公开(公告)号：US20100204536A1

公开(公告)日：2010-08-12

申请号：US12557040

申请日：2009-09-10

申请人： L. Michael Cutrer ,  Leigh Spotten ,  Joseph Wong ,  Fredrick Winch

发明人： L. Michael Cutrer ,  Leigh Spotten ,  Joseph Wong ,  Fredrick Winch

IPC分类号： A61M36/12

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： A brachytherapy device for treating tissue within a cavity of a body. The device may include a first set of tubes configured to be inserted into the cavity through an opening at the surface of the body. Each of the tubes may have an external end and an interior channel beginning at the external end that is configured to receive radioactive material. The external ends of the tubes may be bundled together. The tubes may be of a length that causes the external ends to be near the opening in the surface of the body while the tubes are in the cavity. A seal may be configured to prevent fluid that originates from the cavity from entering into the external ends of the tubes while they are near the opening in the surface of the body. The seal may include a gasket that is pressed against the external ends of the tubes. The gasket may have openings that align with channels within the external ends of the tubes.

摘要翻译： 一种用于治疗身体空腔内的组织的近距离放射治疗装置。 该装置可以包括构造成通过身体表面处的开口插入空腔中的第一组管。 每个管可以具有外部端和从外部端开始的内部通道，其构造成接收放射性材料。 管的外端可以捆扎在一起。 管可以具有这样的长度，即当管在空腔中时，外端在壳体表面的开口附近。 密封件可以构造成防止来自腔的流体在它们靠近体表面的开口处时进入管的外端。 密封件可以包括被压靠在管的外端的垫圈。 垫圈可以具有与管的外端内的通道对准的开口。

公开(公告)号：US20080161633A1

公开(公告)日：2008-07-03

申请号：US12037534

申请日：2008-02-26

申请人： L. Michael Cutrer ,  Richard A. Terwilliger ,  Joe Wong ,  Frederick Winch

发明人： L. Michael Cutrer ,  Richard A. Terwilliger ,  Joe Wong ,  Frederick Winch

IPC分类号： A61M36/04

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： A brachytherapy device may include an expandable outer cage, an expandable inner cage positioned within the outer cage and configured to receive radioactive material at its perimeter, and a movable actuator configured to cause the outer and inner cages to expand simultaneously in response to movement of the actuator between certain positions while maintaining a substantially constant separation distance between the outer and inner cages.

摘要翻译： 近距离放射治疗装置可以包括可扩张的外笼，位于外笼内并被配置为在其外周处接收放射性物质的可扩展的内笼，以及可移动的致动器，该致动器构造成使得外壳和内笼同时响应于 致动器在某些位置之间，同时保持外笼和内笼之间的基本恒定的间隔距离。

公开(公告)号：US08157717B2

公开(公告)日：2012-04-17

申请号：US12544101

申请日：2009-08-19

申请人： L. Michael Cutrer ,  Richard A. Terwilliger ,  Joe Wong ,  Fredrick Wintch

发明人： L. Michael Cutrer ,  Richard A. Terwilliger ,  Joe Wong ,  Fredrick Wintch

IPC分类号： A61N5/00

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： A brachytherapy device may include an expandable outer cage, an expandable inner cage positioned within the outer cage and configured to receive radioactive material at its perimeter, and a movable actuator configured to cause the outer and inner cages to expand simultaneously in response to movement of the actuator between certain positions while maintaining a substantially constant separation distance between the outer and inner cages.

摘要翻译： 近距离放射治疗装置可以包括可扩张的外笼，位于外笼内并被配置为在其外周处接收放射性物质的可扩展的内笼，以及可移动的致动器，该致动器构造成使得外壳和内笼同时响应于 致动器在某些位置之间，同时保持外笼和内笼之间的基本恒定的间隔距离。

公开(公告)号：US06755775B2

公开(公告)日：2004-06-29

申请号：US09943168

申请日：2001-08-30

申请人： Dan Kalas ,  David Bossi ,  L. Michael Cutrer

发明人： Dan Kalas ,  David Bossi ,  L. Michael Cutrer

IPC分类号： A61N500

CPC分类号： A61N5/1007 ,  A61N5/1027 ,  A61N2005/101

摘要： The present invention relates to an apparatus and method for loading radioactive brachytherapy seeds into a seed cartridge for use with an applicator. Embodiments of the apparatus according to the present invention may include a number of contact points of a size and shape designed to conform to the main body of a brachytherapy seed. The apparatus may hold the seeds until the seeds are placed within a channel of the seed cartridge, at which point the seeds may be released from the contact sites by the application of a force to the seeds or by some other mechanism. The apparatus may be made from a flexible material so that the seeds may be released by the application of a tension force. According to embodiments of the method of loading the seed cartridge, seeds in the loader may be positioned in relation to the body of the loading apparatus and the ends of the seeds may be aligned with the channel of the seed cartridge. A seed may be placed in the channel so that a gripping portion of the loading device protrudes from an access portion of the channel. The apparatus may include gripping features so that the loading apparatus can be held firmly during the loading process.

摘要翻译： 本发明涉及一种用于将放射性近距离放射治疗种子装载到用于施用器的种子筒中的装置和方法。 根据本发明的装置的实施例可以包括大小和形状的多个接触点，其设计成符合近距离放射治疗种子的主体。 装置可以保持种子，直到种子放置在种子仓的通道内，此时可以通过向种子施加力或通过某种其它机制将种子从接触位点释放。 该装置可以由柔性材料制成，使得可以通过施加张力来释放种子。 根据装载种子盒的方法的实施例，装载机中的种子可以相对于装载装置的主体定位，并且种子的端部可以与种子仓的通道对齐。 种子可以放置在通道中，使得装载装置的夹持部分从通道的通道部分突出。 该装置可以包括夹持特征，使得装载装置能够在装载过程中牢固地保持。

公开(公告)号：US06881183B2

公开(公告)日：2005-04-19

申请号：US10692223

申请日：2003-10-23

申请人： L. Michael Cutrer

发明人： L. Michael Cutrer

IPC分类号： A61K49/04 ,  A61K51/12 ,  A61M36/12 ,  A61N5/10 ,  G21G4/06 ,  G21G4/08 ,  A61N5/00

CPC分类号： G21G4/06 ,  A61K49/0409 ,  A61K51/1282 ,  A61N5/1027 ,  A61N2005/1019 ,  A61N2005/1024 ,  G21G4/08

摘要： A radioactive seed which discloses the orientation and the location of the seed when the seed is exposed to X-ray photography is provided. The seed contains multiple X-ray detectable markers which will disclose the orientation and the location of the seed when the seed is exposed to X-ray photography. The seed can also have a single marker which wraps around the external surface of the seed or wraps around a carrier body within the seed. The single marker will also disclose the orientation as well as the location of the seed.

摘要翻译： 提供了当种子暴露于X射线摄影时公开了种子的取向和位置的放射性种子。 种子包含多个X射线可检测标记，当种子暴露于X射线摄影时，它们将公开种子的取向和位置。 种子还可以具有围绕种子的外表面包裹的单个标记物，或者包裹在种子内的载体身上。 单个标记还将公开种子的取向和位置。

公开(公告)号：US06503186B1

公开(公告)日：2003-01-07

申请号：US09280097

申请日：1999-03-29

申请人： L. Michael Cutrer

发明人： L. Michael Cutrer

IPC分类号： A61N500

CPC分类号： G21G4/06 ,  A61K49/0409 ,  A61K51/1282 ,  A61N5/1027 ,  A61N2005/1019 ,  A61N2005/1024 ,  G21G4/08

摘要： A radioactive seed which discloses the orientation and the location of the seed when the seed is exposed to X-ray photography is provided. The seed contains multiple X-ray detectable markers which will disclose the orientation and the location of the seed when the seed is exposed to X-ray photography. The seed can also have a single marker which wraps around the external surface of the seed or wraps around a carrier body within the seed. The single marker will also disclose the orientation as well as the location of the seed.

摘要翻译： 提供了当种子暴露于X射线摄影时公开了种子的取向和位置的放射性种子。 种子包含多个X射线可检测标记，当种子暴露于X射线摄影时，它们将公开种子的取向和位置。 种子还可以具有围绕种子的外表面包裹的单个标记物，或者包裹在种子内的载体身上。 单个标记还将公开种子的取向和位置。

公开(公告)号：US06440058B1

公开(公告)日：2002-08-27

申请号：US09648849

申请日：2000-08-25

申请人： L. Michael Cutrer

发明人： L. Michael Cutrer

IPC分类号： A61N500

CPC分类号： A61K49/0409 ,  A61K51/1282 ,  A61N5/1027 ,  A61N2005/1019 ,  A61N2005/1024 ,  G21G4/06 ,  G21G4/08

摘要： A system and method of treating an affected region of diseased tissue in a patient is described. A plurality of first radioactive seeds and a plurality of second radioactive seeds are implanted in the affected region. The first radioactive seeds each have one or more X-ray detectable markers providing a first X-ray detectable signature and the second radioactive seeds have one or more X-ray detectable markers providing a second X-ray detectable signature. An X-ray image of the affected region, including the first and second radioactive seeds implanted therein, provides representations of the first and second X-ray signatures which are visibly distinguishable. Representations of the first X-ray signature may then be associated with implanted seeds having a radioisotope source or dosage of the first radioactive seeds and representations of the second X-ray signature may then be associated with implanted seeds having a radioisotope source or dosage of the second radioactive seeds.

摘要翻译： 描述了治疗患者的患病组织的受影响区域的系统和方法。 多个第一放射性种子和多个第二放射性种子植入受影响的区域。 第一放射性种子各具有一个或多个X射线可检测标记，提供第一X射线可检测标记，第二放射性种子具有提供第二X射线可检测标记的一个或多个X射线可检测标记。 受影响区域的X射线图像，包括植入其中的第一和第二放射性种子，提供可明显区分的第一和第二X射线特征的表示。 然后可以将第一X射线签名的表示与具有放射性同位素源或第一放射性种子的剂量的植入种子相关联，并且第二X射线签名的表示可以与具有放射性同位素源或剂量的植入种子相关联 第二放射性种子。

公开(公告)号：US20100025598A1

公开(公告)日：2010-02-04

申请号：US12533392

申请日：2009-07-31

申请人： Jason Short ,  Mike Palatas ,  L. Michael Cutrer ,  Jeff Gabler

发明人： Jason Short ,  Mike Palatas ,  L. Michael Cutrer ,  Jeff Gabler

IPC分类号： G21G4/00

CPC分类号： G21G4/06

摘要： Method and/or system for forming a radiation flood source. The radiation flood source includes a paper sheet, a pigmentless radioactive fill printed on the paper sheet, and a pigmented border printed on the paper sheet and around the pigmentless radioactive fill. In one embodiment the radiation flood source is formed by preparing a radioactive isotope carrier solution; loading the radioactive isotope carrier solution into a radioactive isotope carrier solution cartridge; loading a separate border cartridge into a plotter; selecting and configuring a shape of an active area; setting a border to be placed around the active area; printing the active area by utilizing the radioactive isotope carrier solution cartridge on a sheet substrate; and printing the border by utilizing the separate border cartridge on the sheet substrate.

摘要翻译： 用于形成辐射源的方法和/或系统。 辐射源源包括印刷在纸张上的纸片，无颜料的放射性填充物，以及印刷在纸张上并且在无颜料的放射性填料周围的着色边界。 在一个实施例中，通过制备放射性同位素载体溶液形成辐射泛洪源; 将放射性同位素载体溶液装入放射性同位素载体溶液中; 将单独的边框装载到绘图仪中; 选择和配置活动区域的形状; 将边界设置在活动区域​​周围; 通过利用片状基材上的放射性同位素载体溶液筒印刷活性区域; 并通过利用片材基板上的分离的边框来打印边框。

公开(公告)号：US06638207B2

公开(公告)日：2003-10-28

申请号：US10271270

申请日：2002-10-15

申请人： L. Michael Cutrer

发明人： L. Michael Cutrer

IPC分类号： A61N500

CPC分类号： G21G4/06 ,  A61K49/0409 ,  A61K51/1282 ,  A61N5/1027 ,  A61N2005/1019 ,  A61N2005/1024 ,  G21G4/08

摘要： A radioactive seed which discloses the orientation and the location of the seed when the seed is exposed to X-ray photography is provided. The seed contains multiple X-ray detectable markers which will disclose the orientation and the location of the seed when the seed is exposed to X-ray photography. The seed can also have a single marker which wraps around the external surface of the seed or wraps around a carrier body within the seed. The single marker will also disclose the orientation as well as the location of the seed.

公开(公告)号：US08253120B2

公开(公告)日：2012-08-28

申请号：US12533392

申请日：2009-07-31

申请人： Jason Short ,  Mike Palatas ,  L. Michael Cutrer ,  Jeff Gabler

发明人： Jason Short ,  Mike Palatas ,  L. Michael Cutrer ,  Jeff Gabler

IPC分类号： G21G4/00

CPC分类号： G21G4/06

摘要： Method and/or system for forming a radiation flood source. The radiation flood source includes a paper sheet, a pigmentless radioactive fill printed on the paper sheet, and a pigmented border printed on the paper sheet and around the pigmentless radioactive fill. In one embodiment the radiation flood source is formed by preparing a radioactive isotope carrier solution; loading the radioactive isotope carrier solution into a radioactive isotope carrier solution cartridge; loading a separate border cartridge into a plotter; selecting and configuring a shape of an active area; setting a border to be placed around the active area; printing the active area by utilizing the radioactive isotope carrier solution cartridge on a sheet substrate; and printing the border by utilizing the separate border cartridge on the sheet substrate.

摘要翻译： 用于形成辐射源的方法和/或系统。 辐射源源包括印刷在纸张上的纸片，无颜料的放射性填充物，以及印刷在纸张上并且在无颜料的放射性填料周围的着色边界。 在一个实施例中，通过制备放射性同位素载体溶液形成辐射泛洪源; 将放射性同位素载体溶液装入放射性同位素载体溶液中; 将单独的边框装载到绘图仪中; 选择和配置活动区域的形状; 将边界设置在活动区域​​周围; 通过利用片状基材上的放射性同位素载体溶液筒印刷活性区域; 并通过利用片材基板上的分离的边框来打印边框。