公开(公告)号：US20070099181A1

公开(公告)日：2007-05-03

申请号：US11474609

申请日：2006-06-26

申请人： Li Wang ,  Lorne Babiuk ,  Andrew Potter ,  Philip Willson

发明人： Li Wang ,  Lorne Babiuk ,  Andrew Potter ,  Philip Willson

IPC分类号： C12Q1/70 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/86 ,  C07K14/01

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/552 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/10022 ,  C12N2750/10043 ,  C12Q1/701

摘要： The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.

摘要翻译： 新型PCVII病毒基因组的克隆描述为源自PCVII基因组的蛋白质的表达。 这些蛋白质可用于预防和治疗PCVII感染的疫苗组合物中，以及用于确定脊椎动物受试者中PCVII感染存在的诊断方法。 衍生自病毒基因组的多核苷酸可用作诊断引物和探针。

公开(公告)号：US20060286642A1

公开(公告)日：2006-12-21

申请号：US11485240

申请日：2006-07-12

申请人： Deborah Haines ,  Gordon Allan ,  John Ellis ,  Brian Meehan ,  Edward Clark ,  Lori Hassard ,  John Harding ,  Catherine Charreyre ,  Gilles Chappuis ,  Francis McNeilly ,  Li Wang ,  Lorne Babiuk ,  Andrew Potter ,  Philip Willson

发明人： Deborah Haines ,  Gordon Allan ,  John Ellis ,  Brian Meehan ,  Edward Clark ,  Lori Hassard ,  John Harding ,  Catherine Charreyre ,  Gilles Chappuis ,  Francis McNeilly ,  Li Wang ,  Lorne Babiuk ,  Andrew Potter ,  Philip Willson

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K48/00 ,  A61K2039/51 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/10022 ,  C12N2750/10034 ,  C12N2750/10043 ,  C12Q1/701

摘要： The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.

公开(公告)号：US20090048893A1

公开(公告)日：2009-02-19

申请号：US12120423

申请日：2008-05-14

申请人： Li Wang ,  Hai Bo Yu ,  Feng Li Wang ,  John Turek

发明人： Li Wang ,  Hai Bo Yu ,  Feng Li Wang ,  John Turek

IPC分类号： G06Q10/00

CPC分类号： G06Q10/109 ,  G06Q10/1093

摘要： A method for calendaring an activity based on roles, including the steps of acquiring a request for calendaring the activity for a plurality of roles invited to attend the activity; acquiring data on existing activities which have been calendared for all the specific individuals in the plurality of roles invited to attend the activity; and determining the time interval for holding the activity based on the data on existing activities which have been calendared for all the specific individuals in the plurality of roles invited to attend the activity and the request for calendaring the activity.

摘要翻译： 一种用于基于角色对活动进行日程安排的方法，包括获取对被邀请参加该活动的多个角色的活动的日历请求的步骤; 获取被邀请参加活动的多个角色中针对所有具体个人进行的已登录活动的数据; 以及基于被邀请参加活动的多个角色中的所有特定个人已经被日历的已有活动的数据以及对活动进行日程安排的请求，确定保持活动的时间间隔。

公开(公告)号：US11767534B2

公开(公告)日：2023-09-26

申请号：US14115608

申请日：2012-05-04

申请人： Tarjei Mikkelsen ,  Andreas Gnirke ,  Alexandre Melnikov ,  Eric S. Lander ,  Li Wang ,  Xiaolan Zhang

发明人： Tarjei Mikkelsen ,  Andreas Gnirke ,  Alexandre Melnikov ,  Eric S. Lander ,  Li Wang ,  Xiaolan Zhang

IPC分类号： C12N15/63 ,  C12N15/10

CPC分类号： C12N15/63 ,  C12N15/1086 ,  C12N15/1086 ,  C12Q2563/179 ,  C12Q2525/155

摘要： The invention provides methods for determining the activity of a plurality of nucleic acid regulatory elements. These methods may facilitate, e.g., the systematic reverse engineering, and optimization of mammalian cis-regulatory elements at high resolution and at a large scale. The method may include integration of multiplexed DNA synthesis and sequencing technologies to generate and quantify the transcriptional regulatory activity of e.g., thousands of arbitrary DNA sequences in parallel in cell-based as says (e.g., mammalian cell based assays).

公开(公告)号：USD968323S1

公开(公告)日：2022-11-01

申请号：US29790728

申请日：2021-12-13

申请人： Li Wang

设计人： Li Wang

公开(公告)号：US11123426B2

公开(公告)日：2021-09-21

申请号：US15317552

申请日：2015-06-11

申请人： Kathy A. Green ,  Li Wang ,  Randolph J. Noelle ,  William R. Green

发明人： Kathy A. Green ,  Li Wang ,  Randolph J. Noelle ,  William R. Green

IPC分类号： A61K31/198 ,  A61K39/395 ,  C07K16/28 ,  A61K45/06

摘要： Methods for alleviating the suppression of humoral immunity by myeloid-dependent suppressor cells (MDSCs) are provided which include the administration of a VISTA antagonist and an iNOS/NO inhibitor in a subject in need thereof, e.g., subjects with cancer or infectious disease wherein VISTA is aberrantly expressed. This combination has been discovered to elicit a synergistic or additive effect on alleviating suppression of humoral immunity by VISTA which is elicited by MDSCs.

公开(公告)号：US10704031B2

公开(公告)日：2020-07-07

申请号：US16198773

申请日：2018-11-22

申请人： Jing Wu ,  Li Wang

发明人： Jing Wu ,  Li Wang

IPC分类号： C12N9/12 ,  C12N15/52 ,  C12N15/63 ,  C12P19/34

摘要： Disclosed are Dpo4 DNA polymerase mutants with increased DNA synthesis processivity. The mutant enzymes, Dpo4 A181D and Dpo4 E63K, are constructed based on the wild-type Dpo4 derived from Sulfolobus solfataricus to obtain Dpo4DNA polymerase mutants with increased DNA processivity. The extension length of Dpo4 A181D and Dpo4 E63K are respectively increased by 25% and 18.8% than that of the wild-type Dpo4. The fidelity of Dpo4 A181D and wild-type Dpo4 are similar, and the fidelity of Dpo4 E63K is increased from that of the wild-type Dpo4. In summary, the mutants Dpo4 A181D and Dpo4 E63K obtained by the present invention have increased processivity compared to that of the wild-type Dpo4 DNA polymerase.

公开(公告)号：US20190086128A1

公开(公告)日：2019-03-21

申请号：US16081007

申请日：2017-02-28

申请人： Xiuping Su ,  Li Wang ,  Johnson Controls Technology Company

发明人： Xiuping Su ,  Li Wang

IPC分类号： F25B39/00 ,  F25B1/06

摘要： Embodiments of the present disclosure are directed to a heat exchange device that includes a condenser configured to receive a refrigerant, an evaporator having an evaporation tube bundle, a throttling device configured to receive a first portion of the refrigerant from the condenser and to expand the first portion of the refrigerant before directing the first portion to the evaporator, and an ejector having a high pressure conduit, a low pressure conduit, and an outlet conduit, the ejector is configured to receive the first portion from the throttling device or a second portion of the refrigerant from the condenser via the high pressure conduit, receive a third portion of the refrigerant from the evaporator via the low pressure conduit, mix the first portion or the second portion with the third portion to form a mixed refrigerant, and direct the mixed refrigerant to the evaporator via the outlet conduit.

公开(公告)号：US09538922B2

公开(公告)日：2017-01-10

申请号：US12609700

申请日：2009-10-30

申请人： Li Wang

发明人： Li Wang

IPC分类号： A61B5/02 ,  A61B5/024 ,  A61B5/0245 ,  A61B5/0452 ,  A61N1/37 ,  A61N1/372 ,  A61B5/00 ,  A61N1/362

CPC分类号： A61B5/024 ,  A61B5/0245 ,  A61B5/0452 ,  A61B5/7285 ,  A61N1/3627 ,  A61N1/3702 ,  A61N1/37258

摘要： Aspects of this disclosure describe measuring intervals within a cardiac cycle to, for example, determine whether a patient is a candidate for cardiac therapy initiation or modification. The intervals may be measured in response to a trigger identifying a physiological event. The intervals and an identification of the physiological event may be stored. A physician or clinician may determine whether the patient is a candidate for cardiac therapy modification based on the measured intervals.

摘要翻译： 本公开的方面描述了心脏周期内的测量间隔，以例如确定患者是否是心脏治疗开始或修改的候选者。 可以响应于识别生理事件的触发来测量间隔。 可以存储生理事件的间隔和识别。 医生或临床医生可以基于测量的间隔来确定患者是否是心脏修复的候选者。

公开(公告)号：US09362016B2

公开(公告)日：2016-06-07

申请号：US13553931

申请日：2012-07-20

申请人： Jian-Gang Li ,  Xiang-Ming He ,  Jian-Jun Li ,  Jian Gao ,  Li Wang

发明人： Jian-Gang Li ,  Xiang-Ming He ,  Jian-Jun Li ,  Jian Gao ,  Li Wang

IPC分类号： H01B1/08 ,  H01M4/00 ,  C01G53/00 ,  H01M4/04 ,  H01M4/1391 ,  H01M4/36 ,  H01M4/505 ,  H01M4/62

CPC分类号： H01B1/08 ,  C01G53/54 ,  C01P2002/72 ,  C01P2004/03 ,  C01P2004/80 ,  C01P2006/40 ,  H01M4/0471 ,  H01M4/1391 ,  H01M4/366 ,  H01M4/505 ,  H01M4/62 ,  Y02E60/122 ,  Y02P70/54

摘要： A cathode active material of a lithium ion battery includes a number of LiNi0.5Mn1.5O4 particles and an AlF3 layer coated on a surface of the LiNi0.5Mn1.5O4 particles. A method for making the cathode active material is provided. In the method, a number of LiNi0.5Mn1.5O4 particles are provided. The LiNi0.5Mn1.5O4 particles are added to a trivalent aluminum source solution to form a solid-liquid mixture. A fluorine source solution is put into the solid-liquid mixture to react and form an AlF3 layer coated on the surface of the LiNi0.5Mn1.5O4 particles. The coated LiNi0.5Mn1.5O4 particles are heat treated to form the cathode active material. A lithium ion battery including the cathode active material is also provided.

摘要翻译： 锂离子电池的正极活性物质包括多个LiNi 0.5 Mn 1.5 O 4颗粒和涂覆在LiNi0.5Mn1.5O4颗粒表面上的AlF 3层。 提供了制造阴极活性材料的方法。 在该方法中，提供了许多LiNi 0.5 Mn 1.5 O 4颗粒。 将LiNi0.5Mn1.5O4颗粒加入到三价铝源溶液中以形成固液混合物。 将氟源溶液放入固液混合物中反应并形成涂覆在LiNi0.5Mn1.5O4颗粒表面上的AlF3层。 涂覆的LiNi0.5Mn1.5O4颗粒被热处理以形成阴极活性材料。 还提供了包括阴极活性材料的锂离子电池。