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公开(公告)号：US20250122508A1
公开(公告)日：2025-04-17
申请号：US18982078
申请日：2024-12-16
Inventor： HoWon J. Kim , In-San Kim , Jay S. Kim , Sun Hwa Kim , Ick Chan Kwon , Jong Won Lee , Yoo Soo Yang , Hong Yeol Yoon
IPC: C12N15/113 , A61P35/00
Abstract: Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a cancer cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the cancer cell, the therapeutic compound ultimately being internalized by the target cell via endocytosis.
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12.发明公开公开(公告)号：US20240325550A1
公开(公告)日：2024-10-03
申请号：US18618258
申请日：2024-03-27
Inventor： HoWon J. Kim , In-San Kim , Jay S. Kim , Sun Hwa Kim , Ick Chan Kwon , Jong Won Lee , Yoo Soo Yang , Hong Yeol Yoon
IPC: A61K47/64 , A61P35/00 , C12N15/113
CPC classification number: A61K47/64 , A61P35/00 , C12N15/113 , C12N2310/14 , C12N2310/141
Abstract: Therapeutic compounds for inhibiting and reducing the expression of cell surface proteins and methods for treating cancer, inflammation, and diabetes using the therapeutic compounds.
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公开(公告)号：US20190307794A1
公开(公告)日：2019-10-10
申请号：US16379523
申请日：2019-04-09
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Yeon-Sun HONG , Hyo Suk Kim , Yoo Soo Yang , Sun Hwa Kim , In-San Kim , Ick Chan Kwon
IPC: A61K35/15 , C12N5/0786 , C12N5/0784 , C12N5/0775 , A61K9/127 , C12N5/00
Abstract: The present invention relates to a method of inducing trans-differentiating a first type of immune cell into a second type of immune cell comprising: isolating exosomes from the second type of immune cell that has undergone differentiation, and treating the first type of immune cell or a cell population including the first type of immune cell with the isolated exosomes in vitro.
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