公开(公告)号：US10816625B2

公开(公告)日：2020-10-27

申请号：US16095954

申请日：2017-04-26

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Peter Bornert ,  Kay Nehrke ,  Mariya Ivanova Doneva ,  Thomas Erik Amthor ,  Peter Koken ,  George Randall Duensing

IPC: G01R33/50 ,  G01R33/48 ,  G01R33/56 ,  G01R33/561 ,  G01R33/563 ,  G01R33/485

Abstract: The invention provides for a magnetic resonance imaging system (100) for acquiring magnetic resonance data (142) from a subject (118) within an imaging zone (108). The magnetic resonance imaging system comprises a memory (134, 136) for storing machine executable instructions (160), and pulse sequence commands (140, 400, 502, 600, 700), wherein the pulse sequence commands are configured to cause the magnetic imaging resonance system to acquire the magnetic resonance data according to a magnetic resonance fingerprinting technique. The pulse sequence commands are further configured to control the magnetic resonance imaging system to perform spatial encoding using a zero echo time magnetic resonance imaging protocol. Execution of the machine executable instructions causes the processor controlling the MRI system to: acquire (200) the magnetic resonance data by controlling the magnetic resonance imaging system with the pulse sequence commands; and calculate (202) a spatial distribution (146) of each of a set of predetermined substances by comparing the magnetic resonance data with a magnetic resonance fingerprinting dictionary (144).

公开(公告)号：US10591565B2

公开(公告)日：2020-03-17

申请号：US15572182

申请日：2016-04-28

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert

IPC: G01R33/561 ,  G01R33/24 ,  G01R33/56

Abstract: The invention relates to a method of MR imaging of an object (10). The problem of the invention is to provide an improved MR imaging technique that enables fast and robust determination of spatial sensitivity profiles of RF receiving antennas (11, 12, 13) used in parallel imaging as well as B1 and/or B0 mapping. The method of the invention comprises subjecting the object (10) to a stimulated echo sequence. Two or more stimulated echo signals (STE, STE*) are acquired, namely a direct stimulated echo signal (STE) and a conjugated stimulated echo signal (STE*), wherein at least one of the stimulated echo signals (STE, STE*) is received in parallel via an array of two or more RF receiving antennas (11, 12, 13) having different spatial sensitivity profiles, and wherein at least another one of the stimulated echo signals (STE, STE*) is received via a body RF coil (9) having an essentially homogeneous spatial sensitivity profile. Sensitivity maps indicating the spatial sensitivity profiles of the individual RF receiving antennas (11, 12, 13) of the array are derived by comparing the stimulated echo signals (STE, STE*) received via the array of RF receiving antennas (11, 12, 13) with the stimulated echo signals (STE, STE*) received via the body RF coil (9). Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).

公开(公告)号：US10591562B2

公开(公告)日：2020-03-17

申请号：US15735314

申请日：2016-06-07

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Peter Boernert ,  Kay Nehrke ,  Holger Eggers

IPC: G01R33/00 ,  G01R33/48 ,  G01R33/44 ,  G01R33/565 ,  A61B5/055 ,  G01R33/56 ,  A61N5/10

Abstract: The invention provides for a medical instrument (100, 500) comprising a magnetic resonance imaging system (102) for acquiring magnetic resonance data (142) from a subject (118) within an imaging zone (108). The magnetic resonance imaging system comprises: a main magnet (104) for generating a B0 magnetic field within the imaging zone; a memory (134, 136) containing machine executable instructions (160, 162, 164, 166) and pulse sequence commands (140); a processor (130) for controlling the medical instrument. Execution of the machine executable instructions causes the processor to: acquire (200) the magnetic resonance data by controlling the magnetic resonance imaging system with the pulse sequence commands; receive (202) a subject magnetic susceptibility map (144) of the subject; calculate (204) a B0 inhomogeneity map (146) from the magnetic resonance data; calculate (206) a subject B0 magnetic field perturbation (148) from the subject magnetic susceptibility map; calculate (208) a residual B0 magnetic field perturbation (150) by subtracting the subject B0 magnetic field perturbation from the B0 inhomogeneity map; and calculate (210) a bone map (152) from the residual B0 magnetic field perturbation.

公开(公告)号：US20150253406A1

公开(公告)日：2015-09-10

申请号：US14432931

申请日：2013-09-11

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert ,  Johan Michiel Den Harder ,  Thomas Hendrik Rozijn

IPC: G01R33/561 ,  A61B5/055 ,  G01R33/34 ,  G01R33/36 ,  G01R33/385

CPC classification number: G01R33/5611 ,  A61B5/055 ,  G01R33/246 ,  G01R33/34 ,  G01R33/36 ,  G01R33/385

Abstract: The invention relates to a method of parallel MR imaging, wherein a reference scan is performed by means of a stimulated echo sequence including i) at least two preparation RF pulses (a) radiated toward a portion of a body (10) during a preparation period (21), and ii) one or more reading RF pulses 03) radiated toward the portion of the body (10) during an acquisition period (22) temporally subsequent to the preparation period (21). One or more FID signals (I1) and one or more stimulated echo signals (I2) are acquired during the acquisition period (22). The spatial receive and/or—if applicable—transmit4 sensitivity profiles of at least two RF coils (11, 12, 13) are derived from the acquired FID signals (I1) and/or from the acquired stimulated echo signals (I2). The parameters of the stimulated echo sequence are selected such that it is robust against susceptibility-induced artefacts. Moreover, 10 the invention relates to a MR device (1) and to a computer program for a MR device (1).

Abstract translation: 本发明涉及一种并行MR成像的方法，其中通过受激回波序列执行参考扫描，所述回波序列包括i）在准备期间向身体（10）的一部分辐射的至少两个准备RF脉冲（a） （21），以及ii）在所述准备期间（21）之后的采集周期（22）期间朝向所述身体（10）的所述部分辐射的一个或多个读取RF脉冲03）。 在采集周期（22）期间获取一个或多个FID信号（I1）和一个或多个受激回波信号（I2）。 至少两个RF线圈（11,12,13）的空间接收和/或 - 如果可应用的传输4灵敏度分布是从所获取的FID信号（I1）和/或从获取的受激回波信号（I2）导出的。 选择刺激回波序列的参数，使其对抗敏感性诱导的伪像是鲁棒的。 此外，本发明涉及MR装置（1）和用于MR装置（1）的计算机程序。

公开(公告)号：US10156625B2

公开(公告)日：2018-12-18

申请号：US14455165

申请日：2014-08-08

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert

IPC: G01R33/565 ,  G01R33/24 ,  G01R33/561 ,  A61B5/055 ,  A61B5/026

Abstract: A method of MR imaging, wherein a portion of a body placed in the examination volume of a MR device is subjected to an imaging sequence of RF pulses and switched magnetic field gradients. The imaging sequence is a stimulated echo sequence including i) at least two preparation RF pulses (α) radiated toward the portion of the body during a preparation period, and ii) one or more reading RF pulses (β) radiated toward the portion of the body during an acquisition period temporally subsequent to the preparation period. One or more FID signals and one or more stimulated echo signals are acquired during the acquisition period. A B1 map indicating the spatial distribution of the RF field of the RF pulses within the portion of the body is derived from the acquired FID and stimulated echo signals.

公开(公告)号：US10107884B2

公开(公告)日：2018-10-23

申请号：US14774187

申请日：2014-03-12

Applicant: KONINKLIJKE PHILIPS N.V. ,  PHILIPS GMBH

Inventor： Peter Boernert ,  Michel Paul Jurriaan Jurrissen ,  Mariya Ivanova Doneva ,  Adrianus Joseph Willibrordus Duijndam ,  Kay Nehrke

IPC: G01V3/00 ,  G01R33/561 ,  G01R33/34 ,  G01R33/56

Abstract: A parallel magnetic resonance imaging system (1) includes at least one radio frequency (RF) coil (10, 12) with a plurality of coil elements, a smart select unit (24), a parallel imaging parameter unit (28), and a sequence control (16). The smart select unit (24), from a pre-scan or prior scan of a subject with the at least one RF coil, constructs (60) a signal map and a plurality of noise maps based on different sets of reduction factors. The parallel imaging parameter unit (28) selects a set of reduction factors corresponding to a noise map which includes a highest signal-to-noise ratio (SNR). The sequence control (16) performs a magnetic resonance imaging scan of the subject based on the selected reduction factors.

公开(公告)号：US09977106B2

公开(公告)日：2018-05-22

申请号：US14371887

申请日：2013-01-04

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert ,  Ingmar Graesslin ,  Ulrich Katscher ,  Christoph Leussler ,  Holger Eggers

IPC: G01R33/50 ,  G01R33/24 ,  G01R33/54

CPC classification number: G01R33/50 ,  G01R33/243 ,  G01R33/246 ,  G01R33/54

Abstract: In an MR imaging method and apparatus, a portion of a body placed in an examination volume of an MR device is subjected to an imaging sequence of RF pulses and switched magnetic field gradients. The imaging sequence is a stimulated echo sequence including i) two preparation RF pulses (α) radiated toward the portion of the body during a preparation period (21), and ii) reading RF pulses (β) radiated toward the portion of the body during an acquisition period (22) temporally subsequent to the preparation period (21). FID signals (I1) and stimulated echo signals (I2) are acquired during the acquisition period (22) with equal T2*-weighting. A B1 map indicating a spatial distribution of the RF field of the preparation RF pulses within the portion of the body is derived from the acquired FID (I1) and stimulated echo (I2) signals.

公开(公告)号：US20150042335A1

公开(公告)日：2015-02-12

申请号：US14455165

申请日：2014-08-08

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert

IPC: G01R33/565 ,  A61B5/026 ,  A61B5/055 ,  G01R33/24 ,  G01R33/561

CPC classification number: G01R33/5659 ,  A61B5/0263 ,  A61B5/055 ,  G01R33/246 ,  G01R33/5612 ,  G01R33/56509

Abstract: The invention relates to a method of MR imaging, wherein a portion of a body (10) placed in the examination volume of a MR device (1) is subjected to an imaging sequence (IMG) of RF pulses and switched magnetic field gradients. The imaging sequence (IMG) is a stimulated echo sequence including i) at least two preparation RF pulses (α) radiated toward the portion of the body (10) during a preparation period (21), and ii) one or more reading RF pulses (β) radiated toward the portion of the body (10) during an acquisition period (22) temporally subsequent to the preparation period (21). One or more FID signals (I1) and one or more stimulated echo signals (I2) are acquired during the acquisition period (22). A B1 map indicating the spatial distribution of the RF field of the RF pulses within the portion of the body (10) is derived from the acquired FID (I1) and stimulated echo (I2) signals. It is an object of the invention to provide an improved B1 mapping method which can be applied in magnetic resonance angiography (MRA) and, in particular, in cardiac imaging, where the acquisition of a complete B1 map needs to be performed within the diastolic phase of the heartbeat. The invention proposes that the portion of the body (10) is subjected to a suppression sequence (BB) for suppression of MR signals emanating from blood prior to the imaging sequence (IMG). Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).

Abstract translation: 本发明涉及一种MR成像方法，其中放置在MR装置（1）的检查体积中的身体（10）的一部分经受RF脉冲和切换磁场梯度的成像序列（IMG）。 成像序列（IMG）是受激回波序列，包括i）在制备周期（21）期间朝向身体（10）的部分辐射的至少两个准备RF脉冲（α），以及ii）一个或多个读取RF脉冲 （21）中的临时采集期间（22）朝向身体（10）的部分辐射。 在采集周期（22）期间获取一个或多个FID信号（I1）和一个或多个受激回波信号（I2）。 从所获取的FID（I1）和受激回波（I2）信号中导出表示身体（10）部分内的RF脉冲的RF场的空间分布的B1图。 本发明的目的是提供一种改进的B1映射方法，该方法可应用于磁共振血管造影（MRA），特别是在心脏成像中，其中需要在舒张期内进行完整的B1图的获取 的心跳。 本发明提出，身体（10）的部分经受抑制序列（BB），用于抑制在成像序列（IMG）之前从血液发出的MR信号。 此外，本发明涉及MR设备（1）和用于MR设备（1）的计算机程序。

公开(公告)号：US20150002149A1

公开(公告)日：2015-01-01

申请号：US14371887

申请日：2013-01-04

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert ,  Ingmar Graesslin ,  Ulrich Katscher ,  Christoph Leussler ,  Holger Eggers

IPC: G01R33/50 ,  G01R33/54

CPC classification number: G01R33/50 ,  G01R33/243 ,  G01R33/246 ,  G01R33/54

Abstract: The invention relates to a method of MR imaging, wherein a portion of a body placed in the examination volume of an MR device is subjected to an imaging sequence of RF pulses and switched magnetic field gradients. The imaging sequence is a stimulated echo sequence including i) two preparation RF pulses (α) radiated toward the portion of the body during a preparation period (21), and ii) reading RF pulses (β) radiated toward the portion of the body during an acquisition period (22) temporally subsequent to the preparation period (21). FID signals (I1) and stimulated echo signals I2) are acquired during the acquisition period (22) with equal T2*-weighting. A B1 map indicating the spatial distribution of the RF field of the preparation RF pulses within the portion of the body is derived from the acquired FID (I1) and stimulated echo (I2) signals.

Abstract translation: 本发明涉及一种MR成像方法，其中放置在MR装置的检查体积中的身体的一部分经受RF脉冲和切换磁场梯度的成像序列。 成像序列是受刺激的回波序列，包括i）在制备周期（21）期间向身体部分辐射的两个准备RF脉冲（α），以及ii）读取朝向身体部分辐射的RF脉冲（＆bgr） 在准备期间（21）之后的收购期间（22）。 FID信号（I1）和受激回波信号I2）在采集周期（22）期间采用相等的T2 *加权。 从获取的FID（I1）和受激回波（I2）信号中导出指示身体部分内准备RF脉冲的RF场的空间分布的B1图。