公开(公告)号：US11707444B2

公开(公告)日：2023-07-25

申请号：US17465847

申请日：2021-09-03

申请人： RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Jintae Lee ,  Jungyeob Ham ,  Taejung Kim

IPC分类号： A61K31/352 ,  A61K31/192 ,  A61K31/05 ,  A61K31/513 ,  A61K31/4706 ,  A61P31/14 ,  A61K36/185 ,  G01N33/94 ,  G01N33/569 ,  A61K31/675

CPC分类号： A61K31/352 ,  A61K31/05 ,  A61K31/192 ,  A61K31/4706 ,  A61K31/513 ,  A61K31/675 ,  A61K36/185 ,  A61P31/14 ,  G01N33/56983 ,  G01N33/948 ,  G01N2333/165 ,  G01N2500/04

摘要： The present invention relates to an antiviral composition and a screening method thereof for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that occurred in Wuhan, China in 2019. An extract from leaves or unfertilized female flowers of Cannabis sativa L. or its fraction, and the cannabinoids (CBDs) molecules isolated from it have high binding strength and stability to SARS-CoV-2 MPpro, thereby inhibiting its action as the main protease, to provide a useful lead molecule that can be used alone or in combination with other drugs to treat SARS-CoV-2.

公开(公告)号：US11345667B2

公开(公告)日：2022-05-31

申请号：US16852820

申请日：2020-04-20

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Taejung Kim ,  Jungyeob Ham ,  Young Tae Park

IPC分类号： C07D235/02

摘要： The present invention relates to a method of preparing pactalactam represented by Formula 5 below using a total synthesis method:

公开(公告)号：US09650355B2

公开(公告)日：2017-05-16

申请号：US14760400

申请日：2014-01-28

申请人： Korea Institute of Science and Technology

发明人： Jungyeob Ham ,  Tae Jung Kim ,  Hak Cheol Kwon ,  Kyu Hyuk Jeong ,  Jungho Song ,  Bong Chul Chung

IPC分类号： C07D407/04 ,  C07D409/04 ,  C07D307/88 ,  C07D405/04 ,  C07D493/04

CPC分类号： C07D307/88 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  C07D493/04

摘要： The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

公开(公告)号：US09132160B2

公开(公告)日：2015-09-15

申请号：US13661205

申请日：2012-10-26

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Hyun Ok Yang ,  Hak Cheol Kwon ,  Joon Ki Kim ,  Jin Wook Cha ,  Young-Joo Kim ,  Jungyeob Ham

IPC分类号： A61K36/00 ,  A61K36/489

CPC分类号： A61K36/489 ,  A23L33/105 ,  A23V2002/00 ,  A61K2236/30 ,  A23V2200/334 ,  A23V2250/21

摘要： A method of preventing or alleviating alcohol hangover, which comprises administering one or more selected from the group consisting of Sophora flavescens extracts, dried products of the extracts, and concentrates of the extracts to a subject in need of preventing or alleviating alcohol hangover is provided.

摘要翻译： 提供了一种预防或减轻酒精宿醉的方法，其包括将需要预防或缓解酒精宿醉的受试者中的一种或多种选自由苦参提取物，提取物的干燥产物和提取物的浓缩物组成的组。

公开(公告)号：US11649221B2

公开(公告)日：2023-05-16

申请号：US16916920

申请日：2020-06-30

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Sungdo Ha ,  Seok Lee ,  Deok Ha Woo ,  Pilju Choi ,  Bong Geun Song

IPC分类号： C07D311/80 ,  A61K8/49 ,  A61Q19/00 ,  B01D11/02 ,  A23L33/105

CPC分类号： C07D311/80 ,  A23L33/105 ,  A61K8/498 ,  A61Q19/00 ,  B01D11/0211 ,  B01D11/0288 ,  A23V2002/00 ,  A61K2800/10

摘要： Provided are a method of preparing a cannabis processed product having an increased Δ9-THC content in an efficient and economic manner, through a cyclization reaction by microwave irradiation of cannabis using various extraction solvents, and use of the processed product having an increased Δ9-THC content prepared by the method, a fraction thereof, and a single ingredient of THC, in foods, drugs, and cosmetics.

公开(公告)号：US11618002B2

公开(公告)日：2023-04-04

申请号：US17221591

申请日：2021-04-02

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Sungdo Ha ,  Seok Lee ,  Young Tae Park ,  Pilju Choi

IPC分类号： B01J19/12

摘要： A large capacity natural material composition conversion apparatus using a microwave with a preset pressure function includes a chamber including a sealed reaction space accommodating a material, an radiator configured to heat the material by radiating a microwave into the reaction space, a pressure regulator configured to regulate a pressure of the reaction space by supplying a gas into the reaction space, and a controller configured to control the pressure regulator and the radiator, and preliminarily increase a pressure of the reaction space by controlling the pressure regulator before heating the material.

公开(公告)号：US11554149B2

公开(公告)日：2023-01-17

申请号：US17035690

申请日：2020-09-29

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Jungyeob Ham ,  Taejung Kim ,  Bong Chul Chung ,  Seok Lee ,  Bong Geun Song ,  Sungdo Ha ,  Young Tae Park ,  Pilju Choi ,  Hoon Ryu

IPC分类号： A61K36/185 ,  A23L33/105 ,  A61K8/9789 ,  A61K8/34 ,  A61K31/05 ,  B01J19/12

摘要： Provided are: a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through a decarboxylation reaction by continuous microwave irradiation of a cannabis extract; and use of a processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

公开(公告)号：US11458087B2

公开(公告)日：2022-10-04

申请号：US16893099

申请日：2020-06-04

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Jungyeob Ham ,  Taejung Kim ,  Sungdo Ha ,  Bong Chui Chung ,  Seok Lee ,  Pilju Choi ,  Bong Geun Song ,  Deok Ha Woo

IPC分类号： A61K36/00 ,  A61K8/49 ,  A61K31/352 ,  A61K36/73 ,  A61K31/05

摘要： Provided are a method of preparing a cannabis processed product having an increased CBD content in an efficient and economic manner, through decarboxylic acid reaction by microwave irradiation of cannabis using various extraction solvents, and use of the processed product having an increased CBD content prepared by the method, a fraction thereof, and a single ingredient of CBD, in foods, drugs, and cosmetics.

公开(公告)号：US20140088186A1

公开(公告)日：2014-03-27

申请号：US14036810

申请日：2013-09-25

申请人： The Council for Scientific and Industrial Research ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Hyun Ok Yang ,  Sung-Kwon Chung ,  Hak Cheol Kwon ,  Jin Wook Cha ,  Young-Joo Kim ,  Gerda Fouche ,  Rudzani Nthambeleni ,  Dashnie Naidoo ,  Jeremiah Senabe ,  Vinesh Jaichand Maharaj ,  Eric Khorombi ,  Jungyeob Ham ,  Joon Ki Kim

IPC分类号： A61K31/365 ,  A23L2/52 ,  A23L1/30

CPC分类号： A61K31/365 ,  A23L2/52 ,  A23L33/105 ,  A61K36/185

摘要： A composition for preventing and/or treating dementia and ameliorating memory impairment and/or improving memory, comprising one or more arylnaphthalene lignan derivatives, such as Justicidin A, 5-methoxyjusticidin A, Chinensinaphthol, and a pharmaceutically-acceptable salt thereof, as active ingredient.

摘要翻译： 包含一种或多种芳基萘木酚素衍生物，例如贾斯汀素A，5-甲氧基调节蛋白A，钦嗪萘酚及其药学上可接受的盐作为活性成分的用于预防和/或治疗痴呆并改善记忆障碍和/或改善记忆的组合物 。

公开(公告)号：US12083490B2

公开(公告)日：2024-09-10

申请号：US17590292

申请日：2022-02-01

申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Taejung Kim ,  Jungyeob Ham ,  Young Tae Park ,  Pilju Choi ,  Joonyeon Chang

IPC分类号： B01J19/12 ,  B01J19/24

CPC分类号： B01J19/126 ,  B01J19/243

摘要： According to an aspect of the disclosure, there is provided a microwave reactor including a container for storing a bath fluid, a tube including an inlet at one end through which a target fluid is introduced, an outlet at another end through which the target fluid is discharged, wherein at least a portion of the tube is submerged in the bath fluid, and at least one radiator located outside the container and configured to irradiate microwaves into the container.