公开(公告)号：US06833920B2

公开(公告)日：2004-12-21

申请号：US10046620

申请日：2002-01-12

Applicant: William Rassman ,  David Ralin ,  Robert A. Lieberman ,  Lothar U. Kempen

Inventor： William Rassman ,  David Ralin ,  Robert A. Lieberman ,  Lothar U. Kempen

IPC: G01J400

CPC classification number: G01N21/211 ,  G01N21/253 ,  G01N21/552 ,  G01N2021/212 ,  Y10S436/805

Abstract: Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.

公开(公告)号：US07496267B2

公开(公告)日：2009-02-24

申请号：US11975030

申请日：2007-10-16

Applicant: Edgar A. Mendoza ,  Lothar U. Kempen ,  Robert A. Lieberman

Inventor： Edgar A. Mendoza ,  Lothar U. Kempen ,  Robert A. Lieberman

IPC: G02B6/10

CPC classification number: G02B6/12009 ,  G02B6/122 ,  G02B6/13 ,  G02B6/132 ,  G02B6/2821 ,  G02B2006/12107 ,  G02B2006/12119 ,  G02B2006/12173 ,  G02F1/01 ,  G02F1/0126 ,  G02F1/095 ,  G02F2001/0113 ,  G02F2201/307 ,  G02F2202/38 ,  H04J14/021

Abstract: A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.

Abstract translation: 含有有机金属光敏剂的光敏溶胶 - 凝胶膜沉积在硅衬底的含氧化物表面层上。 入射到光敏溶胶 - 凝胶膜的白色或紫外光的图案导致光敏剂从溶胶 - 凝胶膜的暴露区域的解离。 第一和第二加热步骤的后续连续导致首先从溶胶 - 凝胶膜的暴露区域去除光敏剂成分，其次，从曝光区域去除有机成分，导致区域掺杂 具有非线性光学性质的金属氧化物，例如半等离子体等。 可以制造光开关，耦合器，波导，分路器，干涉仪波分复用器，布拉格光栅等。 也可以使用玻璃基板代替硅，在这种情况下不需要单独的氧化硅表面层。

公开(公告)号：US07391948B2

公开(公告)日：2008-06-24

申请号：US11093275

申请日：2005-03-28

Applicant: Lothar U. Kempen ,  Rongchung Tyan ,  Edgar A. Mendoza

Inventor： Lothar U. Kempen ,  Rongchung Tyan ,  Edgar A. Mendoza

IPC: G02B6/26 ,  G02B6/10 ,  G02B6/12 ,  G02B6/14

CPC classification number: G02B6/1228 ,  G02B6/2821

Abstract: Waveguide structures in which light confinement strength varies along the direction of light propagation are described. The waveguides include a core adapted to propagate light along a path defined by the core and a cladding material that at least partially surrounds the core. The core and the cladding material each have a refractive index profile in the direction of light propagation. One or more of the profiles or lateral core dimensions are varied along the direction of light propagation, thereby causing the degree of light confinement to vary in the direction of light propagation. With such structures it is possible to tailor the velocity of the light propagating through the core and the confinement of the light to the core for any given core cross section. The structures may be used, for example, in mode-matching an input or output of a waveguide and in fabricating compact directional couplers.

Abstract translation: 描述光限制强度沿光传播方向变化的波导结构。 波导包括适于沿着由芯限定的路径传播光的芯和至少部分地围绕芯的包层材料。 芯和包层材料各自在光传播的方向上具有折射率分布。 轮廓或横向纤芯尺寸中的一个或多个沿着光传播的方向变化，从而导致光限制的程度在光传播的方向上变化。 通过这种结构，可以定制通过芯体传播的光的速度以及将光限制到核心以用于任何给定的核心横截面。 该结构可以用于例如波导的输入或输出的模式匹配以及制造紧凑的定向耦合器中。

公开(公告)号：US07283717B2

公开(公告)日：2007-10-16

申请号：US11386515

申请日：2006-03-21

Applicant: Edgar A. Mendoza ,  Lothar U. Kempen ,  Robert A. Lieberman

Inventor： Edgar A. Mendoza ,  Lothar U. Kempen ,  Robert A. Lieberman

IPC: G02B6/10

CPC classification number: G02B6/12009 ,  G02B6/122 ,  G02B6/13 ,  G02B6/132 ,  G02B6/2821 ,  G02B2006/12107 ,  G02B2006/12119 ,  G02B2006/12173 ,  G02F1/01 ,  G02F1/0126 ,  G02F1/095 ,  G02F2001/0113 ,  G02F2201/307 ,  G02F2202/38 ,  H04J14/021

Abstract: A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.

Abstract translation: 含有有机金属光敏剂的光敏溶胶 - 凝胶膜沉积在硅衬底的含氧化物表面层上。 入射到光敏溶胶 - 凝胶膜的白色或紫外光的图案导致光敏剂从溶胶 - 凝胶膜的暴露区域的解离。 第一和第二加热步骤的后续连续导致首先从溶胶 - 凝胶膜的暴露区域去除光敏剂成分，其次，从曝光区域去除有机成分，导致区域掺杂 具有非线性光学性质的金属氧化物，例如半等离子体等。 可以制造光开关，耦合器，波导，分路器，干涉仪波分复用器，布拉格光栅等。 也可以使用玻璃基板代替硅，在这种情况下不需要单独的氧化硅表面层。

公开(公告)号：US07016589B2

公开(公告)日：2006-03-21

申请号：US09574840

申请日：2000-05-19

Applicant: Edgar A. Mendoza ,  Lothar U. Kempen ,  Robert A. Lieberman

Inventor： Edgar A. Mendoza ,  Lothar U. Kempen ,  Robert A. Lieberman

IPC: G02B6/10

CPC classification number: G02B6/12009 ,  G02B6/122 ,  G02B6/13 ,  G02B6/132 ,  G02B6/2821 ,  G02B2006/12107 ,  G02B2006/12119 ,  G02B2006/12173 ,  G02F1/01 ,  G02F1/0126 ,  G02F1/095 ,  G02F2001/0113 ,  G02F2201/307 ,  G02F2202/38 ,  H04J14/021

Abstract: A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, electro-optic, magneto-optic, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.

Abstract translation: 含有有机金属光敏剂的光敏溶胶 - 凝胶膜沉积在硅衬底的含氧化物表面层上。 入射到光敏溶胶 - 凝胶膜的白色或紫外光的图案导致光敏剂从溶胶 - 凝胶膜的暴露区域的解离。 第一和第二加热步骤的后续连续导致，首先，从溶胶 - 凝胶膜的暴露区域去除光敏剂成分，其次，从曝光区域去除有机成分，导致区域掺杂 具有非线性光学性质的金属氧化物，例如半潜，电光，磁光等。 可以制造光开关，耦合器，波导，分路器，干涉仪波分复用器，布拉格光栅等。 也可以使用玻璃基板代替硅，在这种情况下不需要单独的氧化硅表面层。

公开(公告)号：US6052179A

公开(公告)日：2000-04-18

申请号：US59739

申请日：1998-04-14

Applicant: John D. Prohaska ,  Lothar U. Kempen ,  Robert A. Lieberman

Inventor： John D. Prohaska ,  Lothar U. Kempen ,  Robert A. Lieberman

IPC: G01B9/02 ,  G01D5/353

CPC classification number: G01D5/35335 ,  G01D5/35316

Abstract: A method of determining the wavelength of light transmitted in an optical fiber comprises the steps of filtering the light using a filter, and then detecting the filtered light, and then determining the wavelength of the filtered light. The filter comprises a fiber grating which is recorded in a portion of the optical fiber. The fiber grating preferably has a modulated index of refraction with a modulation amplitude that varies from a first end to a second end of the fiber grating, and a modulation period defined by a grating constant that varies from the first end to the second end of the fiber grating. The fiber grating at least partially prevents transmission of light within a wavelength spectrum, and prevents transmission of a substantially larger portion of the light at a first end of the wavelength spectrum than at a second end of the wavelength spectrum. Therefore, the wavelength of the filtered light can be determined by determining a proportion of the light which was transmitted by the filter. The proportion of light which is transmitted by the filter is preferably linearly related to the wavelength of the light.

Abstract translation: 确定在光纤中传输的光的波长的方法包括以下步骤：使用滤光片对光进行滤光，然后检测滤光，然后确定滤光的波长。 滤光器包括记录在光纤的一部分中的光纤光栅。 光纤光栅优选地具有从光纤光栅的第一端到第二端变化的调制幅度的调制折射率，以及由光栅常数变化的调制周期，该调制周期从第一端到第二端变化 光纤光栅。 光纤光栅至少部分地防止波长光谱中的光的透射，并且防止在波长光谱的第一端处的光的实质上较大部分的光在波长光谱的第二端的透射。 因此，可以通过确定由滤光器透射的光的比例来确定滤光光的波长。 由滤光器透射的光的比例优选与光的波长成线性关系。

公开(公告)号：US20080204750A1

公开(公告)日：2008-08-28

申请号：US12117245

申请日：2008-05-08

Applicant: William R Rassman ,  David Ralin ,  Jason D. Berger ,  Robert A. Lieberman ,  Lothar U. Kempen

Inventor： William R Rassman ,  David Ralin ,  Jason D. Berger ,  Robert A. Lieberman ,  Lothar U. Kempen

IPC: G01J4/00

CPC classification number: G06T7/0012 ,  G01N21/21 ,  G01N21/253 ,  G01N21/552 ,  G01N2021/212 ,  G06T2207/30072

Abstract: Image data is acquired, processed, and/or displayed in accordance with an embodiment of the present disclosure to display, monitor, and/or demonstrate the progress of an experiment substantially in real-time and with high sensitivity. In one embodiment, at least one time-resolved value of spatially distributed polarization change data is provided and displayed. Advantageously, real-time processing and display of data is provided such that discussion and collaboration about the experiment may occur, time-resolved data is not lost, and resources are not wasted.

Abstract translation: 根据本公开的实施例获取，处理和/或显示图像数据，以基本上实时且高灵敏度显示，监视和/或演示实验的进展。 在一个实施例中，提供和显示空间分布的偏振改变数据的至少一个时间分辨值。 有利地，提供数据的实时处理和显示，使得可能发生关于实验的讨论和协作，时间分辨数据不会丢失，并且资源不被浪费。

公开(公告)号：US06882420B2

公开(公告)日：2005-04-19

申请号：US10841988

申请日：2004-05-07

Applicant: William Rassman ,  David Ralin ,  Robert A. Lieberman ,  Lothar U. Kempen

Inventor： William Rassman ,  David Ralin ,  Robert A. Lieberman ,  Lothar U. Kempen

IPC: G01N21/25 ,  G01N21/55 ,  G01J4/00 ,  G01N33/557

CPC classification number: G01N21/211 ,  G01N21/253 ,  G01N21/552 ,  G01N2021/212 ,  Y10S436/805

Abstract: Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.

公开(公告)号：US06859280B2

公开(公告)日：2005-02-22

申请号：US10602555

申请日：2003-06-23

Applicant: Lothar U. Kempen

Inventor： Lothar U. Kempen

IPC: G01N21/25 ,  G01N21/55 ,  G01J4/00 ,  G01N33/557

CPC classification number: G01N21/21 ,  G01N21/253 ,  G01N21/552 ,  Y10S436/805

Abstract: Imaging apparatus and method which uses change of polarization state of a light beam passed through a total internal reflection structure by a single reflection at a TIR surface in which a specimen is placed in the evanescent field associated with the total internal reflection of the light beam, the specimen being the subject of biological, chemical or genetic investigation.

Abstract translation: 使用在TIR表面处的单一反射通过全内反射结构的光束的偏振状态的变化的成像装置和方法，其中样本被放置在与光束的全内反射相关联的消逝场中， 该标本是生物，化学或遗传调查的对象。

公开(公告)号：US06594011B1

公开(公告)日：2003-07-15

申请号：US09614503

申请日：2000-07-11

Applicant: Lothar U. Kempen

Inventor： Lothar U. Kempen

IPC: G01J400

CPC classification number: G01N21/21 ,  G01N21/253 ,  G01N21/552 ,  Y10S436/805

Abstract: Imaging apparatus and method which uses change of polarization state of a light beam passed through a total internal reflection structure by a single reflection at a TIR surface in which a specimen is placed in the evanescent field associated with the total internal reflection of the light beam, the specimen being the subject of biological, chemical or genetic investigation.

Abstract translation: 使用在TIR表面处的单一反射通过全内反射结构的光束的偏振状态的变化的成像装置和方法，其中样本被放置在与光束的全内反射相关联的消逝场中， 该标本是生物，化学或遗传调查的对象。