公开(公告)号：US20220308148A1

公开(公告)日：2022-09-29

申请号：US17617955

申请日：2020-06-19

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ulrich Katscher ,  Johan Samuel Van Den Brink ,  Jochen Keupp

IPC: G01R33/561 ,  G01R33/56 ,  G01R33/563 ,  A61B5/0536 ,  A61B5/00

Abstract: The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). It is an object of the invention to enable MR signal acquisition in a single scan providing the necessary information for electric properties imaging (EPT), namely a phase map as well as tissue boundaries. The method of the invention comprises the following steps: —subjecting the object (10) to a multi echo steady state imaging sequence or a fast spectroscopic imaging sequence comprising RF pulses and switched magnetic field gradients, wherein two or more echo signals are generated after each RF excitation; —acquiring the echo signals; —deriving a magnitude image and a phase map from the acquired echo signals, which phase map represents the spatial RF field distribution induced by the RF pulses in the object (10); and —reconstructing an electric conductivity map from the magnitude image and from the phase map, wherein tissue boundaries are derived from at least the magnitude image. Moreover, the invention relates to a MR device for carrying out this method as well as to a computer program to be run on a MR device.

公开(公告)号：US09977106B2

公开(公告)日：2018-05-22

申请号：US14371887

申请日：2013-01-04

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert ,  Ingmar Graesslin ,  Ulrich Katscher ,  Christoph Leussler ,  Holger Eggers

IPC: G01R33/50 ,  G01R33/24 ,  G01R33/54

CPC classification number: G01R33/50 ,  G01R33/243 ,  G01R33/246 ,  G01R33/54

Abstract: In an MR imaging method and apparatus, a portion of a body placed in an examination volume of an MR device is subjected to an imaging sequence of RF pulses and switched magnetic field gradients. The imaging sequence is a stimulated echo sequence including i) two preparation RF pulses (α) radiated toward the portion of the body during a preparation period (21), and ii) reading RF pulses (β) radiated toward the portion of the body during an acquisition period (22) temporally subsequent to the preparation period (21). FID signals (I1) and stimulated echo signals (I2) are acquired during the acquisition period (22) with equal T2*-weighting. A B1 map indicating a spatial distribution of the RF field of the preparation RF pulses within the portion of the body is derived from the acquired FID (I1) and stimulated echo (I2) signals.

公开(公告)号：US20150002149A1

公开(公告)日：2015-01-01

申请号：US14371887

申请日：2013-01-04

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Kay Nehrke ,  Peter Boernert ,  Ingmar Graesslin ,  Ulrich Katscher ,  Christoph Leussler ,  Holger Eggers

IPC: G01R33/50 ,  G01R33/54

CPC classification number: G01R33/50 ,  G01R33/243 ,  G01R33/246 ,  G01R33/54

Abstract: The invention relates to a method of MR imaging, wherein a portion of a body placed in the examination volume of an MR device is subjected to an imaging sequence of RF pulses and switched magnetic field gradients. The imaging sequence is a stimulated echo sequence including i) two preparation RF pulses (α) radiated toward the portion of the body during a preparation period (21), and ii) reading RF pulses (β) radiated toward the portion of the body during an acquisition period (22) temporally subsequent to the preparation period (21). FID signals (I1) and stimulated echo signals I2) are acquired during the acquisition period (22) with equal T2*-weighting. A B1 map indicating the spatial distribution of the RF field of the preparation RF pulses within the portion of the body is derived from the acquired FID (I1) and stimulated echo (I2) signals.

Abstract translation: 本发明涉及一种MR成像方法，其中放置在MR装置的检查体积中的身体的一部分经受RF脉冲和切换磁场梯度的成像序列。 成像序列是受刺激的回波序列，包括i）在制备周期（21）期间向身体部分辐射的两个准备RF脉冲（α），以及ii）读取朝向身体部分辐射的RF脉冲（＆bgr） 在准备期间（21）之后的收购期间（22）。 FID信号（I1）和受激回波信号I2）在采集周期（22）期间采用相等的T2 *加权。 从获取的FID（I1）和受激回波（I2）信号中导出指示身体部分内准备RF脉冲的RF场的空间分布的B1图。

公开(公告)号：US12198346B2

公开(公告)日：2025-01-14

申请号：US16959746

申请日：2018-12-28

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Reinhold Wimberger-Friedl ,  Vanda Lucia de Carvalho Vittorino de Almeida ,  Ulrich Katscher

IPC: G06T7/00 ,  A61B5/00 ,  A61B5/055 ,  A61B5/145 ,  A61B6/03 ,  G06N20/00 ,  G06T7/11 ,  G16H15/00 ,  G16H20/40 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50

Abstract: A computerized system for monitoring cancer therapy and a related method. The system comprises an input port (IN) for receiving two or more input images acquired of a subject, the two or more input images capable of recording metabolic activity and extracellular pH level. An evaluator (EVAL) of the system is configured to assess, based on the input images, i) a change over time in metabolic activity and ii) a change over time in extracellular pH level. The evaluator (EVAL) is further configured to establish, based on the assessment, an indication on whether or not there is a response to a cancer therapy in relation to a lesion of the subject or on whether the assessment is inconclusive. The indication is output through an output interface (OUT).

公开(公告)号：US12019134B2

公开(公告)日：2024-06-25

申请号：US17617955

申请日：2020-06-19

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ulrich Katscher ,  Johan Samuel Van Den Brink ,  Jochen Keupp

IPC: G01R33/561 ,  A61B5/00 ,  A61B5/0536 ,  G01R33/56 ,  G01R33/563

CPC classification number: G01R33/5613 ,  A61B5/004 ,  A61B5/0536 ,  G01R33/5607 ,  G01R33/5608 ,  G01R33/5615 ,  G01R33/56341

Abstract: A method of magnet resonance (MR) imaging of an object includes MR signal acquisition in a single scan providing information for electric properties imaging (EPT), which may include a phase map as well as tissue boundaries. The method includes: subjecting the object to a multi echo steady state imaging sequence or a fast spectroscopic imaging sequence that includes RF pulses and switched magnetic field gradients, wherein two or more echo signals are generated after each RF excitation; acquiring the echo signals; deriving a magnitude image and a phase map from the acquired echo signals, which phase map represents the spatial RF field distribution induced by the RF pulses in the object; and reconstructing an electric conductivity map from the magnitude image and from the phase map, wherein tissue boundaries are derived from at least the magnitude image.

公开(公告)号：US10987020B2

公开(公告)日：2021-04-27

申请号：US15772149

申请日：2016-10-17

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Steffen Weiss ,  Ulrich Katscher ,  Christian Stehning ,  Michael Gunter Helle

IPC: A61B5/055 ,  A61B5/107 ,  G01R33/56 ,  G06T7/00 ,  G01R33/48

Abstract: It is an object of the invention to improve tissue classification in MRI images. In particular it is an object of the invention to improve the classification of bone and air in MRI images. This object is achieved by a method for tissue classification in a region of interest in a magnetic resonance (MR) image comprising a first region and a second region, wherein the first region represents air and the second region represents bone. The method comprises the steps of: —acquiring a first magnetic resonance image comprising the first and the second region and; —acquiring a second magnetic resonance image comprising the first and the second region, wherein the first region has a different shape in the second magnetic resonance image compared to the first magnetic resonance image and; —identifying the first region and second region in the first and second image and; —comparing the first image and the second image with respect to the first region and the second region and; —classifying the first region as region representing air based on a presence of a shape difference between the first and the second image and classifying the second region as bone based on an absence of the shape difference between the first and second image.

公开(公告)号：US20200372653A1

公开(公告)日：2020-11-26

申请号：US16959746

申请日：2018-12-28

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Reinhold Wimberger-Friedl ,  Vanda Lucia de Carvalho Vittorino de Almeida ,  Ulrich Katscher

IPC: G06T7/00 ,  G16H50/50 ,  G16H30/40 ,  G16H15/00 ,  G16H50/20 ,  G16H20/40 ,  G06N20/00 ,  G06T7/11 ,  A61B5/00 ,  A61B6/03 ,  A61B5/055

Abstract: A computerized system for monitoring cancer therapy and a related method. The system comprises an input port (IN) for receiving two or more input images acquired of a subject, the two or more input images capable of recording metabolic activity and extracellular pH level. An evaluator (EVAL) of the system is configured to assess, based on the input images, i) a change over time in metabolic activity and ii) a change over time in extracellular pH level. The evaluator (EVAL) is further configured to establish, based on the assessment, an indication on whether or not there is a response to a cancer therapy in relation to a lesion of the subject or on whether the assessment is inconclusive. The indication is output through an output interface (OUT).

公开(公告)号：US10114090B2

公开(公告)日：2018-10-30

申请号：US14434047

申请日：2013-10-01

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ulrich Katscher ,  Hanno Heyke Homann ,  Peter Boernert

IPC: G01V3/00 ,  G01R33/48 ,  G01R33/36 ,  G01R33/483 ,  G01R33/561 ,  G01R33/565 ,  H03F3/19 ,  G01R33/58

Abstract: A magnetic resonance imaging system acquires magnetic resonance data from a target volume in a subject. The magnetic resonance imaging system includes multiple excitation sources for generating a slice-selective or slab-selective spatial radio frequency (RF) excitation magnetic field targeting slice/slab spatial variations in the target volume, and a controller coupled to the excitation sources. The controller is adapted for: determining a power level required by the excitation sources for generating the slice-selective/or slab-selective spatial RF excitation magnetic field, decomposing the slice-selective or slab-selective spatial RF excitation magnetic field into respective RF excitation constituents of the excitation sources, controlling each of the excitation sources to simultaneously generate the respective RF excitation constituent, using the determined power level for acquiring the magnetic resonance data.

公开(公告)号：US20140239951A1

公开(公告)日：2014-08-28

申请号：US14351977

申请日：2012-10-16

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Astrid Lucia Helena Maria Willemina Van Lier ,  Cornelis Antonius Theodorus Van Den Berg ,  Ulrich Katscher

IPC: G01R33/48 ,  G01R33/28

CPC classification number: G01R33/28 ,  A61B5/053 ,  A61B5/055 ,  G01R33/443 ,  G01R33/48

Abstract: The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). It is an object of the invention to enable improved electrical properties tomography. The invention proposes that the method comprises the steps of:—subjecting the object (10) to two or more imaging sequences for acquiring MR signals, wherein the imaging sequences each comprise at least one RF pulse and at least one switched magnetic field gradient; reconstructing two or more MR phase images from MR signals acquired by means of imaging sequences comprising switched magnetic field gradients of opposed polarity; deriving a spatial distribution of electrical properties of the object (10) from the MR phase images.

Abstract translation: 本发明涉及放置在MR装置（1）的检查体积中的物体（10）的MR成像方法。 本发明的目的是能够改进电性能断层摄影。 本发明提出，该方法包括以下步骤： - 将所述物体（10）投射到用于获取MR信号的两个或更多个成像序列，其中所述成像序列各自包括至少一个RF脉冲和至少一个开关磁场梯度; 通过包括相反极性的切换磁场梯度的成像序列获取的MR信号重构两个或更多个MR相位图像; 从MR相位图像导出对象（10）的电特性的空间分布。

公开(公告)号：US11373304B2

公开(公告)日：2022-06-28

申请号：US16962545

申请日：2019-01-17

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Ulrich Katscher ,  Karsten Sommer ,  Axel Saalbach

IPC: G06K9/00 ,  G06T7/00 ,  G16H10/60 ,  G06V20/69

Abstract: The present disclosure relates to a computer implemented medical analysis method for predicting metastases (300) in a test tissue sample, the method comprising: providing a first machine learning model (154) having an input and an output, receiving a description (401) of a tumor (304) and first image data (148) of a test tissue sample of an anatomy region (306), the test tissue sample being free of metastases (300), providing the first image data (148) and the tumor description (401) to the input of the first machine learning model (154), in response to the providing, receiving from the output of the first machine learning model (154) a prediction of occurrence of metastases (300) originating from the tumor (304) in the test tissue sample, and providing the prediction.