
摘要翻译: 本发明提供式(I)的金刚烷基 - 二酰胺衍生物:其中R 1和R 2如本文所定义,或其药学上可接受的盐; 以及使用其的药物组合物和方法。
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公开(公告)号:US20110178086A1
公开(公告)日:2011-07-21
申请号:US13075213
申请日:2011-03-30
申请人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
发明人: Hermogenes N. Jimenez , Guiying Li , Dario Doller , Michel Grenon , Andrew D. White , Gil Ma , Maojun Guo
IPC分类号: A61K31/444 , A61K31/4709 , A61K31/5377 , A61P25/00 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/16 , A61P25/24 , A61P25/06 , A61P1/04 , A61P25/32
CPC分类号: C07D401/12 , C07C233/79 , C07C255/60 , C07C2603/74 , C07D213/81 , C07D215/48 , C07D231/14 , C07D239/28 , C07D241/24 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D495/04
摘要: The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and methods using the same.
摘要翻译: 本发明提供式(I)的金刚烷基 - 二酰胺衍生物:其中R 1和R 2如本文所定义,或其药学上可接受的盐; 以及使用其的药物组合物和方法。
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公开(公告)号:US20080174906A1
公开(公告)日:2008-07-24
申请号:US11656659
申请日:2007-01-23
申请人: Alan B. Johnston , Roger L. Hipwell , Bradley J. Ver Meer , John R. Pendray , Steven A. Kalderon , Wayne A. Bonin , Jeffery Kenneth Berkowitz , Hans L. Leuthold , Song Sheng Xue , Nurul Amin , Andrew D. White , Patrick Joseph Ryan
发明人: Alan B. Johnston , Roger L. Hipwell , Bradley J. Ver Meer , John R. Pendray , Steven A. Kalderon , Wayne A. Bonin , Jeffery Kenneth Berkowitz , Hans L. Leuthold , Song Sheng Xue , Nurul Amin , Andrew D. White , Patrick Joseph Ryan
IPC分类号: G11B33/14
CPC分类号: G11B25/043 , G11B19/2009 , G11B33/126
摘要: In general, the invention is directed to techniques for integrated interconnects with a set of disc drives. The interconnects allow for a set of disc drives to be positioned in an array; for example, as set of disc drives may be stacked to communicate with a device through a single interface of the device. The interconnects may be formed as vias within the housing of the disc drives. Vias may produced using MEMS techniques, e.g., electroplating, as part of the manufacturing processes of the disc drive itself.
摘要翻译: 通常,本发明涉及与一组盘驱动器的集成互连的技术。 互连允许将一组盘驱动器定位在阵列中; 例如,作为一组盘驱动器可以被堆叠以通过设备的单个接口与设备通信。 互连可以形成为盘驱动器的壳体内的通孔。 作为盘驱动器本身的制造过程的一部分,可以使用MEMS技术(例如电镀)产生通气孔。
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公开(公告)号:US5185358A
公开(公告)日:1993-02-09
申请号:US719907
申请日:1991-06-24
申请人: Mark W. Creswell , Andrew D. White
发明人: Mark W. Creswell , Andrew D. White
IPC分类号: A61K31/41 , C07D249/12 , C07D249/14 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D285/12 , C07D285/135
CPC分类号: C07D271/07 , A61K31/41 , C07D249/14 , C07D271/113 , C07D285/135
摘要: Compounds useful in treating hypercholesterolemia and atherosclerosis having the formula ##STR1## wherein X is oxygen or sulfur, Het is a monocyclic heterocyclic group having three hetero atoms selected from nitrogen, oxygen and sulfur, and R.sub.1, R.sub.2 and R.sub.3 are hydrogen, flourine, chlorine, bromine, a straight or branched alkyl group having from 1 to 6 carbon atoms, a straight or branched alkoxy group having from 1 to 6 carbon atoms, substituted or unsubstituted benzoyl, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino or substituted amino or a carboxy group.
摘要翻译: 可用于治疗高胆固醇血症和动脉粥样硬化的化合物,其中X是氧或硫,Het是具有三个选自氮,氧和硫的杂原子的单环杂环基,R1,R2和R3是氢,氟,氯 溴,具有1至6个碳原子的直链或支链烷基,具有1至6个碳原子的直链或支链烷氧基,取代或未取代的苯甲酰基,取代或未取代的苯甲酰基,取代或未取代的苯基,氨基或取代的氨基 或羧基。
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公开(公告)号:US5162360A
公开(公告)日:1992-11-10
申请号:US719878
申请日:1991-06-24
申请人: Mark W. Creswell , Andrew D. White
发明人: Mark W. Creswell , Andrew D. White
IPC分类号: C07D277/48
CPC分类号: C07D277/48
摘要: The present invention provides N-substituted aryl-N'-heterocyclic substituted ureas and thioureas of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino, substituted amino, or a monocyclic heterocyclic, or a carboxy group; and Het is a substituted monocyclic heterocyclic group containing two hetero atoms selected from nitrogen, oxygen or sulfur; which are useful in treating hypercholesterolemia and atherosclerosis.
摘要翻译: 本发明提供下式的N-取代的芳基-N'-杂环取代的脲和硫脲,其中R 1,R 2和R 3是氢,氟,氯,溴,烷基,烷氧基,取代或未取代的苯甲酰基,取代或未取代的 苯基,氨基,取代的氨基或单环杂环,或羧基; Het是含有选自氮,氧或硫的两个杂原子的取代的单环杂环基; 其可用于治疗高胆固醇血症和动脉粥样硬化。
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公开(公告)号:US07966890B2
公开(公告)日:2011-06-28
申请号:US12146094
申请日:2008-06-25
申请人: David Louis Dingmann , Eric Thomas Gagner , Troy D. Nickel , Steven R. Seeman , Andrew D. White
发明人: David Louis Dingmann , Eric Thomas Gagner , Troy D. Nickel , Steven R. Seeman , Andrew D. White
CPC分类号: G01N3/32 , G01N2203/0008 , G01N2203/0026 , G01N2203/0208 , G01N2203/0264 , G01N2203/027
摘要: A multi-axis fatigue testing device includes a multi-axis test fixture having a multiple input, multiple output mechanical linkage driven by a plurality of actuators and a controller operating each of the plurality of actuators in real time and in synchronization to produce user-defined multiple fatigue cycle profiles. At least one of the actuators driving the mechanical linkage acts against an artificial load characterized by a stiffness. The stiffness is selected to increase a resonance frequency of the test fixture to allow fatigue testing at higher frequencies for a wider range of samples.
摘要翻译: 多轴疲劳测试装置包括多轴测试夹具,其具有由多个致动器驱动的多输入多输出机械联动器和实时地并且同步地产生用户定义的多个致动器中的每一个的控制器 多个疲劳循环曲线。 驱动机械连杆的致动器中的至少一个作用于以刚度为特征的人造负载。 选择刚度以增加测试夹具的共振频率,以允许在更宽范围的样品的较高频率下的疲劳测试。
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17.
公开(公告)号:US20100280787A1
公开(公告)日:2010-11-04
申请号:US12770868
申请日:2010-04-30
IPC分类号: G06F19/00
CPC分类号: G05B13/025
摘要: Stability of a control system for a materials testing system using specified filter parameters is confirmed by inputting to the control system a test signal having a predetermined waveform, automatically monitoring the output of the materials testing system, and automatically comparing the output to a threshold. If the output exceeds the threshold, a first action is taken. If the output does not exceed the threshold, input of a command signal to the control system is permitted.
摘要翻译: 通过向控制系统输入具有预定波形的测试信号,自动监测材料测试系统的输出以及自动将输出与阈值进行比较来确认用于使用指定滤波器参数的材料测试系统的控制系统的稳定性。 如果输出超过阈值,则采取第一个动作。 如果输出不超过阈值,则允许向控制系统输入命令信号。
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公开(公告)号:US20080174919A1
公开(公告)日:2008-07-24
申请号:US11656919
申请日:2007-01-23
IPC分类号: G11B5/55
CPC分类号: G11B5/4826 , G11B5/4833 , G11B5/5552 , G11B5/5582
摘要: A disc drive head actuator includes a suspension structure and a slider integrated with the suspension structure. The actuator is one of at least two actuator assemblies batch-fabricated on a common substrate. The head actuator may be fabricated using mircofabrication techniques. The head actuator may have a reduced size, including package height relative to conventionally manufactured disc drives. Using mircofabrication and/or batch fabrication techniques provides reduced tolerances, which allows for increased actuation forces and/or reduced power consumption. Some embodiments include four-bar linkage actuators, which increase lateral stiffness of the actuator, allowing for a precise motion of the head relative to a media surface.
摘要翻译: 盘驱动头致动器包括悬架结构和与悬架结构一体的滑块。 致动器是在公共衬底上批量制造的至少两个致动器组件中的一个。 头致动器可以使用微加工技术来制造。 头致动器可以具有减小的尺寸,包括相对于常规制造的盘驱动器的包装高度。 使用微加工和/或批量制造技术提供了减小的公差,其允许增加的致动力和/或降低的功率消耗。 一些实施例包括四杆连杆致动器,其增加致动器的横向刚度,允许头相对于介质表面的精确运动。
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公开(公告)号:US5441975A
公开(公告)日:1995-08-15
申请号:US274088
申请日:1994-07-12
申请人: Helen T. Lee , Patrick M. O'Brien , Joseph A. Picard , Claude F. Purchase, Jr. , Bruce D. Roth , Drago R. Sliskovic , Andrew D. White
发明人: Helen T. Lee , Patrick M. O'Brien , Joseph A. Picard , Claude F. Purchase, Jr. , Bruce D. Roth , Drago R. Sliskovic , Andrew D. White
IPC分类号: A61K31/41 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/435 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/505 , A61P3/06 , A61P9/10 , A61P43/00 , C07D207/337 , C07D215/38 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D249/04 , C07D249/06 , C07D257/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/20 , C07D277/22 , C07D277/30 , C07D285/12 , C07D307/54 , C07D333/24 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D471/04
CPC分类号: C07D231/12 , C07D233/56 , C07D249/04 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/10 , C07D277/22 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04
摘要: Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein n is 0, 1, or 2, for X other than tetrazole and n=2 then R.sub.2 =R.sub.3 =H; R.sub.1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from one to 18 carbon atoms; R.sub.2 and R.sub.3 are hydrogen, halo, hydroxy, alkyl, alkenyl, cycloalkyl, phenyl, substituted phenyl, a heteroaryl, or form a spiroalkyl group; X is a heteromonocyclic 5-membered ring containing one to four heteroatoms, said heteroatoms being nitrogen, oxygen or sulfur, and combination thereof; and R.sub.4 is a hydrocarbon group having from one to 20 carbon atoms are described as well as methods of their manufacture.
摘要翻译: 对于除了四唑之外的X,n = 2,然后R2 = R3 = H,具有式IMAImage的ACAT抑制活性的药学上有用的化合物,其中n为0,1或2。 R 1是苯基,取代的苯基,萘基,取代的萘基,杂芳基或具有1至18个碳原子的烃基; R2和R3是氢,卤素,羟基,烷基,烯基,环烷基,苯基,取代的苯基,杂芳基或形成螺烷基; X是含有一至四个杂原子的杂单环五元环,所述杂原子是氮,氧或硫,以及它们的组合; 并且描述了R4是具有1至20个碳原子的烃基以及它们的制备方法。
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20.
公开(公告)号:US5073565A
公开(公告)日:1991-12-17
申请号:US515984
申请日:1990-04-27
IPC分类号: C07D257/06 , C07D405/12
CPC分类号: C07D405/12 , C07D257/06
摘要: Novel ACAT inhibitors useful in the treatment of atherosclerosis which are N-aryl-N'-tetrazole ureas and thioureas.
摘要翻译: 用于治疗动脉粥样硬化的新型ACAT抑制剂,其为N-芳基-N'-四唑脲和硫脲。
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