公开(公告)号：US20200342957A1

公开(公告)日：2020-10-29

申请号：US16857765

申请日：2020-04-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Keunwan PARK ,  Cheol-Ho PAN ,  Young-Joon KO ,  Prasannavenkatesh DURAI ,  Yongsoo CHOI ,  Moon-Hyeong SEO ,  Kyungsu KANG ,  Jin Soo PARK ,  Jaeyoung KWON

IPC: G16B20/30 ,  G16B40/20 ,  G16B15/30

Abstract: The present invention relates to an ensemble evolutionary chemical binding similarity (ensECBS) model, which is a chemical binding similarity searching method widely applicable as a powerful tool for representing an unknown relationship between chemicals by using evolutionary information of proteins binding to chemicals.

公开(公告)号：US20250099390A1

公开(公告)日：2025-03-27

申请号：US18730898

申请日：2023-01-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ki Young CHOI ,  Kwang-Hyun CHA ,  Hwa Seung HAN ,  Jin Soo PARK ,  Dae-geun SONG ,  Myung Suk KIM ,  Hak Cheol KWON

IPC: A61K9/50 ,  A61K35/74 ,  A61K35/745 ,  A61P37/06

Abstract: Provided is a method for preventing, ameliorating, or treating inflammatory diseases by administering a composition containing extracellular vesicles (EVs) derived from Roseburia spp. strains and/or Bifidobacterium spp. strains, wherein the EVs exhibits effectiveness in improving inflammatory bowel disease (IBD), and additionally, all EVs derived from congeneric strains corresponding to Roseburia spp. strains or Bifidobacterium spp. strains. have been confirmed to exhibit strong anti-inflammatory effect, and the strains and EVs derived therefrom can be provided as a composition for preventing, ameliorating, or treating a variety of inflammatory diseases.

公开(公告)号：US20210393723A1

公开(公告)日：2021-12-23

申请号：US17354380

申请日：2021-06-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyungsu KANG ,  Jae Young KWON ,  Hak Cheol KWON ,  Jin Chul KIM ,  Jin Soo PARK ,  Ho Seong HWANG ,  Seemi Tasnim ALAM

IPC: A61K36/28 ,  A61K41/00 ,  A61P31/04 ,  A61P31/10 ,  A01N65/12 ,  A61L2/00 ,  A61L2/26 ,  A61L2/08 ,  A61L2/10 ,  A23L3/3472 ,  A23L3/28 ,  A23B4/20 ,  A23B4/015 ,  A23B7/154 ,  A23B7/015 ,  C02F1/32 ,  C02F1/50

Abstract: Provided are methods of reducing and killing bacteria and fungi, and photodynamic treatment methods and sterilization methods using the methods of reducing and killing bacteria and fungi. The method of reducing and killing bacteria and fungi includes bringing a composition including a Ligularia fischeri extract or a fraction thereof as an active ingredient into contact with cells or tissues of a subject and irradiating cells or tissues of a subject in contact with the composition with an absorbable wavelength of excitation light.

公开(公告)号：US20210240076A1

公开(公告)日：2021-08-05

申请号：US16923965

申请日：2020-07-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： MaeSoon IM ,  Byung Chul LEE ,  Young Jun YOON ,  Jin Soo PARK ,  Seung Min KWAK

IPC: G03F7/004 ,  A61B5/04 ,  A61N1/05

Abstract: Disclosed are a method for manufacturing a high-density neural probe including needles having various forms and a neural probe manufactured thereby. The method, in which only a photolithography process and an etching process are used, simplifies a manufacturing process of the neural probe, minimizes changes in the characteristics of the neural probe depending on process equipment or conditions, and may thus ensure a high yield, thereby being advantageous in terms of commercialization. In addition, various forms of needles may be manufactured depending on the shape of patterns included in a mask, the height of the needles may be controlled by adjusting the size of the patterns and the gap between the patterns, and thereby, a neural probe having a plurality of needles having different heights may be manufactured.

公开(公告)号：US20190381122A1

公开(公告)日：2019-12-19

申请号：US16555950

申请日：2019-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chu Won NHO ,  Hak Cheol KWON ,  Ji-Hye YOO ,  Jaeyoung KWON ,  Jin Soo PARK ,  Hyuk-Jai JANG ,  Seong-Su KIM ,  Cheon Soo PARK ,  Hwa-Mi LEE ,  Hee Ju LEE

IPC: A61K36/28 ,  A23L33/00 ,  A23L33/105

Abstract: Provided are a pharmaceutical composition including a Crepidiastrum denticulatum extract as an active ingredient; and a method for preventing or treating ischemia-reperfusion injury in a subject by using a food composition or the pharmaceutical composition.

公开(公告)号：US20220234301A1

公开(公告)日：2022-07-28

申请号：US17412265

申请日：2021-08-26

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Byung Chul LEE ,  Dong-Hyun KANG ,  Shinyong SHIM ,  Dong Jun KIM ,  Jin Soo PARK ,  Ki Joo PAHK ,  Hyejeong SEONG

IPC: B29C65/16 ,  B29C65/00 ,  B23K26/362 ,  B05B17/00 ,  B05B1/26

Abstract: A mesh type atomizer according to an embodiment includes a porous thin film having a multi-hole structure, a metal layer covering a remaining area except a nozzle area in which droplets are sprayed through the holes on a surface of the porous thin film, and an ultrasonic transducer to output ultrasonic waves to vibrate the porous thin film. According to an embodiment, it is possible to atomize a liquid into nanometer-level fine particles using the porous thin film including nanometer sized holes. It is possible to precisely adjust the sprayed droplet size by setting the shape, size and cycle of the nozzle in the manufacturing process, and it is possible to selectively increase the strength of the mesh by growing the metal material in the hole of the porous thin film through electroplating.

公开(公告)号：US20180085414A1

公开(公告)日：2018-03-29

申请号：US15717337

申请日：2017-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chu Won NHO ,  Hak Cheol KWON ,  Ji-Hye YOO ,  Jaeyoung KWON ,  Jin Soo PARK ,  Hyuk-Jai JANG ,  Seong-Su KIM ,  Cheon Soo PARK ,  Hwa-Mi LEE ,  Hee Ju LEE

IPC: A61K36/28 ,  A23L33/105 ,  A23L33/00

CPC classification number: A61K36/28 ,  A23L33/105 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61P9/10

Abstract: Provided are a pharmaceutical composition including a Crepidiastrum denticulatum extract as an active ingredient; and a method for preventing or treating ischemia-reperfusion injury in a subject by using a food composition or the pharmaceutical composition.

公开(公告)号：US20170056461A1

公开(公告)日：2017-03-02

申请号：US15242762

申请日：2016-08-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jae Wook LEE ,  Ju Young LEE ,  Jin Soo PARK ,  Jin Wook CHA ,  Hak Cheol KWON ,  Su-Nam KIM ,  Byung Hun UM

IPC: A61K36/28 ,  A23L33/105

CPC classification number: A61K36/28

Abstract: The present disclosure relates to a composition which comprises Centipede minima as an active ingredient. The composition of the present disclosure exhibits an effect of protecting neuronal cells from oxidative stress and inhibiting apoptosis of neuronal cells. In addition, the composition can increase expression of antioxidant enzymes which inhibit cellular apoptosis caused by increased oxidative stress in cells. Accordingly, the composition of the present disclosure can exhibit an effect of preventing, improving or treating secondary diseases that may be caused by apoptosis of neuronal cells due to oxidative stress and can be used as a pharmaceutical or food composition.

Abstract translation: 本公开涉及包含蜈蚣作为活性成分的组合物。 本公开的组合物显示出保护神经元细胞免受氧化应激和抑制神经元细胞凋亡的作用。 此外，该组合物可以增加抑制细胞中氧化应激增加引起的细胞凋亡的抗氧化酶的表达。 因此，本公开的组合物可以表现出预防，改善或治疗由于氧化应激可能由神经元细胞的凋亡引起的继发性疾病的作用，并且可以用作药物或食物组合物。