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Patent Agency Ranking
公开(公告)号：US20180222855A1
公开(公告)日：2018-08-09
申请号：US15894057
申请日：2018-02-12
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Wenjun ZHOU , Kyle GEE , Yolanda TENNICO , Peter SLADE , Hee Chol KANG , Shaheer KHAN , Brian EVANS , James STRAY
IPC: C07C309/47 , C07D311/84 , C07C309/51 , G01N33/58
Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.
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公开(公告)号：US20190309341A1
公开(公告)日：2019-10-10
申请号：US16306609
申请日：2017-06-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle GEE , Wenjun ZHOU , Shih-Jung HUANG , Monica TOMASZEWSKI
Abstract: Provided herein are compounds, enzyme substrates, compositions, kits, uses, and methods for detecting the presence or absence of a caspase enzyme, measuring the activity of a caspase enzyme, or detecting the presence or absence of apoptosis. The detection or measurement can occur through intracellular cleavage of a compound or enzyme substrate, which can lead to an increase in fluorescence, e.g., in the violet or red channel, through liberation of a nucleic acid binding dye from a peptide, such as liberation of a DNA-binding dye from a negatively charged peptide comprising a sequence recognized and cleaved by a caspase
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公开(公告)号：US20170145214A1
公开(公告)日：2017-05-25
申请号：US15423890
申请日：2017-02-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle GEE , Upinder SINGH , Aleksey RUKAVISHNIKOV , Daniel BEACHAM , Shih-Jung HUANG , Michael JANES , Wenjun ZHOU
CPC classification number: C09B11/24 , A61K49/0041 , C07D311/90 , G01N33/5005 , G01N33/582 , G01N33/84
Abstract: Disclosed herein are compounds, compositions, methods and kits for detecting pH in samples using pH-sensitive fluorescent dyes. The compounds disclosed herein are novel xanthene-derivative dyes comprising an aniline moiety with one or more electron donating groups, which dyes are for detecting pH in samples either in vitro or in vivo. Also described herein are processes for preparing said dyes for use in the disclosed compositions, methods and kits.
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公开(公告)号：US20170369431A1
公开(公告)日：2017-12-28
申请号：US15529437
申请日：2015-12-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Wenjun ZHOU , Kyle GEE , Yolanda TENNICO , Peter SLADE , Hee Chol KANG , Shaheer KHAN , Brian EVANS , James STRAY
IPC: C07C309/47 , G01N33/58 , C07D311/84 , C07C309/51 , C07C2603/50
CPC classification number: C07C309/47 , C07C309/51 , C07C2603/50 , C07D311/84 , G01N33/582 , G01N2400/10
Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.
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公开(公告)号：US20170045496A1
公开(公告)日：2017-02-16
申请号：US15304800
申请日：2015-05-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Kyle GEE , Hee Chol KANG , Wenjun ZHOU , Bradley DUBBELS , Michael OLSZOWY , Michael O'GRADY
CPC classification number: G01N33/5005 , C07C309/61 , C07C2603/24 , C07D471/04 , C07K16/2812 , C09B11/28 , G01N33/5014 , G01N33/5044
Abstract: Described herein are fluorescent compounds and methods and comprising these compounds. The compounds disclosed herein are carbopyronine reagents that fluoresce in the red portion of the UV/VIS spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells.
Abstract translation: 本文描述的是荧光化合物和方法并且包含这些化合物。 本文公开的化合物是在紫外/可见光谱的红色部分中发荧光的卡吡泼因试剂，并提供明亮的荧光强度，均匀的细胞染色和活细胞内的良好保留以及对细胞的低毒性。
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