公开(公告)号：US11137466B2

公开(公告)日：2021-10-05

申请号：US15535098

申请日：2015-12-11

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Tim Nielsen

IPC分类号： G01R33/561 ,  G01R33/50 ,  A61B5/055 ,  G01R33/565

摘要： MR imaging comprising the steps of: subjecting an object (10) to an imaging sequence of RF pulses and switched magnetic field gradients (GS, GP, GM), which imaging sequence is a steady state sequence comprising a plurality of repeatedly applied acquisition blocks (21), wherein each acquisition block (21) comprises two units (22, 23) in immediate succession, namely: i) a first unit (22) starting with an excitation RF pulse radiated toward the object (10), with the duration of the first unit being an integer multiple of a given time interval T, and ii) a second unit (23) starting with a refocusing RF pulse radiated toward the object (10) and comprising a readout magnetic field gradient (GM) and a phase encoding magnetic field gradient (GP), with the duration of the second unit (23) being an integer multiple of the time interval T, acquiring one or more phase-encoded spin echo signals (31, 32) in a sequence of acquisition blocks (21), and reconstructing one or more MR images from the acquired spin echo signals (31, 32). Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).

公开(公告)号：US11131736B2

公开(公告)日：2021-09-28

申请号：US16323842

申请日：2017-08-03

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Jan Jakob Meineke ,  Ulrich Katscher ,  Tim Nielsen

IPC分类号： G01R33/561 ,  G01R33/24 ,  G01R33/44 ,  G01R33/50 ,  G01R33/56 ,  A61B5/055

摘要： An iterative reconstruction is performed of multiple gradient echo MR imaging data to generate a reconstructed MR image (36). The iterative reconstruction uses a model (30) that links the MR imaging data and the reconstructed MR image. The model includes a parameterized magnetic field fluctuation component (32). During the performing of the iterative reconstruction, parameters of the parameterized magnetic field fluctuation component of the model are updated to optimize a cost function (40) dependent on partial derivatives of the reconstructed MR image with respect to the parameters of the parameterized magnetic field fluctuation component of the model. The image may be further processed to generate an R2* map (50), an SWI image (52), or a QSM map (54).

公开(公告)号：US10955509B2

公开(公告)日：2021-03-23

申请号：US14760845

申请日：2013-12-31

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Michael Gunter Helle ,  Tim Nielsen

IPC分类号： G01V3/00 ,  G01R33/563 ,  G01R33/54 ,  G01R33/385

摘要： A magnetic resonance imaging (MRI) system (100, 600) that generates information indicative of a fluid flow in accordance with a pseudo-continuous arterial spin labeling (pCASL) method. The MRI system may include at least one controller (104, 610) configured to generate a pseudo-continuous arterial spin labeling (pCASL) pulse sequence (200) including at least a first gradient (GR) pulse sequence (207) having a sinusoidal waveform including a plurality of cycles, and a second radio frequency (RF) pulse sequence (205) including a half-wave rectified sinusoidal waveform having a plurality of cycles and which is synchronous with the first GR pulse sequence; label at least part of the fluid flow in a labeling region during a labeling mode using the pCASL pulse sequence; acquire label and control image information of the fluid flow at an imaging region proximal to downstream of the labeling region; and/or generate image information in accordance with a difference of the acquired label and control image information. The sinusoidal gradient waveform results in less acoustic noise during execution of the pulse sequence.

公开(公告)号：US10444315B2

公开(公告)日：2019-10-15

申请号：US14377213

申请日：2013-02-04

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Gabriele Marianne Beck ,  Tim Nielsen ,  Arjan Willem Simonetti ,  Gwenael Henri Herigault ,  Mathijs Visser

IPC分类号： G01R33/565 ,  A61B5/055 ,  G01R33/385 ,  G01R33/34 ,  G01R33/48 ,  G01R33/567

摘要： At least a portion of a body (10) is placed in a main magnetic field Bo within the examination volume of a MR device. The portion of the body (10) is subject to an imaging sequence including one or more RF pulses and switched magnetic field gradients to acquire imaging signals. The portion of the body (10) is subject to a navigator sequence applied at least once before, during, or after the imaging sequence. The navigator sequence includes one or more RF pulses and switched magnetic field gradients controlled to acquire navigator signals with a single-point or multi-point Dixon technique. Translation and/or rotation and/or shear data reflecting motion of the body are derived from the navigator signals during the acquisition of the imaging signals. The translation and/or rotation and/or shear data are used for adapting the imaging sequence and/or for motion correction during reconstruction of an MR image.

公开(公告)号：US10353023B2

公开(公告)日：2019-07-16

申请号：US15102288

申请日：2014-11-27

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Tim Nielsen

IPC分类号： G01R33/24 ,  G01R33/56 ,  G01R33/561

摘要： A magnetic resonance imaging (MRI) system (100) has a radio frequency system (114, 116, 120, 124, 126) for acquiring magnetic resonance data (142, 144, 156). The radio frequency system includes a coil (124) with multiple antenna elements (126). The MRI system further includes a processor (133) for controlling the magnetic resonance imaging system. Execution of instructions (140, 170, 172, 174) cause the processor to: acquire (200) calibration magnetic resonance data (142) from a first field of view within the imaging zone using the multiple antenna elements, calculate (202, 300, 302, 304, 400) modified magnetic resonance data (144) by interpolating the calibration magnetic resonance data to a second field of view, calculate (204, 500, 502, 504, 602) a coil sensitivity kernel (146) by deconvolving the modified magnetic resonance data, and calculate (206, 604, 610) a coil sensitivity (148) by transforming each coil sensitivity kernel into image space. The second field of view encompasses and is larger than the first field of view.

公开(公告)号：US09511244B2

公开(公告)日：2016-12-06

申请号：US14881472

申请日：2015-10-13

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Tim Nielsen ,  Peter Boernert ,  Falk Uhlemann ,  Johannes Adrianus Overweg

IPC分类号： A61B6/00 ,  A61N5/10 ,  G01R33/381 ,  G01R33/48 ,  G01R33/38 ,  G01R33/56

CPC分类号： A61N5/1071 ,  A61N5/1031 ,  A61N5/1039 ,  A61N5/1049 ,  A61N2005/1055 ,  A61N2005/1058 ,  G01R33/3806 ,  G01R33/381 ,  G01R33/4808 ,  G01R33/5601

摘要： A combined magnetic resonance (MR) and radiation therapy system includes a bore-type magnet with a magnet radiation translucent region which allows radiation beams to travel radially through the magnet and a split-type gradient coil includes a gradient coil radiation translucent region aligned to the magnet radiation translucent region. A radiation source, disposed laterally to the magnet, administers a radiation dose through the magnet and gradient coil radiation translucent regions to an examination region. A dosage unit determines the actual radiation dose delivered to each voxel of a target volume and at least one non-target volume based on a pre-treatment, intra-treatment, and/or post-treatment image representation of the target volume and the at least one non-target volume. A planning processor updates at least one remaining radiation dose of a radiation therapy plan based on the determined actual radiation dose.

摘要翻译： 组合磁共振（MR）和放射治疗系统包括具有磁体辐射半透明区域的孔型磁体，其允许辐射束径向穿过磁体，并且分离式梯度线圈包括梯度线圈辐射半透明区域 磁体辐射半透明区域。 辐射源横向设置在磁体上，通过磁体和梯度线圈辐射半透明区域将辐射剂量施加到检查区域。 剂量单位基于目标体积的预处理，治疗前和/或后处理图像表示来确定递送到目标体积的每个体素的实际辐射剂量和至少一个非目标体积， 至少一个非目标卷。 计划处理器基于所确定的实际辐射剂量来更新辐射治疗计划的至少一个剩余辐射剂量。

公开(公告)号：US20150355305A1

公开(公告)日：2015-12-10

申请号：US14760845

申请日：2013-12-31

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Michael Gunter Helle ,  Tim Nielsen

IPC分类号： G01R33/563 ,  G01R33/385 ,  G01R33/54

CPC分类号： G01R33/56366 ,  G01R33/3854 ,  G01R33/543

摘要： A magnetic resonance imaging (MRI) system (100, 600) that generates information indicative of a fluid flow in accordance with a pseudo-continuous arterial spin labeling (pCASL) method. The MRI system may include at least one controller (104, 610) configured to generate a pseudo-continuous arterial spin labeling (pCASL) pulse sequence (200) including at least a first gradient (GR) pulse sequence (207) having a sinusoidal waveform including a plurality of cycles, and a second radio frequency (RF) pulse sequence (205) including a half-wave rectified sinusoidal waveform having a plurality of cycles and which is synchronous with the first GR pulse sequence; label at least part of the fluid flow in a labeling region during a labeling mode using the pCASL pulse sequence; acquire label and control image information of the fluid flow at an imaging region proximal to downstream of the labeling region; and/or generate image information in accordance with a difference of the acquired label and control image information. The sinusoidal gradient waveform results in less acoustic noise during execution of the pulse sequence.

摘要翻译： 根据伪连续动脉自旋标记（pCASL）方法产生指示流体流动的信息的磁共振成像（MRI）系统（100,600）。 MRI系统可以包括被配置为产生伪连续动脉自旋标记（pCASL）脉冲序列（200）的至少一个控制器（104,610），该脉冲序列（200）至少包括具有正弦波形的第一梯度（GR）脉冲序列（207） 包括多个周期，以及第二射频（RF）脉冲序列（205），其包括具有多个周期并与第一GR脉冲序列同步的半波整流正弦波形; 在使用pCASL脉冲序列的标记模式期间在标记区域中标记至少一部分流体流动; 获取标签和控制在标签区域下游的成像区域处的流体流动的图像信息; 和/或根据获取的标签和控制图像信息的差异生成图像信息。 正弦梯度波形在执行脉冲序列期间导致较少的声学噪声。

公开(公告)号：US11959988B2

公开(公告)日：2024-04-16

申请号：US17796685

申请日：2021-02-03

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Tim Nielsen ,  Jan Jakob Meineke

IPC分类号： G01R33/56 ,  G01R33/561

CPC分类号： G01R33/5608 ,  G01R33/5611

摘要： Disclosed herein is a medical system (100, 300). The execution of machine executable instructions (120) causes a processor (104) to: receive (200) measured gradient echo k-space data (122); receive (202) an off-resonance phase map (124); reconstruct (204) an initial image (126) from the measured gradient echo k-space data; calculate (206) an upsampled phase map (128) from the off-resonance phase map; calculate (208) an upsampled image (130) from the initial image; calculating (210) a modulated image (132) by modulating the upsampled image with the upsampled phase map; calculate (212) a corrected image (134) comprising iteratively. The iterative calculation comprises: calculating (214) updated k-space data by applying a data consistency algorithm (138) to a k-space representation of the modulated image and the measured gradient echo k-space data and calculating (216) an updated image (142) from the updated k-space data. Calculation of the updated image comprises demodulation by the upsampled phase map and applying a smoothing algorithm.

公开(公告)号：US11669636B2

公开(公告)日：2023-06-06

申请号：US16814249

申请日：2020-03-10

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Arne Ewald ,  Tim Nielsen ,  Karsten Sommer ,  Irina Waechter-Stehle ,  Christophe Michael Jean Schülke ,  Frank Michael Weber ,  Rolf Jürgen Weese ,  Jochen Peters

IPC分类号： G06F21/62 ,  G16H10/60 ,  G16H30/20 ,  G06N20/00

CPC分类号： G06F21/6254 ,  G06N20/00 ,  G16H10/60 ,  G16H30/20

摘要： A system (100) and computer-implemented method are provided for data collection for distributed machine learning of a machine learnable model. A privacy policy data (050) is provided defining computer-readable criteria for limiting a selection of medical image data (030) to a subset of the medical image data to obfuscate an identity of the at least one patient. The medical image data is selected based on the computer-readable criteria to obtain privacy policy-compliant training data (060) for transmission to another entity. The system and method enable medical data collection at clinical sites without requiring manual oversight, and enables such selections to be made automatically, e.g., based on a request for medical image data which may be received from outside of the clinical site.

公开(公告)号：US11543482B2

公开(公告)日：2023-01-03

申请号：US17285115

申请日：2019-10-14

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Tim Nielsen ,  Jan Hendrik Wuelbern

IPC分类号： G01V3/00 ,  G01R33/565 ,  G01R33/385 ,  G01R33/48 ,  G01R33/56 ,  G01R33/561 ,  G01R33/567

摘要： The invention relates to a method of MR imaging of an object (10). It is an object of the invention to enable MR imaging in the presence of motion of the imaged object, wherein full use is made of the acquired MR signal and a high-quality MR image essentially free from motion artefacts is obtained. The method of the invention comprises the steps of: generating MR signals by subjecting the object (10) to an imaging sequence comprising RF pulses and switched magnetic field gradients; acquiring the MR signals as signal data over a given period of time (T); subdividing the period of time into a number of successive time segments (SO, S1, S2, . . . Sn); deriving a geometric transformation (DVF1, DVF2, . . . DVFn) in image space for each pair of consecutive time segments (S0, S1, S2, . . . Sn), which geometric transformation (DVF1, DVF2, . . . DVFn) reflects motion occurring between the two time segments of the respective pair; and reconstructing an MR image from the signal data, wherein a motion compensation is applied according to the derived geometric transformations (DVF1, DVF2, . . . DVFn). Moreover, the invention relates to an MR device (1) and to a computer program for an MR device (1).