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公开(公告)号：US20110213001A1
公开(公告)日：2011-09-01
申请号：US13000442
申请日：2009-06-25
IPC分类号： A61K31/4422 , C07D221/00 , A61P35/00 , A61P19/02 , A61P29/00 , A61P25/16
CPC分类号： C07D211/88 , A61K31/45
摘要： The object of the present invention is to provide a pharmaceutical composition that inhibits expression of iNOS and COX-2 without inhibiting NF-κB. The pharmaceutical composition that inhibits expression of iNOS and COX-2 without inhibiting NF-κB contains DTCM glutarimide of the Formula (I) as an effective ingredient, thereby being able to inhibit nitric oxide (NO) production and prostaglandin production.
摘要翻译： 本发明的目的是提供抑制iNOS和COX-2的表达而不抑制NF-κB的药物组合物。 抑制iNOS和COX-2表达而不抑制NF-κB的药物组合物含有式（I）的DTCM戊二酰亚胺作为有效成分，从而能够抑制一氧化氮（NO）的产生和前列腺素的产生。
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公开(公告)号：US06758428B1
公开(公告)日：2004-07-06
申请号：US10009899
申请日：2001-12-14
申请人： Kazuo Hiraguchi , Hiroyuki Naito , Katsuki Asano , Shigeru Nishiyama , Hideki Uchikura , Akihiro Hashimoto
发明人： Kazuo Hiraguchi , Hiroyuki Naito , Katsuki Asano , Shigeru Nishiyama , Hideki Uchikura , Akihiro Hashimoto
IPC分类号： G11B23087
CPC分类号： G11B23/037 , G11B15/66 , G11B23/08728
摘要： A receiving surface (625) for use in the supersonic welding of the welding boss (620) of an M cassette tape reel (612a) is composed of the lower surface of a ring portion (626) which is formed so as to extend annularly along the base end of a hub central portion (621) formed in the bottom surface (616a) of a lower reel (616) and also which is projected downward (in FIG. 2) by a given amount from the bottom surface (616a). That is, the receiving surface (625) is situated slightly outside in the radial direction from directly below the welding boss (620).
摘要翻译： 用于M盒式磁带卷盘（612a）的焊接凸台（620）的超音速焊接的接收表面（625）由环形部分（626）的下表面构成，环形部分（626）的下表面形成为沿着 形成在下卷轴（616）的底面（616a）中并且从底面（616a）向下（图2）向下突出一定量的轮毂中心部分（621）的基端。 也就是说，接收表面（625）从焊接凸台（620）的正下方沿径向方向略微偏离外侧。
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公开(公告)号：USD428050S
公开(公告)日：2000-07-11
申请号：US105995
申请日：1999-06-01
申请人： Shigeru Nishiyama , Masakazu Taoka
设计人： Shigeru Nishiyama , Masakazu Taoka
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14.发明授权
公开(公告)号：US5337794A
公开(公告)日：1994-08-16
申请号：US20329
申请日：1993-02-18
CPC分类号： B65B55/24 , B65B31/022
摘要： A powder filling apparatus for filling a container with powder is provided. In the powder filling apparatus, a bottle is carried into a plurality of work units moving around successively. While the work units move to work stations disposed in a circumferential direction successively, the bottle is filled with powder by equally evacuating the inside and the outside of the container and dropping powder into the container simultaneously with raising the pressure outside the container. The bottle filled with powder is then taken out from the work units successively while the work units move around.
摘要翻译： 提供一种用粉末填充容器的粉末填充装置。 在粉末填充装置中，将瓶子运送到连续移动的多个工作单元中。 当工作单元依次移动到沿圆周方向设置的工作站时，通过同时抽出容器的内部和外部并将粉末与容器中的压力升高同时将粉末落入容器中而填充粉末。 然后在工作单元移动的同时，从工作单元中取出装有粉末的瓶子。
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公开(公告)号：US5144511A
公开(公告)日：1992-09-01
申请号：US746533
申请日：1991-08-19
IPC分类号： G11B15/675 , G11B23/087
CPC分类号： G11B15/675 , G11B23/08735
摘要： A cassette casing for a magnetic tape cassette has a casing body and a slider member mounted for sliding motion between a closed position and an open position. The slider member has a pair of guide grooves formed on the outer surface thereof remote from the casing body and extending from a first end of the cassette casing toward the other end, each of the guide grooves having first and second engaging holes which are formed on the bottom of the guide groove to extend through the slider member and open to the inner surface of the same and are spaced from each other in the longitudinal direction of the guide groove. The casing body is provided with a pair of locking projections each of which is resiliently urged toward one of the guide grooves from the inner surface of the slider member and is adapted to be selectively engaged with the first and second engaging holes so that its tip portion projects into the guide groove. The locking projections is disengaged from the engaging holes by a pair of lock release projections which are provided on a surface of a cassette deck and slide along the guide grooves when the magnetic tape cassette is loaded in the cassette deck. The outer surface of the slider member which is opposed to the surface of the cassette deck on which the lock release projections are provided is cut obliquely at each side edge portion thereof from a portion close to the guide groove on the outer side thereof to the side edge.
摘要翻译： 用于磁带盒的盒壳体具有壳体和安装用于在关闭位置和打开位置之间滑动的滑块。 滑动构件具有形成在远离壳体的外表面上的一对引导槽，并且从盒壳体的第一端朝向另一端延伸，每个引导槽具有第一和第二接合孔，其形成在 引导槽的底部延伸穿过滑动构件并向其内表面开口，并且在引导槽的纵向上彼此间隔开。 壳体具有一对锁定突起，每个锁定突起从滑动构件的内表面向一个引导槽弹性地推压，并且适于与第一和第二接合孔选择性地接合，使得其顶端部分 项目进入导槽。 锁定突起通过一对锁定释放突起与接合孔分离，该锁定释放突起设置在盒式磁带的表面上，并且当盒式磁带装载在磁带盒中时沿导槽滑动。 滑动构件的与设置有锁定释放突起的盒甲板的表面相对的外表面在其每个侧边缘处从其外侧的导向槽的侧面向侧面 边缘。
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公开(公告)号：US5126190A
公开(公告)日：1992-06-30
申请号：US760308
申请日：1991-09-16
CPC分类号： D04H3/07 , B29C70/222 , B29C70/24 , D03D41/004 , Y10S428/902 , Y10T442/3195
摘要： Textile structures for producing structural members such as reinforced spars of composite material and a method for producing the textile structures. In the textile structure at least two textile planar members, or plates, are integrally joined together by textile filaments such that the planes of the members intersect each other, at least one member being formed of layers of textile filaments which extend obliquely in at least two directions in a brace fashion with respect to the longitudinal and transverse directions of the member while the remaining members are each formed of layers of textile filaments extending along the longitudinal, transverse and vertical directions of the member.The textile structures are made by disposing filament guide members of required length in a vertical direction according to a desired configuration and design density of the structures and laying out textile filaments among said filament guide members so that they move longitudinally, transversely or orthogonally to form a plurality of textile planar members. The members are joined together by extracting the filament guide members and inserting filaments in the spaces vacated by the filament guide members.
摘要翻译： 用于生产结构构件的织物结构，例如复合材料的加强筋和用于生产纺织结构的方法。 在织物结构中，至少两个织物平面构件或板通过织物丝整体地连接在一起，使得构件的平面彼此相交，至少一个构件由纺织细丝层形成，该层由至少两个 方向相对于构件的纵向和横向方向为支撑方向，而其余构件各自由沿构件的纵向，横向和垂直方向延伸的纺织细丝层形成。 织物结构通过根据结构的期望的构造和设计密度在所述长丝引导构件中布置所需长度的长丝引导构件并在所述长丝引导构件之间布置纺织细丝而制成，使得它们纵向，横向或正交地移动以形成 多个织物平面构件。 通过提取细丝引导构件并将细丝插入由细丝引导构件空出的空间中，将构件连接在一起。
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公开(公告)号：US4694702A
公开(公告)日：1987-09-22
申请号：US774804
申请日：1985-09-11
IPC分类号： G01F1/32
CPC分类号： G01F1/3254
摘要： A vortex shedding flowmeter comprises a flow passage through which a fluid flows, a bluff body arranged in the flow passage for generating Karman vortex of the fluid and provided with a pair of holes which open to respective side surfaces of the bluff body and extend toward and penetrate through one end of the bluff body for introducing a pressure change caused by the Karman vortex, a body which is an independent member from the bluff body, a pair of detecting parts provided in the body and comprising a pair of recesses provided on the body, a pair of fixed electrodes and a pair of movable electrodes provided in the recesses with a predetermined distance therebetween, a communicating hole provided in the body for communicating a pair of spaces formed between the fixed and movable electrodes, and a sealed fluid sealed in the spaces and the communicating hole, where the movable electrodes are displaced responsive to the pressure change in the fluid introduced from the bluff body and received by surfaces of the variable electrodes opposite to surfaces in contact with the sealed fluid and the fixed and movable electrodes constitute a pair of variable capacitors, and a detecting circuit for generating an electrical output responsive to changes in capacitances of the variable capacitors.
摘要翻译： 涡流脱流流量计包括流体流过的流动通道，布置在流动通道中的非流线体，用于产生流体的卡门涡流，并且设置有一对孔，该孔对非流线形体的相应侧表面开口并向 穿透非流线形体的一端，引入由卡门涡旋引起的压力变化，卡曼涡是与非流线形体无关的独立构件的一体，设在主体中的一对检测部，包括一对设置在主体上的凹部 一对固定电极和设置在所述凹部中的一对可动电极之间，其间具有预定的距离;设置在所述主体中的连通孔，用于使形成在所述固定和可动电极之间的一对空间连通;以及密封在所述固定电极中的密封流体 空间和连通孔，其中可移动电极响应于从非流线形体引入的流体的压力变化而被移位和接收 由可变电极与与密封流体接触的表面相对的表面和固定和可移动电极构成一对可变电容器，以及用于响应于可变电容器的电容变化而产生电输出的检测电路。
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公开(公告)号：US08962854B2
公开(公告)日：2015-02-24
申请号：US14240144
申请日：2012-08-22
申请人： Shigeru Nishiyama , Tsuyoshi Saito , Shojiro Maki , Haruki Niwa
发明人： Shigeru Nishiyama , Tsuyoshi Saito , Shojiro Maki , Haruki Niwa
IPC分类号： C07D417/04 , C07D417/06 , C07D277/10 , C07D277/66 , C12Q1/66 , C07D277/12 , A61K49/00
CPC分类号： C12Q1/66 , A61K49/003 , C07D277/12 , C07D277/66 , C07D417/04 , C07D417/06
摘要： An object of the present invention to provide a firefly luciferin and firefly luciferin analog that are modified to maintain luminescent activity by luciferase in a firefly bioluminescent system. In particular, it is an object of the present invention to provide a new luminescent substrate for which the emission wavelength in a firefly bioluminescent system is shifted to a longer wavelength than that of a conventional luminescent substrate. The present invention provides a luciferin in which the benzothiazole ring moiety has been modified at the 7-position, a luciferin analog in which the benzene ring moiety has been modified at the 6-position, and a luciferin analog in which the 6-(dialkylamino)-2-naphthalenyl moiety has been modified at the 5-position.
摘要翻译： 本发明的目的是提供萤火虫荧光素和萤火虫萤光素类似物，其被修饰以通过荧光素酶在萤火虫生物发光系统中维持发光活性。 特别地，本发明的目的是提供一种荧光生物发光系统的发光波长比现有的发光基板移动到更长的波长的新的发光基板。 本发明提供了其中苯并噻唑环部分在7位被修饰的荧光素，其中苯环部分已经在6位被修饰的萤光素类似物和其中6-（二烷基氨基 ）-2-萘基部分已经在5位修饰。
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公开(公告)号：US20140221665A1
公开(公告)日：2014-08-07
申请号：US14240144
申请日：2012-08-22
申请人： Shigeru Nishiyama , Tsuyoshi Saito , Shojiro Maki , Haruki Niwa
发明人： Shigeru Nishiyama , Tsuyoshi Saito , Shojiro Maki , Haruki Niwa
IPC分类号： C12Q1/66
CPC分类号： C12Q1/66 , A61K49/003 , C07D277/12 , C07D277/66 , C07D417/04 , C07D417/06
摘要： An object of the present invention to provide a firefly luciferin and firefly luciferin analog that are modified to maintain luminescent activity by luciferase in a firefly bioluminescent system. In particular, it is an object of the present invention to provide a new luminescent substrate for which the emission wavelength in a firefly bioluminescent system is shifted to a longer wavelength than that of a conventional luminescent substrate. The present invention provides a luciferin in which the benzothiazole ring moiety has been modified at the 7-position, a luciferin analog in which the benzene ring moiety has been modified at the 6-position, and a luciferin analog in which the 6-(dialkylamino)-2-naphthalenyl moiety has been modified at the 5-position.
摘要翻译： 本发明的目的是提供萤火虫荧光素和萤火虫萤光素类似物，其被修饰以通过荧光素酶在萤火虫生物发光系统中维持发光活性。 特别地，本发明的目的是提供一种荧光生物发光系统的发光波长比现有的发光基板移动到更长的波长的新的发光基板。 本发明提供了其中苯并噻唑环部分在7位被修饰的荧光素，其中苯环部分已经在6位被修饰的萤光素类似物和其中6-（二烷基氨基 ）-2-萘基部分已经在5位修饰。
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公开(公告)号：US08557167B2
公开(公告)日：2013-10-15
申请号：US13122571
申请日：2009-11-18
IPC分类号： B28B3/00
CPC分类号： B29C43/3642 , B29C43/12 , B29C73/025 , B29C73/10 , B29C2043/3644 , B29K2105/0002 , B29K2105/0872
摘要： In manufacturing composite material by curing fluid, strength deterioration of the composite material due to repair before the fluid is cured is reduced. A suction hole is formed in a bag film (3) for sealing a space for fibers being impregnated with resin, after start of impregnation. The suction hole is covered by a plate (56) with holes (57). The resin is sucked from the space through the plate (56). According to such composite material manufacturing method, a defect, which occurs during fibers are impregnated with resin, can be repaired before the resin is cured without causing disorder and damage in the fibers. In a composite material formed from one repaired in the above way, the repaired portion is strong, namely, there is no strength deterioration due to repair after curing, and thus, the material is preferred as compared with a composite material which is repaired after resin is cured.
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