公开(公告)号：US20170056461A1

公开(公告)日：2017-03-02

申请号：US15242762

申请日：2016-08-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Wook LEE ,  Ju Young LEE ,  Jin Soo PARK ,  Jin Wook CHA ,  Hak Cheol KWON ,  Su-Nam KIM ,  Byung Hun UM

IPC: A61K36/28 ,  A23L33/105

CPC classification number: A61K36/28

Abstract: The present disclosure relates to a composition which comprises Centipede minima as an active ingredient. The composition of the present disclosure exhibits an effect of protecting neuronal cells from oxidative stress and inhibiting apoptosis of neuronal cells. In addition, the composition can increase expression of antioxidant enzymes which inhibit cellular apoptosis caused by increased oxidative stress in cells. Accordingly, the composition of the present disclosure can exhibit an effect of preventing, improving or treating secondary diseases that may be caused by apoptosis of neuronal cells due to oxidative stress and can be used as a pharmaceutical or food composition.

Abstract translation: 本公开涉及包含蜈蚣作为活性成分的组合物。 本公开的组合物显示出保护神经元细胞免受氧化应激和抑制神经元细胞凋亡的作用。 此外，该组合物可以增加抑制细胞中氧化应激增加引起的细胞凋亡的抗氧化酶的表达。 因此，本公开的组合物可以表现出预防，改善或治疗由于氧化应激可能由神经元细胞的凋亡引起的继发性疾病的作用，并且可以用作药物或食物组合物。

公开(公告)号：US20150336938A1

公开(公告)日：2015-11-26

申请号：US14760400

申请日：2014-01-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jungyeob HAM ,  Tae Jung KIM ,  Hak Cheol KWON ,  Kyu Hyuk JEONG ,  Jungho SONG ,  Bong Chul CHUNG

IPC: C07D407/04 ,  C07D405/04 ,  C07D493/04 ,  C07D307/88 ,  C07D409/04

CPC classification number: C07D307/88 ,  C07D405/04 ,  C07D407/04 ,  C07D409/04 ,  C07D493/04

Abstract: The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

Abstract translation: 本公开涉及一种制备芳基萘酚化合物的新方法。 在根据本公开的芳基萘木酚素化合物和衍生物的合成中，可以首先构建萘主链，并且可以在最后阶段引入芳基。 通过这种方法，可以有效地合成不能用现有方法准备的各种衍生物。 此外，根据本公开的合成方法适用于大规模生产。

公开(公告)号：US20150133564A1

公开(公告)日：2015-05-14

申请号：US14243488

申请日：2014-04-02

Applicant: SNU R&DB FOUNDATION ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dong-Chan OH ,  Seong-Hwan KIM ,  Jongheon SHIN ,  Hak Cheol KWON ,  So Hee KWON

IPC: C07C49/747 ,  C12P7/26 ,  C12N1/20

CPC classification number: C07C49/747 ,  A61K31/122 ,  C12P7/26 ,  C12R1/465 ,  C12Y114/11 ,  C12Y114/11027

Abstract: Provided are a novel compound, preparing method thereof, and use thereof as inhibitor of histone demethylase. The compound represented by Chemical Formula 1 has activity which inhibits histone demethylase and thus is capable of specifically and effectively inhibit activity of histone demethylase.

Abstract translation: 提供一种新型化合物，其制备方法及其作为组蛋白脱甲基酶抑制剂的用途。 由化学式1表示的化合物具有抑制组蛋白脱甲基酶的活性，因此能够特异性且有效地抑制组蛋白脱甲基酶的活性。