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11.发明授权Spirotropane compounds and methods for the modulation of chemokine receptor activity 失效Spirotropane化合物和调节趋化因子受体活性的方法公开(公告)号：US07960403B2
公开(公告)日：2011-06-14
申请号：US11792581
申请日：2005-12-09
申请人： Laval Chan Chun Kong , Christophe Moinet , Marc Courchesne , Louis Vaillancourt , Charles Blais , Monica Bubenik
发明人： Laval Chan Chun Kong , Christophe Moinet , Marc Courchesne , Louis Vaillancourt , Charles Blais , Monica Bubenik
IPC分类号： A61K31/438 , C07D471/20
CPC分类号： C07D451/02
摘要： Compounds according to formula (I): wherein A, R1, R2 and R3 are defined as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
摘要翻译： 根据式（I）的化合物：其中A，R 1，R 2和R 3如本文所定义，其药学上可接受的盐，水合物和溶剂合物可用于调节CCR5趋化因子受体活性。
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12.发明申请Novel Spirotropane Compounds And Methods For The Modulation Of Chemokine Receptor Activity 失效新型Spirotropane化合物和调节趋化因子受体活性的方法公开(公告)号：US20090047238A1
公开(公告)日：2009-02-19
申请号：US11792577
申请日：2005-12-09
申请人： Laval Chan Chun Kong , Christophe Moinet , Marc Courchesne , Louis Vaillancourt , Monica Bubenik
发明人： Laval Chan Chun Kong , Christophe Moinet , Marc Courchesne , Louis Vaillancourt , Monica Bubenik
IPC分类号： A61K31/438 , C07D401/14 , A61K38/20 , A61P31/18
CPC分类号： C07D451/02
摘要： Compounds according to formula, (I): wherein A, R1 and R2 are as defined herein, and the pharmaceutically acceptable salts, hydrates and solvates thereof are useful for the modulation of CCR5 chemokine receptor activity.
摘要翻译： 根据式（I）的化合物：其中A，R 1和R 2如本文所定义，并且其药学上可接受的盐，水合物和溶剂合物可用于调节CCR5趋化因子受体活性。
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公开(公告)号：US08269026B2
公开(公告)日：2012-09-18
申请号：US12830293
申请日：2010-07-03
申请人： Christophe Moinet , Liliane Halab , Nathalie Turcotte , Monica Bubenik , Marc Courchesne , Carl Poisson , Oswy Z. Pereira , Paul Nguyen-Ba , Bingcan Liu , Nathalie Chauret , Caroline Cadilhac , Laval Chan Chun Kong
发明人： Christophe Moinet , Liliane Halab , Nathalie Turcotte , Monica Bubenik , Marc Courchesne , Carl Poisson , Oswy Z. Pereira , Paul Nguyen-Ba , Bingcan Liu , Nathalie Chauret , Caroline Cadilhac , Laval Chan Chun Kong
IPC分类号： C07J53/00
CPC分类号： C07J63/008
摘要： The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
摘要翻译： 本发明涉及式（I）的21-酮三萜化合物：其中R 1，X和Y如本文所定义，及其药学上可接受的盐和溶剂化物。 这些化合物显示出显着的抗HIV活性。 因此，本发明还涉及通过向需要这种治疗的受试者施用治疗有效量的式（I）化合物或其药学上可接受的盐或溶剂合物来预防或治疗HIV感染的方法。
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公开(公告)号：US20110077227A1
公开(公告)日：2011-03-31
申请号：US12830293
申请日：2010-07-03
申请人： Christophe Moinet , Liliane Halab , Nathalie Turcotte , Monica Bubenik , Marc Courchesne , Carl Poisson , Oswy Z. Pereira , Paul Nguyen-Ba , Bingcan Liu , Nathalie Chauret , Caroline Cadilhac , Laval Chan Chun Kong
发明人： Christophe Moinet , Liliane Halab , Nathalie Turcotte , Monica Bubenik , Marc Courchesne , Carl Poisson , Oswy Z. Pereira , Paul Nguyen-Ba , Bingcan Liu , Nathalie Chauret , Caroline Cadilhac , Laval Chan Chun Kong
IPC分类号： C07J53/00 , A61K31/565 , A61K31/58 , A61K31/566 , A61P31/18
CPC分类号： C07J63/008
摘要： The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
摘要翻译： 本发明涉及式（I）的21-酮三萜化合物：其中R 1，X和Y如本文所定义，及其药学上可接受的盐和溶剂合物。 这些化合物显示出显着的抗HIV活性。 因此，本发明还涉及通过向需要这种治疗的受试者施用治疗有效量的式（I）化合物或其药学上可接受的盐或溶剂合物来预防或治疗HIV感染的方法。
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15.发明申请Spiro compounds and methods for the modulation of chemokine receptor activity 失效Spiro化合物和调节趋化因子受体活性的方法公开(公告)号：US20050070563A1
公开(公告)日：2005-03-31
申请号：US10937880
申请日：2004-09-10
IPC分类号： C07D471/10 , A61K31/4747 , C07D487/10
CPC分类号： C07D471/10
摘要： Compounds of formula I wherein X, Y, Z, W, R1 and R2 as defined herein, or pharmaceutically acceptable salts, hydrates or solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
摘要翻译： 其中本文定义的X，Y，Z，W，R 1和R 2或其药学上可接受的盐，水合物或溶剂合物的式I化合物可用于调节CCR5趋化因子受体活性。
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16.发明申请SPIROHYDANTOIN COMPOUNDS AND METHODS FOR THE MODULATION OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开螺蛋白激素化合物和调节感受器活性的方法公开(公告)号：US20100286183A1
公开(公告)日：2010-11-11
申请号：US12756367
申请日：2010-04-08
IPC分类号： A61K31/438 , A61P11/06 , A61P19/02 , A61P9/10
CPC分类号： C07D471/10
摘要： Novel compounds represented by formula (I): wherein R1, R2, R3 and R4 are as defined herein, and pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
摘要翻译： 由式（I）表示的新型化合物：其中R 1，R 2，R 3和R 4如本文所定义，及其药学上可接受的盐，水合物和溶剂化物，可用于调节CCR5趋化因子受体活性。
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17.发明授权Spirohydantoin compounds and methods for the modulation of chemokine receptor activity 失效螺乙内酰脲化合物和调节趋化因子受体活性的方法公开(公告)号：US07709642B2
公开(公告)日：2010-05-04
申请号：US11159406
申请日：2005-06-23
IPC分类号： A01N43/42 , A61K31/44 , C07D401/00 , C07D451/00 , C07D453/00 , C07D455/00 , C07D471/00
CPC分类号： C07D471/10
摘要： Novel compounds represented by formula (I): wherein R1, R2, R3 and R4 are as defined herein, and pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
摘要翻译： 由式（I）表示的新型化合物：其中R 1，R 2，R 3和R 4如本文所定义，及其药学上可接受的盐，水合物和溶剂化物，可用于调节CCR5趋化因子受体活性。
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公开(公告)号：US20110077251A1
公开(公告)日：2011-03-31
申请号：US12856848
申请日：2010-08-16
申请人： Christophe Moinet , Bingcan Liu , Liliane Halab , Nathalie Turcotte , Real Denis , Carl Poisson , Paul Nguyen-Ba , Monica Bubenik , Laval Chan Chun Kong
发明人： Christophe Moinet , Bingcan Liu , Liliane Halab , Nathalie Turcotte , Real Denis , Carl Poisson , Paul Nguyen-Ba , Monica Bubenik , Laval Chan Chun Kong
IPC分类号： A61K31/5375 , C07C271/24 , C07C69/34 , C07D295/195 , C07C69/74 , C07D211/60 , C07D211/32 , C07D271/113 , C07D277/46 , C07D309/06 , C07D213/75 , C07D207/04 , C07D231/14 , A61K31/215 , A61K31/495 , A61K31/4453 , A61K31/4245 , A61K31/426 , A61K31/351 , A61K31/4409 , A61K31/40 , A61K31/415 , A61P31/18
摘要： The invention relates to 17β lupane derivatives of formula (I): wherein R1 and X are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infection by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
摘要翻译： 本发明涉及17＆bgr; 式（I）的十二烷衍生物：其中R 1和X如本文所定义，及其药学上可接受的盐和溶剂化物。 这些化合物显示出显着的抗HIV活性。 因此，本发明还涉及通过向需要这种治疗的受试者施用治疗有效量的式（I）化合物或其药学上可接受的盐或溶剂合物来预防或治疗HIV感染的方法。
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19.发明授权公开(公告)号：US07220765B2
公开(公告)日：2007-05-22
申请号：US10615481
申请日：2003-07-08
IPC分类号： A61K31/426 , C07D277/18
CPC分类号： C07D277/38 , C07D277/42 , C07D417/04 , C07D417/06 , C07D417/14
摘要： The present invention is drawn to compounds of the formula in racemic and enantiomeric form or all combinations of these forms wherein the various substituents are as defined in the application which compounds have a good affinity for certain subtypes of somatostatin receptors and have useful pharmacological properties.
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20.发明申请Spirohydantoin compounds and methods for the modulation of chemokine receptor activity 失效螺乙内酰脲化合物和调节趋化因子受体活性的方法公开(公告)号：US20060014769A1
公开(公告)日：2006-01-19
申请号：US11159406
申请日：2005-06-23
IPC分类号： A61K31/4747 , C07D487/10
CPC分类号： C07D471/10
摘要： Novel compounds represented by formula (I): wherein R1, R2, R3 and R4 are as defined herein, and pharmaceutically acceptable salts, hydrates and solvates thereof, are useful for the modulation of CCR5 chemokine receptor activity.
摘要翻译： 由式（I）表示的新型化合物：其中R 1，R 2，R 3和R 4均为 如本文所定义，及其药学上可接受的盐，水合物和溶剂化物，可用于调节CCR5趋化因子受体活性。
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