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公开(公告)号：USD334896S
公开(公告)日：1993-04-20
申请号：US679406
申请日：1991-04-02
申请人： Norio Shimizu , Hitoshi Ueda
设计人： Norio Shimizu , Hitoshi Ueda
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12.发明授权Apparatus containing a septum which impedes cell permeation for cell culture and method of use 失效含有阻碍细胞培养的细胞渗透的隔膜和使用方法的装置
公开(公告)号：US5151362A
公开(公告)日：1992-09-29
申请号：US505326
申请日：1990-04-05
CPC分类号： C12M29/04 , C12M29/10 , C12M41/00 , Y10S435/813
摘要： By culturing cells in an apparatus containing a first zone in which a cell suspended medium is present and a second zone in which liquid containing a physiological saline solution and/or nutrient sources is present, the first zone being separated from the second zone by a septum with characteristics, such as pores size or electrostatic charges, which impedes the cells from freely permeating through, while allowing at least one of nutrient sources, cell wastes or the product to move between the first zone and the second zone via the septum to proliferate cells in the first zone, wherein a flow rate via the septum is controlled in such a manner that the cell count moved from the first zone into the second zone via the septum does not exceed the cell count increased by cell growth in the first zone. Thus, cell culture at a high cell density can be achieved in a large scale.
摘要翻译： 通过在包含存在细胞悬浮介质的第一区域和存在含有生理盐水溶液和/或营养源的液体的第二区域的装置中培养细胞，第一区域通过隔膜与第二区域分离 具有阻止细胞自由渗透的特征，例如孔径或静电电荷，同时允许营养源，细胞废物或产物中的至少一种通过隔膜在第一区和第二区之间移动以增殖细胞 在第一区域中，其中以通过隔膜从第一区域移动到第二区域的方式控制经由隔膜的流速不超过由第一区域中的细胞生长增加的细胞计数。 因此，可以大规模地实现高细胞密度的细胞培养。
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公开(公告)号：US4991056A
公开(公告)日：1991-02-05
申请号：US413878
申请日：1989-09-28
申请人： Norio Shimizu , Yuichi Watanabe , Hitoshi Manta
发明人： Norio Shimizu , Yuichi Watanabe , Hitoshi Manta
IPC分类号： H05K7/14
CPC分类号： H05K7/1481 , H05K7/1467 , H05K7/1477
摘要： A case is provided for electronic units forming an electronic equipment such as a programmable controller. The case includes a box-type case proper for containing a printed circuit board having connectors to form an electronic circuit, a panel including a terminal board mounting portion and an indicator section for displaying preset values, an indicator section cover for covering a part of the indicator section of the panel, and a cover for covering the upper part of the panel whereby these components are easily combined without using screws or the like. Also, a marking sheet having a color which differs for different types of units can be mounted on the panel. Further, when used as the case for ordinary electronic units, a ground terminal fitting is attached to the back surface of the case proper in manner that the ground terminal fitting is connected to a ground member of a printed circuit board contained in the case proper, and mounting the case on a mother board connects the ground terminal fitting to a ground terminal formed on the mother board.
摘要翻译： 为形成诸如可编程控制器的电子设备的电子单元提供了一种情况。 壳体包括用于容纳具有用于形成电子电路的连接器的印刷电路板的箱型壳体，包括端子板安装部分的面板和用于显示预设值的指示器部分，用于覆盖部分 指示器部分，以及用于覆盖面板的上部的盖，由此这些部件容易地组合而不使用螺钉等。 此外，可以在面板上安装具有不同类型单元的颜色的标记片。 此外，当用作普通电子单元的情况下，将接地端子接头连接到壳体的背面，接地端子接头连接到容纳在壳体中的印刷电路板的接地构件， 并且将壳体安装在母板上将接地端子接头连接到形成在母板上的接地端子。
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公开(公告)号：USD247186S
公开(公告)日：1978-02-07
申请号：US537685
申请日：1974-12-31
申请人： Satoshi Sakai , Norio Shimizu , Junji Nomura
设计人： Satoshi Sakai , Norio Shimizu , Junji Nomura
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15.发明申请APPLICATION OF SYNOVIUM-DERIVED MESENCHYMAL STEM CELLS (MSCS) FOR CARTILAGE OR MENISCUS REGENERATION 审中-公开使用衍生的MESENCHYMAL STEM细胞（MSCS）用于卡培或肉瘤再生公开(公告)号：US20100178274A1
公开(公告)日：2010-07-15
申请号：US12438298
申请日：2007-08-22
CPC分类号： C12N5/0655 , A61K35/12 , C12N5/0668 , C12N2533/54
摘要： An object of the present invention is to provide a method for treating defects of articular cartilage or meniscus of a patient using in vivo chondrogenesis of synovium-derived MSCs. The present invention provides a method for treating a disease associated with defects of cartilage or meniscus. In the present invention, the method for treating a disease associated with defects of cartilage or meniscus comprises the following steps: culturing ex vivo autologous synovium-derived mesenchymal stem cells (MSCs); implanting the MSCs such that said cartilage defect site or meniscal defect site is covered by the MSCs; and regenerating cartilage tissue at the cartilage defect site or meniscal defect site in situ by differentiating the MSCs into cartilage cells.
摘要翻译： 本发明的一个目的是提供一种使用滑膜衍生的MSC的体内软骨形成治疗患者的关节软骨或半月板的缺陷的方法。 本发明提供了治疗与软骨或半月板缺陷有关的疾病的方法。 在本发明中，用于治疗与软骨或半月板缺陷有关的疾病的方法包括以下步骤：培养离体自体滑膜间充质干细胞（MSC）; 植入MSC，使得所述软骨缺损部位或半月板缺损部位被MSC覆盖; 并通过将MSC分化为软骨细胞，在软骨缺损部位或半月板缺损部位原位再生软骨组织。
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16.发明申请Method for treating tumors, infectious diseases, and autoimmune diseases with an activated HLA matching donor-originating lymphocyte 审中-公开用激活的HLA匹配供体来源的淋巴细胞治疗肿瘤，感染性疾病和自身免疫性疾病的方法公开(公告)号：US20080014174A1
公开(公告)日：2008-01-17
申请号：US11834342
申请日：2007-08-06
CPC分类号： C12N5/0636 , A61K2035/124 , C12N2501/23 , C12N2501/515
摘要： According to the present invention, HLA matching donor-originating activated lymphocytes highly effective in the treatment of patients with tumors, viral infections and autoimmune diseases are prepared by collecting cells contained in peripheral blood originating from an HLA matching donor or peripheral blood originating from an HLA matching donor achieving micro-chimerism and by stimulating and propagating the cells thus collected with, for instance, interleukin 2 and anti-CD3 antibodies or the like. The HLA matching donor-originating activated lymphocytes thus prepared can be administered to an HLA matching patient with a tumor, a viral infection or an autoimmune disease for therapeutic or preventive purposes.
摘要翻译： 根据本发明，通过收集源自HLA匹配供体的外周血中含有的细胞，来源于HLA的外周血来源的HLA，可以通过收集高度有效治疗肿瘤，病毒感染和自身免疫疾病患者的HLA匹配供体来源的活化淋巴细胞 匹配供体实现微嵌合体，并通过刺激和繁殖用例如白细胞介素2和抗CD3抗体等收集的细胞。 如此制备的HLA匹配供体来源的活化淋巴细胞可以用于具有肿瘤，病毒感染或自身免疫疾病的HLA匹配患者用于治疗或预防目的。
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公开(公告)号：US20060028115A1
公开(公告)日：2006-02-09
申请号：US11141380
申请日：2005-05-31
申请人： Fumiaki Nihei , Norio Shimizu , Toshio Uchikawa
发明人： Fumiaki Nihei , Norio Shimizu , Toshio Uchikawa
IPC分类号： H01J29/07
CPC分类号： H01J29/07
摘要： The radius of curvature of an outer surface of a panel useful portion is 10,000 mm or more. Assuming that a length of a perforated region of a shadow mask in an X-axis (major axis) direction is 2L, s is a variable satisfying 0
摘要翻译： 面板有用部分的外表面的曲率半径为10,000mm以上。 假设荫罩的X轴（长轴）方向的穿孔区域的长度为2L，s为满足0
= 0.4， = s <= 0.8。 因此，可以提供具有令人满意的可视性的彩色显像管，并且具有由具有优异的可成形性和强度的荫罩引起的拱顶引起的色纯度的降低。-
18.发明授权Cord blood-derived activated lymphocytes, preparations containing said lymphocytes as main ingredient and method and kit for producing said preparations 有权脐带血来源的活化淋巴细胞，含有所述淋巴细胞的制剂作为主要成分，以及用于制备所述制剂的方法和试剂盒公开(公告)号：US06692958B2
公开(公告)日：2004-02-17
申请号：US10003539
申请日：2001-12-04
申请人： Teruaki Sekine , Kiminari Ito , Norio Shimizu , Kenzo Bamba , Tomohiro Yamaguchi , Yasuyuki Kuroiwa
发明人： Teruaki Sekine , Kiminari Ito , Norio Shimizu , Kenzo Bamba , Tomohiro Yamaguchi , Yasuyuki Kuroiwa
IPC分类号： C12N508
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N2501/23 , C12N2501/515
摘要： Activated lymphocytes derived from cord blood are excellently effective for preventing and treating various types of tumors and various types of infection. With interleukin 2 and/or anti-CD3 antibody, the lymphocytes derived from the cord blood is prepared by segregating lymphocytes from the cord blood and proliferating the segregated lymphocytes directly in vitro or segregating monocytes from cord blood and proliferating the monocytes in vitro. Also, the cord blood-derived activated lymphocytes can be effectively used for preventing recurrence of the diseases and promoting the take of stem cells or other organs.
摘要翻译： 来自脐带血的活化淋巴细胞对于预防和治疗各种类型的肿瘤和各种感染是非常有效的。 通过白细胞介素2和/或抗CD3抗体，通过从脐带血分离淋巴细胞并且在体外直接增殖分离的淋巴细胞或从体外将脐带血分离单核细胞并增殖单核细胞来制备来自脐带血的淋巴细胞。 此外，脐带血衍生的活化淋巴细胞可以有效地用于预防疾病的复发和促进干细胞或其他器官的摄入。
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公开(公告)号：US06621206B2
公开(公告)日：2003-09-16
申请号：US09897050
申请日：2001-07-03
申请人： Norio Shimizu , Masatsugu Inoue
发明人： Norio Shimizu , Masatsugu Inoue
IPC分类号： H01J2910
CPC分类号： H01J29/07 , H01J2229/075 , H01J2229/0788
摘要： A panel is provided with a substantially rectangular effective portion that has a substantially flat outer surface, and a phosphor screen is formed on the inner surface of the effective portion. A shadow mask that is opposed to the phosphor screen includes a substantially rectangular mask body formed having a large number of electron beam holes and a mask frame supporting the peripheral edge portion of the mask body. The interval between the electron beam holes in the direction of the major axis of the mask body increases from the center of the mask body toward the major axis end so that the rate of change of the interval has a maximum value in the region between the center of the mask body and the major axis end.
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20.发明授权Color cathode ray tube having particular arrangement of electron beam through hole arrays 失效具有电子束通孔阵列的特定布置的彩色阴极射线管公开(公告)号：US06441545B1
公开(公告)日：2002-08-27
申请号：US09260014
申请日：1999-03-02
IPC分类号： H01J2907
CPC分类号： H01J29/07 , H01J2229/075
摘要： In a color cathode ray tube in which the external surface of an effective portion of a panel has a flat surface or a slight curvature, the shadow mask is set such that the layout distance between electron beam through hole array near the long side of an effective surface of the shadow mask is larger in the vicinity of the short axis than the layout distance at the center of the effective surface. Further, the layout distance becomes gradually smaller in direction away from the short axis, and thereafter, the layout distance changes to an increase. In the vicinity of the short side of the effective surface, the layout distance becomes equal to or larger than the layout distance near the short axis. Therefore, the curvature of the shadow mask and the electron beam through hole array are set in proper condition, and mislanding of beam landing due to deformation or oscillation of the shadow mask can be reduced. At the same time, howling of the phosphor screen can be minimized.
摘要翻译： 在面板的有效部分的外表面具有平坦表面或略微曲率的彩色阴极射线管中，荫罩被设置为使得电子束通孔阵列在长边附近的布局距离有效 荫罩的表面在短轴附近比在有效表面中心的布局距离更大。 此外，布局距离在远离短轴的方向上逐渐变小，此后，布局距离变为增加。 在有效表面的短边附近，布局距离等于或大于短轴附近的布局距离。 因此，阴影掩模和电子束通孔阵列的曲率被设定在适当的条件下，并且可以减小由于荫罩的变形或振动引起的束着色的误着地。 同时，荧光屏的啸声可以最小化。
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