公开(公告)号：US11717474B2

公开(公告)日：2023-08-08

申请号：US17138312

申请日：2020-12-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Sungdo Ha ,  Seok Lee ,  Jin-Chul Kim ,  Pilju Choi ,  Bong Geun Song

IPC: A61K36/00 ,  A61K8/49 ,  C07D311/80 ,  A23L33/105 ,  A23L5/30

CPC classification number: A61K8/498 ,  A23L5/34 ,  A23L33/105 ,  C07D311/80 ,  A23V2002/00 ,  A61K2236/333 ,  A61K2236/37

Abstract: Provided are: a method of preparing a cannabis processed product having an increased CBN content in an efficient and economic manner, through cyclization of CBD and aromatization of THC by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBN content prepared by the method, a fraction thereof, and a single ingredient of CBN, in foods, drugs, and cosmetics.

公开(公告)号：US11058736B2

公开(公告)日：2021-07-13

申请号：US16549767

申请日：2019-08-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Jin-Chul Kim ,  Chang Geon Kim ,  Bong Geun Song ,  Taejung Kim ,  Pilju Choi ,  Seon-Jun Choi

IPC: A61K36/185 ,  A61P27/04 ,  A61K9/00

Abstract: Provided are a pharmaceutical composition for preventing or treating dry eye syndrome, including an extract of Terminalia chebula or a fraction thereof as an active ingredient, and a method of preventing or treating dry eye syndrome in an individual.

公开(公告)号：US10653732B2

公开(公告)日：2020-05-19

申请号：US15935634

申请日：2018-03-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Bong Chul Chung ,  Taejung Kim ,  Pilju Choi ,  Ki Sung Kang ,  Buyng Su Hwang ,  Kyu Sun Kim

IPC: A61K36/062 ,  A61P3/10 ,  A61K31/122 ,  A23L33/10 ,  A61K31/05 ,  C07C35/44 ,  C07C39/205 ,  C07C39/14

Abstract: Provided are a composition for stimulating insulin secretion from cells, the composition including a Hypoxylon truncatum extract or an active ingredient thereof, and a method of stimulating insulin secretion from cells.

公开(公告)号：US20200061137A1

公开(公告)日：2020-02-27

申请号：US16549767

申请日：2019-08-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Jin-Chul Kim ,  Chang Geon Kim ,  Bong Geun Song ,  Taejung Kim ,  Pilju Choi ,  Seon-Jun Choi

IPC: A61K36/185 ,  A61P27/04

Abstract: Provided are a pharmaceutical composition for preventing or treating dry eye syndrome, including an extract of Terminalia chebula or a fraction thereof as an active ingredient, and a method of preventing or treating dry eye syndrome in an individual.

公开(公告)号：US11649221B2

公开(公告)日：2023-05-16

申请号：US16916920

申请日：2020-06-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Sungdo Ha ,  Seok Lee ,  Deok Ha Woo ,  Pilju Choi ,  Bong Geun Song

IPC: C07D311/80 ,  A61K8/49 ,  A61Q19/00 ,  B01D11/02 ,  A23L33/105

CPC classification number: C07D311/80 ,  A23L33/105 ,  A61K8/498 ,  A61Q19/00 ,  B01D11/0211 ,  B01D11/0288 ,  A23V2002/00 ,  A61K2800/10

Abstract: Provided are a method of preparing a cannabis processed product having an increased Δ9-THC content in an efficient and economic manner, through a cyclization reaction by microwave irradiation of cannabis using various extraction solvents, and use of the processed product having an increased Δ9-THC content prepared by the method, a fraction thereof, and a single ingredient of THC, in foods, drugs, and cosmetics.

公开(公告)号：US11618002B2

公开(公告)日：2023-04-04

申请号：US17221591

申请日：2021-04-02

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Sungdo Ha ,  Seok Lee ,  Young Tae Park ,  Pilju Choi

IPC: B01J19/12

Abstract: A large capacity natural material composition conversion apparatus using a microwave with a preset pressure function includes a chamber including a sealed reaction space accommodating a material, an radiator configured to heat the material by radiating a microwave into the reaction space, a pressure regulator configured to regulate a pressure of the reaction space by supplying a gas into the reaction space, and a controller configured to control the pressure regulator and the radiator, and preliminarily increase a pressure of the reaction space by controlling the pressure regulator before heating the material.

公开(公告)号：US11554149B2

公开(公告)日：2023-01-17

申请号：US17035690

申请日：2020-09-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Seok Lee ,  Bong Geun Song ,  Sungdo Ha ,  Young Tae Park ,  Pilju Choi ,  Hoon Ryu

IPC: A61K36/185 ,  A23L33/105 ,  A61K8/9789 ,  A61K8/34 ,  A61K31/05 ,  B01J19/12

Abstract: Provided are: a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through a decarboxylation reaction by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

公开(公告)号：US11458087B2

公开(公告)日：2022-10-04

申请号：US16893099

申请日：2020-06-04

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Sungdo Ha ,  Bong Chui Chung ,  Seok Lee ,  Pilju Choi ,  Bong Geun Song ,  Deok Ha Woo

IPC: A61K36/00 ,  A61K8/49 ,  A61K31/352 ,  A61K36/73 ,  A61K31/05

Abstract: Provided are a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through decarboxylic acid reaction by microwave irradiation of cannabis using various extraction solvents, and use of the processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

公开(公告)号：US12083490B2

公开(公告)日：2024-09-10

申请号：US17590292

申请日：2022-02-01

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Taejung Kim ,  Jungyeob Ham ,  Young Tae Park ,  Pilju Choi ,  Joonyeon Chang

IPC: B01J19/12 ,  B01J19/24

CPC classification number: B01J19/126 ,  B01J19/243

Abstract: According to an aspect of the disclosure, there is provided a microwave reactor including a container for storing a bath fluid, a tube including an inlet at one end through which a target fluid is introduced, an outlet at another end through which the target fluid is discharged, wherein at least a portion of the tube is submerged in the bath fluid, and at least one radiator located outside the container and configured to irradiate microwaves into the container.

公开(公告)号：US11273192B2

公开(公告)日：2022-03-15

申请号：US16428626

申请日：2019-05-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob Ham ,  Taejung Kim ,  Young Tae Park ,  Kyusun Kim ,  Pilju Choi ,  Seon-Jun Choi ,  Bong Geun Song ,  Jae Young Choi

IPC: A61K36/258 ,  A23L33/105 ,  A61K8/9789 ,  A61K31/704 ,  A61Q19/08 ,  A61K8/63

Abstract: Provided are a method of efficiently producing a ginseng leaf extract including rare ginsenosides Rg6, Rk3, and Rh4 in increased amounts, and use of a ginseng leaf extract produced by the method.