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    Method for F-18 FLT Synthesis
    1.
    发明申请
    Method for F-18 FLT Synthesis 有权
    F-18 FLT合成方法

    公开(公告)号：US20130072672A1

    公开(公告)日：2013-03-21

    申请号：US13237067

    申请日：2011-09-20

    申请人： Li-Yuan Huang ,  Yen-Hung Tu ,  Wen-Chin Su ,  Jenn-Tzong Chen ,  Ting-Shien Duh ,  Wuu-Jyh Lin

    发明人： Li-Yuan Huang ,  Yen-Hung Tu ,  Wen-Chin Su ,  Jenn-Tzong Chen ,  Ting-Shien Duh ,  Wuu-Jyh Lin

    IPC分类号： C07H21/00

    CPC分类号： C07H19/06

    摘要： The present invention establishes a fast and simple [F-18] FLT synthesis process. Solid extraction units are used for purification to achieve an equally high and constant radiochemical yield and purity in a short period of time. By using a separation method, the impurities are reduced successfully while the total synthesis time is shortened. The radiochemical purity and the corrected radiochemical yield are both high.

    摘要翻译： 本发明建立了快速简单的[F-18] FLT合成方法。 固体提取单元用于纯化，以在短时间内实现同样高且恒定的放射化学产率和纯度。 通过使用分离方法，在总合成时间缩短的同时成功地降低杂质。 放射化学纯度和校正放射化学产率都很高。

    Method used to yield irradiation product with minimal impurity for solid target for gallium (Ga)-68/germanium (Ge)-68 generator
    2.
    发明授权
    Method used to yield irradiation product with minimal impurity for solid target for gallium (Ga)-68/germanium (Ge)-68 generator 有权
    用于为镓（Ga）-68 /锗（Ge）-68发生器的固体靶产生最小杂质的辐射产物的方法

    公开(公告)号：US08239159B2

    公开(公告)日：2012-08-07

    申请号：US12569908

    申请日：2009-09-30

    申请人： Ming-Hsin Li ,  Ting Shien Duh ,  Wuu-Jyn Lin

    发明人： Ming-Hsin Li ,  Ting Shien Duh ,  Wuu-Jyn Lin

    IPC分类号： G06F15/00

    CPC分类号： G21G1/10 ,  G21G2001/0094

    摘要： A method used to yield irradiation product with minimal impurity for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator mainly consists of the procedures: first calculate the thickness d for the electroplated gallium (Ga)-69 on the solid target; and then through a graph of decay curves including 69Ga(p, 2n) 68Ge target thickness and incident energy with 5 different incident energy doses, derive the corresponding irradiation energy dose Yi for each group after decay; and through the graph including 69Ga(p,2n)68Ge incident energy and reaction cross-sectional area, derive the nuclear reaction cross-sectional area for each group for germanium(Ge)-68, gallium (Ga)-68, zinc (Zn)-65 and figure out the mean reaction area (MRA) from the reaction cross-sectional area of each group; and select the maximum germanium(Ge)-68 MRA value and the minimum gallium (Ga)-68 and zinc (Zn)-65 MRA values; and generate the required default irradiation energy for the MRA of each group.

    摘要翻译： 用于产生镓（Ga）-68 /锗（Ge）-68发生器的固体靶的杂质最小的辐射产物的方法主要包括以下步骤：首先计算电镀镓（Ga）-69的厚度d 坚实的目标; 然后通过包括69 Ga（p，2n）68Ge目标厚度和入射能量与5个不同入射能量剂量的衰减曲线图，得出每个组在衰变后的相应的照射能量剂量Yi; 通过包括69Ga（p，2n）68Ge入射能和反应截面积的图，得出锗（Ge）-68，镓（Ga）-68，锌（Zn）的每个组的核反应截面积 ）-65，计算每组反应截面积的平均反应面积（MRA）; 并选择最大锗（Ge）-68 MRA值和最小镓（Ga）-68和锌（Zn）-65 MRA值; 并为每组的MRA产生所需的默认照射能量。

    Method to produce a high-purity Zr-89 through physical irradiation and measurement thereof
    3.
    发明申请
    Method to produce a high-purity Zr-89 through physical irradiation and measurement thereof 审中-公开

    公开(公告)号：US20170110211A1

    公开(公告)日：2017-04-20

    申请号：US14882456

    申请日：2015-10-14

    申请人： Ming-Hsin LI ,  Ting-Shien DUH ,  Wuu-Jyh LIN ,  Han-Hsiang CHU

    发明人： Ming-Hsin LI ,  Ting-Shien DUH ,  Wuu-Jyh LIN ,  Han-Hsiang CHU

    IPC分类号： G21G1/00 ,  G21G1/10

    CPC分类号： G21G1/001 ,  G21G1/10 ,  G21G2001/0094

    摘要： A method to produce a high-purity Zr-89 on a solid target through physical irradiation and measurement by selecting a target Barn value of the cross-sectional area of nuclear reaction, drawing a horizontal line to intersect at two points on the function diagram curve and drawing a vertical line downward from each of the two points intersecting at X-axis to obtain incident energy values at the two intersecting points on the X-axis, and followed by plotting an attenuation function diagram curve of penetration depth versus incident energy of Y-89(p,n)Zr-89, selecting an attenuation function diagram curve and a minimum attenuation position of the selected attenuation function diagram curve in correspondence to the incident energy in the interval of incident energy absorption range to obtain an optimal plating thickness value on the solid target.

    Process parameter assessment method for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator
    6.
    发明申请
    Process parameter assessment method for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator 有权
    镓（Ga）-68 /锗（Ge）-68发生器的固体靶的工艺参数评估方法

    公开(公告)号：US20110077894A1

    公开(公告)日：2011-03-31

    申请号：US12569908

    申请日：2009-09-30

    申请人： Ming-Hsin Li ,  Ting Shien Duh ,  Wuu-Jyn Lin

    发明人： Ming-Hsin Li ,  Ting Shien Duh ,  Wuu-Jyn Lin

    IPC分类号： G06F15/00

    CPC分类号： G21G1/10 ,  G21G2001/0094

    摘要： A process parameter assessment method for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator mainly consists of the procedures: first calculate the thickness d for the electroplated gallium (Ga)-69 on the solid target; and then through a graph of decay curves comprising 69Ga(p, 2n) 68Ge target thickness and incident energy with 5 different incident energy doses (30, 26, 25, 24, 23 MeV), based on electroplating thickness d, derive the corresponding irradiation energy dose Yi for each group after decay; and through the graph comprising 69Ga(p, 2n) 68Ge incident energy and reaction cross-sectional area (containing corrected function graph of incident energy for germanium-68, gallium-68, or zinc-65 and reaction cross-sectional area), based on the defined range by irradiation energy dose Xi and the corresponding irradiation energy dose Yi, derive the nuclear reaction cross-sectional area for each group for germanium (Ge)-68, gallium (Ga)-68, zinc (Zn)-65 and figure out the mean reaction area (MRA) from the reaction cross-sectional area of each group; and select the maximum germanium (Ge)-68 MRA value and the minimum gallium (Ga)-68 and zinc (Zn)-65 MRA values; and generate the required default irradiation energy for the MRA of each group as the optimal reaction energy.

    摘要翻译： 用于镓（Ga）-68 /锗（Ge）-68发生器的固体靶的工艺参数评估方法主要包括以下步骤：首先计算固体靶上电镀镓（Ga）-69的厚度d; 然后通过基于电镀厚度d的包括69Ga（p，2n）68Ge目标厚度和具有5种不同入射能量剂量（30,26,25,24,23MeV）的入射能）的衰减曲线图导出相应的辐射 能量Yi每组后衰变; 并且通过包括69Ga（p，2n）68Ge入射能和反应截面积（包含用于锗-68，镓-68或锌-65的入射能量的校正函数图和反应横截面积）的图，基于 通过照射能量剂量Xi和相应的照射能量剂量Yi定义的范围，得出锗（Ge）-68，镓（Ga）-68，锌（Zn）-65和 从每组的反应横截面积中求出平均反应面积（MRA）; 并选择最大锗（Ge）-68 MRA值和最小镓（Ga）-68和锌（Zn）-65 MRA值; 并为每组的MRA产生所需的默认照射能量作为最佳反应能量。

    Liquid isotope delivery system
    7.
    发明申请
    Liquid isotope delivery system 审中-公开
    液体同位素输送系统

    公开(公告)号：US20100243082A1

    公开(公告)日：2010-09-30

    申请号：US11980743

    申请日：2007-10-31

    申请人： Wuu-Jyh Lin ,  Mao-Hsung Chang ,  Kuo-Yuan Chu ,  Dow-chi Chen ,  Ping-Yen Huang ,  Jenn-Tzong Chen ,  Ting-shien Duh

    发明人： Wuu-Jyh Lin ,  Mao-Hsung Chang ,  Kuo-Yuan Chu ,  Dow-chi Chen ,  Ping-Yen Huang ,  Jenn-Tzong Chen ,  Ting-shien Duh

    IPC分类号： F16K15/00

    CPC分类号： B01J4/008 ,  Y10T137/7838

    摘要： A liquid isotope delivery system includes a pressure-controlling unit, an input unit, a target chamber, a proton-radiating unit and a storage unit. The pressure-controlling unit includes a first regulating valve, a second regulating valve connected to the first regulating valve and a third regulating valve connected to the first regulating valve. The input unit is connected to the second regulating valve. The target chamber is connected to the third regulating valve and the input unit. The proton-radiating unit is located near the target chamber. The storage unit is connected to the target chamber.

    摘要翻译： 液体同位素输送系统包括压力控制单元，输入单元，目标室，质子辐射单元和存储单元。 压力控制单元包括第一调节阀，连接到第一调节阀的第二调节阀和连接到第一调节阀的第三调节阀。 输入单元连接到第二调节阀。 目标腔室连接到第三调节阀和输入单元。 质子辐射单元位于目标室附近。 存储单元连接到目标室。

    Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs
    9.
    发明申请
    Preparation method of radiation sensitive copolymer carrier for coating radiated nanoparticles and chemotherapy drugs 有权
    辐射敏感性纳米粒子和化疗药物辐射敏感性共聚物载体的制备方法

    公开(公告)号：US20160113884A1

    公开(公告)日：2016-04-28

    申请号：US14522583

    申请日：2014-10-24

    申请人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

    发明人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

    IPC分类号： A61K9/51 ,  A61K31/704

    CPC分类号： A61K9/5146 ,  A61K9/5192 ,  A61K31/704

    摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

    摘要翻译： 用于涂覆辐射纳米颗粒和/或化疗药物的辐射敏感性共聚物载体的制备方法包括通过二硒化物嵌段共聚物和DSPE-PEG-生物标志物形成纳米球，以涂覆可以从开放的纳米球释放的化学药物和/或辐射纳米颗粒， 在质子治疗期间质子穿透组织。 质子治疗的治疗效果通过使用从开放的纳米球释放的辐射纳米颗粒产生核裂变以释放电子以释放肿瘤的肿瘤细胞的质子和从打开的纳米球释放的化疗药物在组织间分布的两种方式得到增强 杀死肿瘤的癌细胞。