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    Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs
    13.
    发明申请
    Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs 有权
    辐射敏感性纳米粒子和化疗药物辐射敏感性共聚物载体的制备方法

    公开(公告)号：US20160113884A1

    公开(公告)日：2016-04-28

    申请号：US14522583

    申请日：2014-10-24

    申请人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

    发明人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

    IPC分类号： A61K9/51 ,  A61K31/704

    CPC分类号： A61K9/5146 ,  A61K9/5192 ,  A61K31/704

    摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

    摘要翻译： 用于涂覆辐射纳米颗粒和/或化疗药物的辐射敏感性共聚物载体的制备方法包括通过二硒化物嵌段共聚物和DSPE-PEG-生物标志物形成纳米球，以涂覆可以从开放的纳米球释放的化学药物和/或辐射纳米颗粒， 在质子治疗期间质子穿透组织。 质子治疗的治疗效果通过使用从开放的纳米球释放的辐射纳米颗粒产生核裂变以释放电子以释放肿瘤的肿瘤细胞的质子和从打开的纳米球释放的化疗药物在组织间分布的两种方式得到增强 杀死肿瘤的癌细胞。

    Method of fabricating indium-111 radioactive isotope
    15.
    发明授权
    Method of fabricating indium-111 radioactive isotope 有权
    制造铟-111放射性同位素的方法

    公开(公告)号：US08647407B2

    公开(公告)日：2014-02-11

    申请号：US13352550

    申请日：2012-01-18

    申请人： Wuu-Jyh Lin ,  Chien-Hsin Lu ,  Jenn-Tzong Chen ,  Sun-Rong Hwang ,  Ying-Chieh Wang

    发明人： Wuu-Jyh Lin ,  Chien-Hsin Lu ,  Jenn-Tzong Chen ,  Sun-Rong Hwang ,  Ying-Chieh Wang

    IPC分类号： C22B58/00

    CPC分类号： C22B58/00 ,  G21G1/001 ,  G21G2001/0057

    摘要： The present invention provides a method for fabricating an indium(In)-111 radioactive isotope. A target of cadmium(Cd)-112 is processed through steps of dissolving with heat, absorbing, washing, desorbing and drying for obtaining the In-111 radioactive isotope. Thus, chemical separation is coordinated with the target for fabricating the In-111 radioactive isotope with high efficiency and low cost for production procedure.

    摘要翻译： 本发明提供一种制造铟（In）-111放射性同位素的方法。 通过加热，吸收，洗涤，解吸和干燥的步骤来处理镉（Cd）-112的靶子，以获得In-111放射性同位素。 因此，化学分离与用于制造In-111放射性同位素的靶相配合，生产过程效率高，成本低。

    Method for Making Radioactive Isotopic Gallium-67
    16.
    发明申请
    Method for Making Radioactive Isotopic Gallium-67 审中-公开
    放射性同位素镓67的制备方法

    公开(公告)号：US20110214995A1

    公开(公告)日：2011-09-08

    申请号：US12718826

    申请日：2010-03-05

    申请人： Sun-Rong Huang ,  Ying-Ming Tsai ,  Jainn-Hsin Lu ,  Jenn-Tzong Chen ,  Wuu-Jyh Lin

    发明人： Sun-Rong Huang ,  Ying-Ming Tsai ,  Jainn-Hsin Lu ,  Jenn-Tzong Chen ,  Wuu-Jyh Lin

    IPC分类号： C25C1/22

    CPC分类号： C25C1/22 ,  Y02P10/234

    摘要： Disclosed is a method for making carrier-free radioactive isotopic gallium-67. Stable isotopic zinc-68 is turned into zinc-68 solid target by disposition or electroplating. Then, the zinc-68 solid target is subjected to a proton beam. A cyclotron is used to provide irradiation from 15 to 40 MeV. After the irradiation, the zinc-68 solid target is dissolved in concentrated acid and turned into solution that contains zinc-65, zinc-68, gallium-67 and gallium-68. High concentrated hydrochloric acid and resin are added into the solution for exchange of ions. Zinc-68 liquid and gallium-67 liquid are filtered and separated from the solution. Thus, pure gallium-67 liquid is produced. With a vaporizer, the gallium-67 liquid is vaporized and turned into radioactive isotopic gallium-67.

    摘要翻译： 公开了一种制造无载体放射性同位素镓-67的方法。 通过配置或电镀，稳定的同位素锌-68变成锌-68固体靶。 然后，对锌-68固体靶进行质子束。 回旋加速器用于提供15至40MeV的照射。 照射后，将锌-68固体靶溶解在浓酸中，变成含有锌-65，锌-68，镓-67和镓-68的溶液。 将高浓度的盐酸和树脂加入溶液中以交换离子。 将锌-68液体和镓-67液体从溶液中过滤并分离。 因此，产生纯的镓-67液体。 使用蒸发器，镓-67液体被蒸发并变成放射性同位素镓-67。

    Method of Fabricating Indium-111 Radioactive Isotope
    17.
    发明申请
    Method of Fabricating Indium-111 Radioactive Isotope 有权
    制备铟-111放射性同位素的方法

    公开(公告)号：US20130104697A1

    公开(公告)日：2013-05-02

    申请号：US13352550

    申请日：2012-01-18

    申请人： Wuu-Jyh Lin ,  Chien-Hsin Lu ,  Jenn-Tzong Chen ,  Sun-Rong Hwang ,  Ying-Chieh Wang

    发明人： Wuu-Jyh Lin ,  Chien-Hsin Lu ,  Jenn-Tzong Chen ,  Sun-Rong Hwang ,  Ying-Chieh Wang

    IPC分类号： C22B58/00

    CPC分类号： C22B58/00 ,  G21G1/001 ,  G21G2001/0057

    摘要： The present invention provides a method for fabricating an indium(In)-111 radioactive isotope. A target of cadmium(Cd)-112 is processed through steps of dissolving with heat, absorbing, washing, desorbing and drying for obtaining the In-111 radioactive isotope. Thus, chemical separation is coordinated with the target for fabricating the In-111 radioactive isotope with high efficiency and low cost for production procedure.

    摘要翻译： 本发明提供一种制造铟（In）-111放射性同位素的方法。 通过加热，吸收，洗涤，解吸和干燥的步骤来处理镉（Cd）-112的靶子，以获得In-111放射性同位素。 因此，化学分离与用于制造In-111放射性同位素的靶相配合，生产过程效率高，成本低。

    Device for separating out radioisotope thallium-201
    19.
    发明授权
    Device for separating out radioisotope thallium-201 有权
    用于分离放射性同位素铊-201的装置

    公开(公告)号：US08157998B2

    公开(公告)日：2012-04-17

    申请号：US12621979

    申请日：2009-11-19

    申请人： Wuu-Jyh Lin ,  Jenn-Tzong Chen ,  Sun-Rong Huang ,  Ying-Ming Tsai ,  Jainn-Hsin Lu

    发明人： Wuu-Jyh Lin ,  Jenn-Tzong Chen ,  Sun-Rong Huang ,  Ying-Ming Tsai ,  Jainn-Hsin Lu

    IPC分类号： B01D59/26

    CPC分类号： C01G15/00 ,  B01D61/14 ,  B01D61/145 ,  B01D61/147 ,  B01D61/16 ,  B01D2311/04 ,  B01D2311/16 ,  B01D2311/2623 ,  B01D2311/2673 ,  C01P2006/88

    摘要： Disclosed is a device for separating radioisotope thallium-201. The device includes an evaporation unit for a solution vial, a first glass vial connected to a first valve and a second valve, an ion exchange column connected to a third valve, a second glass vial connected to a fourth valve and a fifth valve, a collection vial for receiving solution from the fifth valve, a product vial with a membrane filter and a vacuum unit connected to the first valve, the fourth valve and a sixth valve. This device can separate out high-concentration thallium-201 solution from which radioisotope thallium-201 can be obtained.

    摘要翻译： 公开了一种用于分离放射性同位素铊-201的装置。 该装置包括用于溶液小瓶的蒸发单元，连接到第一阀和第二阀的第一玻璃小瓶，连接到第三阀的离子交换柱，连接到第四阀和第五阀的第二玻璃小瓶， 用于从第五阀接收溶液的收集瓶，具有膜过滤器的产品小瓶和连接到第一阀，第四阀和第六阀的真空单元。 该装置可以分离出可从其获得放射性同位素铊-201的高浓度铊-201溶液。

    Method of recycling Cd-112 isotope
    20.
    发明授权
    Method of recycling Cd-112 isotope 有权

    公开(公告)号：US08043584B2

    公开(公告)日：2011-10-25

    申请号：US11812984

    申请日：2007-06-22

    申请人： Wuu-Jyh Lin ,  Song-Un Tang

    发明人： Wuu-Jyh Lin ,  Song-Un Tang

    IPC分类号： C22B17/00

    CPC分类号： C01G11/00

    摘要： Cd-112 isotope is recycled from a Cd-112 chemical separated solution or a remainder of an electroplating solution having a Cd-112 target. The present invention recycles Cd-112 isotope with a low cost, a high purity and a high recycle rate. The recycled Cd-112 isotope can be easily stored. And, the Cd-112 isotope can be used as an imaging agent in nuclear medicine.