公开(公告)号：US20240189620A1

公开(公告)日：2024-06-13

申请号：US18553713

申请日：2022-04-28

申请人： Arizona Board of Regents on Behalf of the University of Arizona ,  Dignity Health

发明人： Jennifer Kehlet Barton ,  Nitika Thawani ,  Danielle Ann Gelb ,  Audrey Tamra Cohen ,  Hiram Olivas ,  Jacob Emanuel Mapp ,  Ryan Stephen Zenhausern ,  Jesus Daniel Vargas Lopez

IPC分类号： A61N5/10 ,  A61M25/09 ,  A61M25/10

CPC分类号： A61N5/1014 ,  A61M25/09 ,  A61M25/1011 ,  A61N2005/1003 ,  A61N2005/1008 ,  A61N2005/1018

摘要： A system includes a device associated with an endoscopy guided procedure including a housing defining a housing channel with at least a portion of the housing configured for deployment within a cavity. The device further includes a plurality of bodies defining respective channels defined within the housing. The housing defines a longitudinal axis, and the plurality of channels extends throughout the housing around the longitudinal axis. Each of the plurality of channels accommodates selective activation of radiation emittance from a predetermined different position along the housing via one or more radiation elements such that the plurality of channels collectively provides a predetermined spatial distribution of a radiation treatment to a target area along the cavity.

公开(公告)号：US11801021B2

公开(公告)日：2023-10-31

申请号：US17682069

申请日：2022-02-28

申请人： NU-RISE Lda

发明人： Luis Miguel da Conceição Moutinho ,  Joana Isabel Ferreira dos Santos Melo

IPC分类号： A61B6/00 ,  A61N5/10 ,  A61N5/06

CPC分类号： A61B6/42 ,  A61B6/40 ,  A61B6/44 ,  A61N5/1014 ,  A61N5/1071 ,  A61B2562/0257 ,  A61B2562/0271 ,  A61N2005/063 ,  A61N2005/1018

摘要： Interstitial brachytherapy is a cancer treatment in which radioactive material is placed closely to the target tissue of the affected site using an afterloader (HDR-brachytherapy) or manually (LDR- and PDR-brachytherapy). For HDR-brachytherapy, the accuracy of this placement is calibrated using an external reference system that locates the radioactive material according to the radiation levels measured at locations around the source. At each of these locations, a scintillator produces light when irradiated by the radioactive material. This light is proportional to the level of radiation at each location. The light produced by each scintillator is converted to an electrical signal that is proportional to the light and the radiation level at each location. The radioactive material is located according to the plurality of electrical signals.

公开(公告)号：US20170304644A1

公开(公告)日：2017-10-26

申请号：US15517740

申请日：2015-10-16

申请人： KONINKLIJKE PHILIPS N.V.

发明人： JOCHEN KRUECKER ,  SHYAM BHARAT ,  EHSAN DEHGHAN MARVAST ,  CYNTHIA MING-FU KUNG ,  ANANTH RAVI ,  FALK UHLEMANN ,  THOMAS ERIK AMTHOR

IPC分类号： A61N5/01 ,  A61N5/10

CPC分类号： A61N5/01 ,  A61B34/20 ,  A61B90/37 ,  A61B2034/2051 ,  A61B2090/364 ,  A61N5/1027 ,  A61N5/103 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1018 ,  A61N2005/1058 ,  A61N2005/1074

摘要： An interventional therapy system (100, 200, 300, 900) may include at least one catheter configured for insertion within an object of interest (OOI); and at least one controller (102, 202, 910) which: obtains a reference image dataset (540) comprising a plurality of image slices which form a three-dimensional image of the OOI, defines restricted areas (RAs) within the reference image dataset, determines location constraints for the at least one catheter in accordance with at least one of planned catheter intersection points, a peripheral boundary of the OOI and the RAs defined in the reference dataset, determines at least one of a position and an orientation of the distal end of the at least one catheter, and/or determines a planned trajectory for the at least one catheter in accordance with the determined at least one position and orientation for the at least one catheter and the location constraints.

公开(公告)号：US20160375266A1

公开(公告)日：2016-12-29

申请号：US15170928

申请日：2016-06-01

申请人： Nucletron Operations B.V.

发明人： Johann KINDLEIN

IPC分类号： A61N5/10

CPC分类号： A61N5/1007 ,  A61B2034/2051 ,  A61N5/103 ,  A61N5/1048 ,  A61N2005/1008 ,  A61N2005/1012 ,  A61N2005/1018 ,  A61N2005/1058

摘要： The invention relates to a method for identifying the location at least one treatment channel from a group of a plurality of treatment channels as wells as a system for effecting radiation treatment on a pre-selected anatomical portion of an animal body.According to the invention the identifying method being characterized by the steps of A selecting at least one of said plurality of treatment channels; B reconstructing the actual location of said selected treatment channel relative to said animal body; and C comparing said reconstructed location said pre-planned plurality of locations. Furthermore the system according to the invention is characterized in that identifying means are present for identifying the location of at least one treatment channel from said group of said plurality of inserted treatment channels and comparing said identified location with one or more of said pre-planned locations present in said treatment plan.

摘要翻译： 此外，根据本发明的系统的特征在于，存在用于识别来自所述多个插入的治疗通道的所述组的至少一个治疗通道的位置的识别装置，并且将所述识别的位置与一个或多个所述预先计划的位置进行比较 出现在治疗计划中。

公开(公告)号：US20160271379A1

公开(公告)日：2016-09-22

申请号：US14907679

申请日：2014-07-28

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Jean POULIOT ,  Ken GOLDBERG ,  I-Chow HSU ,  J. Adam M. CHNHA ,  Animesh GARG ,  Sachin PATEL ,  Pieter ABBEEL ,  Timmy SIAUW

IPC分类号： A61M31/00 ,  A61B8/08 ,  A61B6/03 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61M31/002 ,  A61B6/032 ,  A61B6/037 ,  A61B8/085 ,  A61B18/14 ,  A61B18/1815 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/0212 ,  A61B2018/1861 ,  A61B2090/3983 ,  A61F2007/126 ,  A61M2207/00 ,  A61N5/0603 ,  A61N5/062 ,  A61N5/1014 ,  A61N5/1016 ,  A61N5/1049 ,  A61N7/022 ,  A61N2005/0606 ,  A61N2005/0608 ,  A61N2005/0611 ,  A61N2005/1018 ,  A61N2005/1094 ,  B29C64/112 ,  B29C64/20 ,  B29K2101/12 ,  B29K2995/0056 ,  B29L2031/753 ,  B33Y10/00 ,  B33Y80/00

摘要： The present invention offers an alternative for cancer treatment where radiation, thermotherapy, or another therapeutic modality must be delivered to an internal cavity of a subject, for example to treat mouth, anal, cervical, and vaginal cancers. The invention is a new approach that builds on recent results in 3D printing and steerable needle motion planning to create customized implants containing customized curvature-constrained internal channels that fit securely, minimize air gaps, and precisely guide treatment sources through internal printed channels to accurately reach tumors and minimize damage to healthy tissue.

摘要翻译： 本发明提供了用于癌症治疗的替代方案，其中辐射，热疗或其他治疗方式必须被递送到受试者的内腔，例如治疗口腔，肛门，子宫颈和阴道癌。 本发明是基于3D打印和可转向针运动规划的最新结果的新方法，以创建定制的植入物，其包含定制的曲率受限的内部通道，其可安全地安装，最小化气隙，并且通过内部印刷通道精确地引导治疗源以准确地达到 肿瘤并尽可能减少对健康组织的损伤。

公开(公告)号：US20150190653A1

公开(公告)日：2015-07-09

申请号：US14412824

申请日：2013-07-15

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Shyam Bharat ,  Ehsan Dehghan Marvast ,  Jochen Kruecker ,  Cynthia Ming-fu Kung

IPC分类号： A61N5/10

CPC分类号： A61N5/1007 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/378 ,  A61N5/1027 ,  A61N5/103 ,  A61N2005/1012 ,  A61N2005/1018

摘要： The invention relates to a determination apparatus for determining the pose and shape of an introduction element like a catheter within a living being, wherein the introduction element (12) is adapted to be used by a brachytherapy apparatus for introducing a radiation source (10) close to a target object (11) to be treated. A position determination element (27) like guidewire (20) with an electromagnetic tracking element (16) is introduced into the introduction element (12) such that it is arranged at different locations within the introduction element (12), wherein the positions of the position determination element (27) within the introduction element (12) are determined. The determined positions are then acquired depending on the determined positions for determining the pose and shape of the introduction element within the living being. This can lead to a determination procedure with reduced user interaction, thereby simplifying the determination procedure for the user.

摘要翻译： 本发明涉及一种确定装置，用于确定诸如导管在内的导入元件的姿势和形状，其中引入元件（12）适于由近距离放射治疗装置使用以将辐射源（10）接近 到待处理的目标物体（11）。 具有电磁跟踪元件（16）的类似导丝（20）的位置确定元件（27）被引入到引入元件（12）中，使得其布置在引入元件（12）内的不同位置处，其中 确定引入元件（12）内的位置确定元件（27）。 然后根据用于确定生物体内的引入元件的姿势和形状的确定位置获取确定的位置。 这可以导致具有减少的用户交互的确定过程，从而简化了用户的确定过程。

公开(公告)号：US08858415B2

公开(公告)日：2014-10-14

申请号：US12764892

申请日：2010-04-21

申请人： Eduardo Chi Sing ,  George D. Hermann ,  Mark A. Cole ,  Mark A. Richart ,  Than Nguyen ,  Gail S. Lebovic

发明人： Eduardo Chi Sing ,  George D. Hermann ,  Mark A. Cole ,  Mark A. Richart ,  Than Nguyen ,  Gail S. Lebovic

IPC分类号： A61M36/12 ,  A61N5/10

CPC分类号： A61N5/1015 ,  A61N2005/1018

摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

摘要翻译： 用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。 细长构件可在折叠和膨胀构型之间移动。 在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。 细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

公开(公告)号：US20140121444A1

公开(公告)日：2014-05-01

申请号：US14063527

申请日：2013-10-25

申请人： Nucletron Operations B.V.

发明人： Wilhelmus Petrus Martinus Maria van Erp ,  Tommy Robert Oscar Martens ,  Gaetan Stephan Marie van Wijck ,  Cor van de Wardt

IPC分类号： A61N5/10

CPC分类号： A61N5/1016 ,  A61M2025/028 ,  A61N5/1007 ,  A61N5/1014 ,  A61N5/1015 ,  A61N5/1027 ,  A61N2005/1008 ,  A61N2005/1009 ,  A61N2005/1018

摘要： A modular applicator for enabling a brachytherapy treatment comprising a central element and one or more of peripheral elements, wherein the central element is adapted with a fixation mechanism having a core for affixing the said peripheral elements thereto, wherein the fixation mechanism prevents a rotational displacement of the peripheral elements attached to the core of the fixation element with respect to the central element.

摘要翻译： 一种用于实现包括中心元件和一个或多个周边元件的近距离放射线治疗的模块化施加器，其中所述中心元件适于具有用于将所述周边元件固定到其上的芯的固定机构，其中所述固定机构防止 周边元件相对于中心元件附接到固定元件的芯部。

公开(公告)号：US08636637B2

公开(公告)日：2014-01-28

申请号：US13571495

申请日：2012-08-10

申请人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

发明人： Paul Lubock ,  Michael L. Jones ,  Frank R. Louw

IPC分类号： A61N5/00

CPC分类号： A61N5/1014 ,  A61N5/1002 ,  A61N5/1015 ,  A61N2005/1003 ,  A61N2005/1004 ,  A61N2005/1005 ,  A61N2005/1018 ,  A61N2005/1024

摘要： The disclosure describes devices and methods for asymmetrical irradiation at a body cavity or site, such as after removal of tissue, e.g. biopsy or cancer. One device includes a lumen which is off-set or off-settable from a longitudinal axis to increase the intensity of radiation received from a radiation source by a first tissue portion surrounding the body cavity and to reduce or minimize radiation received by a second tissue portion (e.g. healthy tissue) surrounding the body cavity.

摘要翻译： 本公开描述了用于在体腔或部位不对称照射的装置和方法，例如在去除组织之后，例如， 活检或癌症。 一个装置包括从纵向轴线偏移或不可固定的内腔，以增加围绕体腔的第一组织部分从辐射源接收的辐射的强度，并且减少或最小化由第二组织部分接收的辐射 （例如健康组织）。

公开(公告)号：US20130144105A1

公开(公告)日：2013-06-06

申请号：US13750596

申请日：2013-01-25

申请人： SenoRx, Inc.

发明人： George M. Acosta ,  Paul Lubock

IPC分类号： A61N5/10

CPC分类号： A61N5/1015 ,  A61F7/123 ,  A61M25/10 ,  A61M25/1034 ,  A61M25/1036 ,  A61M2025/0036 ,  A61M2025/004 ,  A61N1/403 ,  A61N2005/1018

摘要： The disclosure describes a device for asymmetrical irradiation of a body cavity or site, such as after removal of tissue, e.g. biopsy or lumpectomy. The device includes an elongated tubular shaft having an inner lumen and a tubular wall with a plurality of lumens extending within the wall which are configured for receiving a radiation source. The distal portion of the tubular shaft is cut into a plurality of longitudinally separated wall segments with a lumen extending within at least one of the wall segments. A support member is positioned within the separated wall segments to support and position the wall segments in a desired configuration for brachytherapy. An expandable member such as an inflatable balloon is mounted on the distal shaft portion about the separated wall segments wall which when inflated secures the distal shaft portion within a desired intracorporeal site for brachytherapy treatment.

摘要翻译： 本公开描述了用于体腔或部位的不对称照射的装置，例如在去除组织之后，例如， 活检或肿瘤切除术。 该装置包括细长的管状轴，其具有内腔和具有在壁内延伸的多个内腔的管状壁，其构造成用于接收辐射源。 管状轴的远端部分被切割成多个纵向分离的壁段，其中内腔在至少一个壁段内延伸。 支撑构件被定位在分离的壁段内以支撑和定位所需的构造的壁段用于近距离放射治疗。 诸如可膨胀气囊的可膨胀构件围绕分离的壁段壁安装在远端轴部分上，当将膨胀时将远端轴部分固定在期望的体内位置以进行近距离放射疗法治疗。