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    APPARATUS FOR SEPARATING IONS
    1.
    发明申请
    APPARATUS FOR SEPARATING IONS 有权

    公开(公告)号：US20250069880A1

    公开(公告)日：2025-02-27

    申请号：US18810129

    申请日：2024-08-20

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Hamish Stewart

    IPC: H01J49/42

    Abstract: Ions are separated according to their mass-to-charge ratios. A separation region receives the ions, extending in a first direction and a second direction that is different to the first direction. An electrode arrangement confines the ions in the separation region. The electrode arrangement is configured to apply a time-varying potential in the separation region to cause the ions to move in the first direction and configured to apply a potential gradient in the separation region, the potential gradient opposing the time-10 varying potential, such that the ions are separated at different positions in the first direction according to the mass-to-charge ratios of the ions. A force is applied in the second direction to the ions to cause the ions to move in the second direction.

    FAILURE DETECTION OF SAMPLE INTRODUCTION SYSTEMS
    2.
    发明申请
    FAILURE DETECTION OF SAMPLE INTRODUCTION SYSTEMS 有权

    公开(公告)号：US20250069876A1

    公开(公告)日：2025-02-27

    申请号：US18722511

    申请日：2022-12-20

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Antonella Guzzonato ,  Mischa Jahn

    IPC: H01J49/04 ,  H01J49/10

    Abstract: A method of operating a sample introduction system of an inductively coupled plasma analytical instrument, the method comprising applying a trained classifier to instrument data, obtained from the analytical instrument, during operation of the analytical instrument, to detect whether the sample introduction system is operating in a normal state or in a failure state. The method further comprises activating an error procedure in the event that the sample introduction system is operating in a failure state. The instrument data comprises signal data obtained from an analytical measurement made by the analytical instrument. The trained classifier is trained using a training data set comprising instrument data corresponding to the normal state of the sample introduction system.

    HYBRID MASS SPECTROMETER AND DATA ACQUISITION METHODS
    3.
    发明申请
    HYBRID MASS SPECTROMETER AND DATA ACQUISITION METHODS 有权

    公开(公告)号：US20250046593A1

    公开(公告)日：2025-02-06

    申请号：US18441990

    申请日：2024-02-14

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Hamish STEWART ,  Christian HOCK ,  Philipp COCHEMS

    IPC: H01J49/00 ,  G01N30/02 ,  G01N30/72 ,  G01N30/86

    Abstract: A dual analyser mass spectrometer obtains MS1/MS2 scans of positive and negative ions by: operating an ion source and processing region at a first polarity; performing, by a first mass analyser (FMA) at the first polarity, MS1 or MS2 scan(s); switching polarity of the FMA to a second polarity; performing, by a second mass analyser (SMA) at the first polarity, MS1 or MS2 scan(s), wherein at least part of the MS1 or MS2 scan(s) performed by the SMA is performed while the FMA is switching polarity. Alternatively, the FMA may be operated at a first polarity and the SMA at a second polarity opposite to the first, and after initiating at least one MS1 scan and/or MS2 scan by the FMA, switching the polarity of the source and ion processing region to a second polarity and performing at least one MS1 scan and/or MS2 scan with the SMA.

    QUANTIFYING A SUBSTANCE PRESENT IN A SAMPLE
    4.
    发明申请
    QUANTIFYING A SUBSTANCE PRESENT IN A SAMPLE 有权

    公开(公告)号：US20250006479A1

    公开(公告)日：2025-01-02

    申请号：US18758170

    申请日：2024-06-28

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Pedro José Navarro Álvarez

    IPC: H01J49/00 ,  G01N27/623 ,  G01N30/72 ,  H01J49/40

    Abstract: A sample is separated by a first separator into constituent analytes over a time parameter. The constituent analytes are analysed by a mass spectrometer, which provides intensity measurements against mass-to-charge ratio for each constituent analyte. A relationship of the measured intensity at a mass-to-charge ratio over the time parameter for each constituent analyte defines a respective peak. A peak quality factor may be determined for each of the peaks and/or a common peak position in respect of the time parameter may be determined for at least some of the peaks. A specific range for a time parameter to be used for quantifying the substance may be based on the peak quality factor (or factors). Alternatively, a subset of the peaks may be selected for quantification of the substance, based on the determined peak quality factors and/or the determined common peak position.

    Inert non-adsorbing crimpable capillaries and devices for adjusting gas flow in isotope ratio analysis
    5.
    发明授权
    Inert non-adsorbing crimpable capillaries and devices for adjusting gas flow in isotope ratio analysis 有权

    公开(公告)号：US12159778B2

    公开(公告)日：2024-12-03

    申请号：US18473991

    申请日：2023-09-25

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Michael Krummen ,  Jens Radke ,  Johannes Schwieters ,  Nils Stöebener ,  Ronald Seedorf

    IPC: H01J49/04 ,  H01J49/00

    Abstract: A gas transfer system for transferring gas into an analytical instrument for isotope ratio analysis comprises a capillary for delivering sample and/or reference gas from a gas source, a first connector for connecting the capillary to the gas source, a second connector for connecting the capillary to the analytical instrument, a crimping device, wherein the internal surface of the capillary comprises a coating material to prevent or minimize adsorption of water to the surface. Also provided is a device for regulating gas flow in a gas inlet system of an analytical instrument, comprising a body member having an internal gas flow channel, and a clamping member for attachment to the body member such that when the clamping member is tightened onto the body member, the internal gas flow channel is adjustably and reversibly crimped, to adjust gas flow therethrough.

    METHODS OF MASS SPECTROMETRY, A MASS SPECTROMETER AND COMPUTER SOFTWARE
    6.
    发明申请
    METHODS OF MASS SPECTROMETRY, A MASS SPECTROMETER AND COMPUTER SOFTWARE 有权

    公开(公告)号：US20240393303A1

    公开(公告)日：2024-11-28

    申请号：US18672554

    申请日：2024-05-23

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Hamish Stewart ,  Alexander Makarov

    IPC: G01N30/86 ,  G01N30/02 ,  G01N30/72 ,  H01J49/40

    Abstract: A method of mass spectrometry is provided. The method comprises performing the following steps for each of a plurality of sub-ranges selected from an overall m/z range: accumulating in an ion store a sample of precursor ions to be analysed, the precursor ions having m/z values within the sub-range; accumulating in the ion store a sample of fragmented precursor ions to be analysed, the fragmented precursor ions being formed from fragmentation of precursor ions having m/z values within the sub-range; and simultaneously analysing the combined samples of the precursor ions and the fragmented precursor ions in a mass analyser.

    Interference suppression in mass spectrometer
    7.
    发明授权
    Interference suppression in mass spectrometer 有权

    公开(公告)号：US12148605B2

    公开(公告)日：2024-11-19

    申请号：US17441857

    申请日：2020-03-26

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Mikhail Belov ,  Lothar Rottman

    IPC: H01J49/10 ,  H01J49/00 ,  H01J49/42

    Abstract: A method of operating a collision cell (10) in a mass spectrometer is disclosed. The collision cell comprises an entrance aperture (116), an exit aperture (117) and electrodes (113, 114) for producing electric fields. The method comprises feeding ions in a forward axial direction (LD) through the entrance aperture into the collision cell, producing a first electric field to trap ions, and subsequently producing a second electric field to accelerate trapped ions in the forward axial direction. The method further comprises producing a gas flow (G1) which is, at least at the entrance aperture (116) of the collision cell, contrary to the forward axial direction (LD), so as to reduce the kinetic energy of ions in dependence on their collisional cross sections. A collision cell arranged for carrying out the method is also disclosed, as well as a mass spectrometer comprising such a collision cell.

    SYSTEM FOR SEPARATING AN ANALYTE FROM A SAMPLE
    9.
    发明公开
    SYSTEM FOR SEPARATING AN ANALYTE FROM A SAMPLE 审中-公开

    公开(公告)号：US20240302332A1

    公开(公告)日：2024-09-12

    申请号：US18575025

    申请日：2022-07-01

    Applicant: Thermo Fisher Scientific (Bremen) GmbH

    Inventor： Nils STÖBENER ,  Johannes SCHWIETERS ,  Andreas HILKERT

    IPC: G01N30/02 ,  G01N1/40 ,  G01N30/14 ,  G01N30/88

    CPC classification number: G01N30/02 ,  G01N1/40 ,  G01N30/14 ,  G01N30/88 ,  G01N2030/025 ,  G01N2030/8868

    Abstract: A system comprises a separator that separates an analyte from the sample, an analyser, downstream of the separator, configured to obtain measurements indicative of a quantity of the analyte in the sample. A bypass line provides a first fraction of the sample to the analyser for measurement without passing through the separator. A controller receives a measurement obtained by the analyser on the first fraction of the sample, the measurement indicating that the first fraction of the sample received via the bypass line comprises a threshold quantity of the analyte. Activation of the separator is based on the received measurement. A second fraction of the sample is provided to the analyser without passing through the bypass line such that the first fraction of the sample arrives at the analyser before the second fraction of the sample arrives at the separator.

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