公开(公告)号：US20170145214A1

公开(公告)日：2017-05-25

申请号：US15423890

申请日：2017-02-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kyle GEE ,  Upinder SINGH ,  Aleksey RUKAVISHNIKOV ,  Daniel BEACHAM ,  Shih-Jung HUANG ,  Michael JANES ,  Wenjun ZHOU

IPC: C09B11/24 ,  G01N33/84 ,  G01N33/58

CPC classification number: C09B11/24 ,  A61K49/0041 ,  C07D311/90 ,  G01N33/5005 ,  G01N33/582 ,  G01N33/84

Abstract: Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.