公开(公告)号：US20170333457A1

公开(公告)日：2017-11-23

申请号：US15671360

申请日：2017-08-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Brian AGNEW ,  Upinder SINGH ,  Scott GRECIAN

IPC: A61K31/655 ,  A61K31/7008 ,  C12N7/00

CPC classification number: A61K31/655 ,  A61K31/7008 ,  C12N7/00 ,  C12N2710/14151 ,  C12N2710/14163 ,  C12N2740/16051 ,  C12N2740/16063

Abstract: Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. Also, provided are methods of tracking a virus in vivo, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. The azide-modified biomolecules may be combined with a pharmaceutically acceptable excipient to produce a pharmaceutical composition, optionally containing another anti-viral agent and/or a delivery agent, such as a liposome.

公开(公告)号：US20170145214A1

公开(公告)日：2017-05-25

申请号：US15423890

申请日：2017-02-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Kyle GEE ,  Upinder SINGH ,  Aleksey RUKAVISHNIKOV ,  Daniel BEACHAM ,  Shih-Jung HUANG ,  Michael JANES ,  Wenjun ZHOU

IPC: C09B11/24 ,  G01N33/84 ,  G01N33/58

CPC classification number: C09B11/24 ,  A61K49/0041 ,  C07D311/90 ,  G01N33/5005 ,  G01N33/582 ,  G01N33/84

Abstract: Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.

公开(公告)号：US20160290994A1

公开(公告)日：2016-10-06

申请号：US15090529

申请日：2016-04-04

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Uma LAKSHMIPATHY ,  Upinder SINGH ,  Scott GRECIAN ,  Rene QUINTANILLA ,  Kyle GEE ,  Mahendra RAO

IPC: G01N33/50 ,  G01N1/30 ,  G01N33/58

CPC classification number: G01N33/5005 ,  C09B11/24 ,  C09B19/00 ,  C09B21/00 ,  C09B57/00 ,  C09B57/02 ,  C12Q1/42 ,  C12Y301/03001 ,  G01N1/30 ,  G01N33/5073 ,  G01N33/581 ,  G01N33/582 ,  G01N33/586 ,  G01N2001/302 ,  G01N2333/916

Abstract: The invention relates to novel substrates and methods for staining live stem cells. The stain may be used to identify induced pluripotent stem cell colonies during the process of somatic cell reprogramming.