公开(公告)号：US10933033B2

公开(公告)日：2021-03-02

申请号：US16282203

申请日：2019-02-21

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Young Tae Park ,  Taejung Kim ,  Young seok Kim ,  Pilju Choi ,  Kyusun Kim ,  SeonJun Choi ,  BongGeun Song ,  Kisung Kang ,  Buyng Su Hwang ,  Dahae Lee ,  Jihoon Song

IPC: A61K31/122 ,  A61K33/243 ,  A61P13/12 ,  A61K36/062 ,  A61K31/05 ,  A61K31/09

Abstract: A composition for preventing or reducing nephrotoxicity, and use thereof are provided, the composition including a Hypoxylon truncatum extract or an active component thereof.

公开(公告)号：US10004776B2

公开(公告)日：2018-06-26

申请号：US15201819

申请日：2016-07-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Kwantae Kim ,  Pilju Choi ,  Buyng Su Hwang ,  Young Seok Kim

IPC: A61K36/00 ,  A61K36/258 ,  A61K9/00

CPC classification number: A61K36/258 ,  A61K9/00 ,  A61K2236/00

Abstract: Provided are a pharmaceutical composition for preventing or treating skin cancer and a method of preventing or treating skin cancer in a subject by using the pharmaceutical composition, wherein the pharmaceutical composition includes a Panax spp. plant extract as an active ingredient.

公开(公告)号：US11707444B2

公开(公告)日：2023-07-25

申请号：US17465847

申请日：2021-09-03

Applicant: RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jintae Lee ,  Jungyeob Ham ,  Taejung Kim

IPC: A61K31/352 ,  A61K31/192 ,  A61K31/05 ,  A61K31/513 ,  A61K31/4706 ,  A61P31/14 ,  A61K36/185 ,  G01N33/94 ,  G01N33/569 ,  A61K31/675

CPC classification number: A61K31/352 ,  A61K31/05 ,  A61K31/192 ,  A61K31/4706 ,  A61K31/513 ,  A61K31/675 ,  A61K36/185 ,  A61P31/14 ,  G01N33/56983 ,  G01N33/948 ,  G01N2333/165 ,  G01N2500/04

Abstract: The present invention relates to an antiviral composition and a screening method thereof for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that occurred in Wuhan, China in 2019. An extract from leaves or unfertilized female flowers of Cannabis sativa L. or its fraction, and the cannabinoids (CBDs) molecules isolated from it have high binding strength and stability to SARS-CoV-2 MPpro, thereby inhibiting its action as the main protease, to provide a useful lead molecule that can be used alone or in combination with other drugs to treat SARS-CoV-2.

公开(公告)号：US11345667B2

公开(公告)日：2022-05-31

申请号：US16852820

申请日：2020-04-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Taejung Kim ,  Jungyeob Ham ,  Young Tae Park

IPC: C07D235/02

Abstract: The present invention relates to a method of preparing pactalactam represented by Formula 5 below using a total synthesis method: