公开(公告)号：US07157269B2

公开(公告)日：2007-01-02

申请号：US10670225

申请日：2003-09-26

申请人： Bor-Iaun Jan ,  Jia-Huey Tsao ,  Chih-Wei Ho ,  Yu-Ching Liu ,  Chao-Chi Pan ,  Zu-Sho Chow ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Wen-Hsun Kuo

发明人： Bor-Iaun Jan ,  Jia-Huey Tsao ,  Chih-Wei Ho ,  Yu-Ching Liu ,  Chao-Chi Pan ,  Zu-Sho Chow ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Wen-Hsun Kuo

IPC分类号： C12M3/00 ,  G01N33/566 ,  G01N33/00 ,  C07H21/04 ,  B01L3/00

CPC分类号： B82Y30/00 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00677 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/545 ,  G02B21/34 ,  Y10T436/143333

摘要： The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.

摘要翻译： 本发明公开了一种现场亲水增强载玻片/微阵列。 该制备方法涉及通过共混，接枝或共聚疏水材料和带有官能团的化合物如酸酐，酰亚胺，环状酰胺和环状酯制备的疏水性共聚物，以及将疏水性共聚物应用于有机或 无机底物。 所得到的载片具有现场亲水/疏水动态转化的性质，以及用于制备高密度和高效率生物芯片/微阵列的现场亲水增强。

公开(公告)号：US06960468B2

公开(公告)日：2005-11-01

申请号：US10136357

申请日：2002-05-02

申请人： Bor-Iuan Jan ,  Jia-Huey Tsao ,  Chih-Wei Ho ,  Yu-Ching Liu ,  Chao-Chi Pan ,  Zu-Sho Chow ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Wen-Hsun Kuo

发明人： Bor-Iuan Jan ,  Jia-Huey Tsao ,  Chih-Wei Ho ,  Yu-Ching Liu ,  Chao-Chi Pan ,  Zu-Sho Chow ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Wen-Hsun Kuo

IPC分类号： C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/545 ,  G02B21/34 ,  C12M1/34 ,  C07H21/02 ,  G01N33/53

CPC分类号： B82Y30/00 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00677 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/545 ,  G02B21/34 ,  Y10T436/143333

摘要： The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.

摘要翻译： 本发明公开了一种现场亲水增强载玻片/微阵列。 该制备方法涉及通过共混，接枝或共聚疏水材料和带有官能团的化合物如酸酐，酰亚胺，环状酰胺和环状酯制备的疏水性共聚物，以及将疏水性共聚物应用于有机或 无机底物。 所得到的载片具有现场亲水/疏水动态转化的性质，以及用于制备高密度和高效率生物芯片/微阵列的现场亲水增强。

公开(公告)号：US06528291B1

公开(公告)日：2003-03-04

申请号：US09658945

申请日：2000-09-11

申请人： Zu-Sho Chow ,  Jia-Huey Tsao ,  Wen-Hsun Kuo ,  Chih-Wei Ho ,  Bor-Iuan Jan ,  Chao-Chi Pan ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Yu-Ching Liu

发明人： Zu-Sho Chow ,  Jia-Huey Tsao ,  Wen-Hsun Kuo ,  Chih-Wei Ho ,  Bor-Iuan Jan ,  Chao-Chi Pan ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Yu-Ching Liu

IPC分类号： C12N1114

CPC分类号： B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00576 ,  B01J2219/00677 ,  G01N33/54353 ,  G01N33/545 ,  G01N33/551 ,  G01N33/552 ,  Y10S530/811 ,  Y10S530/815 ,  Y10S530/816

摘要： A method is provided for preparing an active slide, including introducing a monomer containing an aldehyde group, or a mixture of a monomer containing an aldehyde group and an acidic functional group provider into a plasma chamber; and depositing the aldehyde group and acidic functional group onto the surface of an organic or inorganic matrix using plasma deposition to form a slide comprising a layer of polymerized actively functional groups thereon. The aldehyde groups and negatively charged groups are deposited on the surface of the active slide, such that the bio-molecules bound thereto possess the properties of an inducible orientation and thus form a mono-layer.

摘要翻译： 提供了制备活性载体的方法，包括将含有醛基的单体或含有醛基的单体和酸性官能团提供剂的混合物引入等离子体室中; 以及使用等离子体沉积法将醛基和酸性官能团沉积在有机或无机基体的表面上以形成包含其上聚合的主动官能团层的载玻片。 醛基和带负电荷的基团沉积在活性载体的表面上，使得与其结合的生物分子具有可诱导取向的特性，从而形成单层。

公开(公告)号：US06403368B1

公开(公告)日：2002-06-11

申请号：US09695254

申请日：2000-10-25

申请人： Bor-Iuan Jan ,  Jia-Huey Tsao ,  Chih-Wei Ho ,  Chao-Chi Pan ,  Zu-Sho Chow ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Wen-Hsun Kuo

发明人： Bor-Iuan Jan ,  Jia-Huey Tsao ,  Chih-Wei Ho ,  Chao-Chi Pan ,  Zu-Sho Chow ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Wen-Hsun Kuo

IPC分类号： C12M134

CPC分类号： B82Y30/00 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00677 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00729 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N33/545 ,  G02B21/34 ,  Y10T436/143333

摘要： The invention discloses an on-spot hydrophilic enhanced slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing functional groups such as anhydride, imide, cyclic amide, and cyclic ester, and application of the hydrophobic copolymer onto an organic or inorganic substrate. The resulting slide has the properties of on-spot hydrophilic/hydrophobic dynamic conversion, as well as on-spot hydrophilic enhancement for the preparation of high-density and high-efficiency bio-chip/microarray.

摘要翻译： 本发明公开了一种现场亲水增强载玻片/微阵列。 该制备方法涉及通过共混，接枝或共聚疏水材料和带有官能团的化合物如酸酐，酰亚胺，环状酰胺和环状酯制备的疏水性共聚物，以及将疏水性共聚物应用于有机或 无机底物。 所得到的载片具有现场亲水/疏水动态转化的性质，以及用于制备高密度和高效率生物芯片/微阵列的现场亲水增强。

公开(公告)号：US06733894B2

公开(公告)日：2004-05-11

申请号：US10246402

申请日：2002-09-19

申请人： Chih-Wei Ho ,  Zu-Sho Chow ,  Bor-Iuan Jan ,  Jia-Huey Tsao ,  Chao-Chi Pan ,  Wen-Hsun Kuo ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Yu-Ching Liu

发明人： Chih-Wei Ho ,  Zu-Sho Chow ,  Bor-Iuan Jan ,  Jia-Huey Tsao ,  Chao-Chi Pan ,  Wen-Hsun Kuo ,  Yao-Sung Chang ,  Cheng-Tao Wu ,  Yu-Ching Liu

IPC分类号： B32B2742

CPC分类号： B82Y30/00 ,  B01J19/0046 ,  B01J2219/00387 ,  B01J2219/00529 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00677 ,  C07B2200/11 ,  C40B60/14 ,  Y10T428/31612 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31786 ,  Y10T428/31938 ,  Y10T428/31942

摘要： The invention features a method for preparing a high-density functional slide by coating a sol-gel containing amine-group bearing silanes and a solution containing polyaldehyde groups onto an organic or inorganic substrate, respectively. The resulting slide is useful in the preparation of highly homogeneous functional-group slides and the high-density and high-efficiency bio-chip/microarray.

摘要翻译： 本发明的特征在于通过将含有胺基的硅烷和含有多醛基团的溶液分别涂布到有机或无机基材上来制备高密度功能性载体的方法。 所得到的载片可用于制备高度均匀的功能团载片和高密度和高效率的生物芯片/微阵列。