公开(公告)号：US20220399197A1

公开(公告)日：2022-12-15

申请号：US17755179

申请日：2020-11-10

Applicant: Thermo Fisher Scientific (Bremen) GmbH ,  Life Technologies Corporation ,  FEI Deutschland GmbH

Inventor： Alexander Makarov ,  Michael WARD ,  Rainer DAUM

IPC: H01J49/00 ,  H01J49/16 ,  G01N21/64

Abstract: Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device (110) includes an optical assembly (112), a sample stage (114), and a receiver (116). The optical assembly (112) is disposed in an inverted position below the sample stage (114) and the receiver (116) is positioned above the sample stage (112). The optical assembly enables imaging of a sample disposed on the sample stage (114). The optical assembly (112) also enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume (20) toward the receiver (116).

公开(公告)号：US20190086435A1

公开(公告)日：2019-03-21

申请号：US16106682

申请日：2018-08-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Glen DAVIS ,  John JACKSON ,  Gregory KADUCHAK ,  Wesley SMITH ,  Michael WARD

IPC: G01N35/10 ,  G01N15/14 ,  G01N35/00

Abstract: A sampling system is provided. The sampling system includes a housing. Mounted to the housing is a Hall effect sensor. A probe configured to contact a sample is inserted into the housing. The probe includes an elongated portion and a restorative spring inserted onto the elongated portion of the probe. The restorative spring provides sufficient restorative force to return the probe to a relaxed position. The Hall effect sensor is configured to sense a field strength generated by the proximity of the restorative spring of the probe in the extended position.

公开(公告)号：US20190033199A1

公开(公告)日：2019-01-31

申请号：US15990350

申请日：2018-05-25

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Gregory KADUCHAK ,  Wesley SMITH ,  Michael WARD

IPC: G01N15/14

CPC classification number: G01N15/1459 ,  G01N15/1404 ,  G01N15/1434 ,  G01N15/1456 ,  G01N2015/1438

Abstract: The present set of embodiments relate to a system, method, and apparatus for an optical configuration in a flow cytometer that allows for independent adjustment of focusing for each light source. Such systems, methods, and apparatuses require a final focusing element to be moved near the beginning of the optical train and for each optical element coming after the final focusing element to be configured to accommodate converging light beams while minimizing the introduction of aberrations into those beams.