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公开(公告)号：US07518724B2
公开(公告)日：2009-04-14
申请号：US11321168
申请日：2005-12-29
CPC分类号： G06T7/0012 , G01N21/21 , G01N21/253 , G01N21/552 , G01N2021/212 , G06T2207/30072
摘要： Image data is acquired, processed, and/or displayed in accordance with an embodiment of the present disclosure to display, monitor, and/or demonstrate the progress of an experiment substantially in real-time and with high sensitivity. In one embodiment, at least one time-resolved value of spatially distributed polarization change data is provided and displayed. Advantageously, real-time processing and display of data is provided such that discussion and collaboration about the experiment may occur, time-resolved data is not lost, and resources are not wasted.
摘要翻译： 根据本公开的实施例获取，处理和/或显示图像数据，以基本上实时且高灵敏度显示，监视和/或演示实验的进展。 在一个实施例中，提供和显示空间分布的偏振改变数据的至少一个时间分辨值。 有利地，提供数据的实时处理和显示，使得可能发生关于实验的讨论和协作，时间分辨数据不会丢失，并且资源不被浪费。
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公开(公告)号：US20080204750A1
公开(公告)日：2008-08-28
申请号：US12117245
申请日：2008-05-08
IPC分类号： G01J4/00
CPC分类号： G06T7/0012 , G01N21/21 , G01N21/253 , G01N21/552 , G01N2021/212 , G06T2207/30072
摘要： Image data is acquired, processed, and/or displayed in accordance with an embodiment of the present disclosure to display, monitor, and/or demonstrate the progress of an experiment substantially in real-time and with high sensitivity. In one embodiment, at least one time-resolved value of spatially distributed polarization change data is provided and displayed. Advantageously, real-time processing and display of data is provided such that discussion and collaboration about the experiment may occur, time-resolved data is not lost, and resources are not wasted.
摘要翻译： 根据本公开的实施例获取，处理和/或显示图像数据，以基本上实时且高灵敏度显示，监视和/或演示实验的进展。 在一个实施例中，提供和显示空间分布的偏振改变数据的至少一个时间分辨值。 有利地，提供数据的实时处理和显示，使得可能发生关于实验的讨论和协作，时间分辨数据不会丢失，并且资源不被浪费。
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公开(公告)号：US06882420B2
公开(公告)日：2005-04-19
申请号：US10841988
申请日：2004-05-07
IPC分类号： G01N21/25 , G01N21/55 , G01J4/00 , G01N33/557
CPC分类号： G01N21/211 , G01N21/253 , G01N21/552 , G01N2021/212 , Y10S436/805
摘要： Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.
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公开(公告)号：US07002686B2
公开(公告)日：2006-02-21
申请号：US11021204
申请日：2004-12-22
IPC分类号： G01J4/00 , G01N33/557
CPC分类号： G01N21/211 , G01N21/253 , G01N21/552 , G01N2021/212 , Y10S436/805
摘要： Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.
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公开(公告)号：US07193711B2
公开(公告)日：2007-03-20
申请号：US10847736
申请日：2004-05-17
IPC分类号： G01J4/00
CPC分类号： G01N21/211 , G01N21/21 , G01N21/253 , G01N21/552 , G01N2021/212 , Y10S436/805
摘要： An imaging method and apparatus are provided, including a light source emitting a polarized light beam, and an optical assembly including a control layer and/or a light reflection surface. The control layer advantageously allows for control over the properties of a generated evanescent wave to optimize an image of a specimen array within the evanescent wave. The light reflection surface includes coupling means used to couple a receptor/capture agent advantageously allowing for flexible control over receptor specific regions.
摘要翻译： 提供一种成像方法和装置，包括发射偏振光束的光源和包括控制层和/或光反射表面的光学组件。 控制层有利地允许控制所产生的ev逝波的性质以优化ev逝波内的样本阵列的图像。 光反射表面包括用于耦合受体/捕获剂的偶联装置，其有利地允许对受体特异性区域的灵活控制。
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公开(公告)号：US07126688B2
公开(公告)日：2006-10-24
申请号：US10847754
申请日：2004-05-17
IPC分类号： G01J4/00
CPC分类号： G01N21/253 , G01N21/21 , G01N21/211 , G01N21/552 , G01N33/54373 , G01N2021/212
摘要： Methods and apparatus for scanning of a microarray to provide an image of the microarray are disclosed. Data related to change in polarization state of a scanning light beam for individual points or lines or other portion of the microarray are collected and processed to image the microarray at high resolution and speed.
摘要翻译： 公开了用于扫描微阵列以提供微阵列图像的方法和装置。 收集和处理与单个点或线或微阵列的其他部分的扫描光束的偏振状态变化相关的数据，以高分辨率和速度对微阵列进行成像。
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公开(公告)号：US06833920B2
公开(公告)日：2004-12-21
申请号：US10046620
申请日：2002-01-12
IPC分类号： G01J400
CPC分类号： G01N21/211 , G01N21/253 , G01N21/552 , G01N2021/212 , Y10S436/805
摘要： Apparatus for acquiring an image of a specimen comprising a cassette having an optical portion holding a specimen array on a TIR surface and being removably matable to a processing portion having a polarized light beam source and a processing polarization-sensitive portion to image the spatially distributed charges in polarization of the specimen array. In one form the array optical portion comprises a transparent slide having a bottom surface with first and second gratings located to direct polarized light to the TIR surface and to direct light reflected by that (TIR) surface to an imager, respectively. The apparatus may include a flow cell integral with the optical portion as well as means for selecting the direction and wavelength of the polarized light.
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公开(公告)号：US06201912B1
公开(公告)日：2001-03-13
申请号：US09434225
申请日：1999-11-05
IPC分类号： G02B634
CPC分类号： G01L1/246 , G01D5/344 , G01D5/35383 , G01R33/0327 , G02B6/021 , G02B6/02109 , G02B6/02195 , G02B6/278 , G02B6/29319
摘要： A sensor system comprises a broadband light source, a birefringent sensor, a detection circuit, and a signal processing unit. The preferred detection circuit further includes a variable frequency oscillator, a modulator, and a photodetector. The modulator modulates the output of the birefringent sensor with a modulation signal from the variable frequency oscillator. The modulation produces an interference signal having a variable interference frequency. By determining the frequency of the modulation signal from the variable frequency oscillator that minimizes the interference frequency, the detection system is able to determine the difference in frequency between first and second spectral components of the output of birefringent sensor. The detector may be constructed using entirely solid state optics/electronics. The preferred fiber grating sensor comprises a birefringent optical fiber having a cladding and a core. The cladding has first and second side holes formed therein that extend substantially parallel to the core, and that are substantially coextensively located with respect to each other along the length of the optical fiber. The first and second side holes are preferable positioned such that, in transverse cross section of the optical fiber, a first radial line that extends from the core to the first side hole is substantially perpendicular to a second radial line that extends from the core to the second side hole.
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9.发明授权Integrated optic devices and photosensitive sol-gel process for producing integrated optic devices 失效用于生产集成光学器件的集成光学器件和光敏溶胶 - 凝胶法公开(公告)号：US07496267B2
公开(公告)日：2009-02-24
申请号：US11975030
申请日：2007-10-16
IPC分类号： G02B6/10
CPC分类号： G02B6/12009 , G02B6/122 , G02B6/13 , G02B6/132 , G02B6/2821 , G02B2006/12107 , G02B2006/12119 , G02B2006/12173 , G02F1/01 , G02F1/0126 , G02F1/095 , G02F2001/0113 , G02F2201/307 , G02F2202/38 , H04J14/021
摘要： A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.
摘要翻译： 含有有机金属光敏剂的光敏溶胶 - 凝胶膜沉积在硅衬底的含氧化物表面层上。 入射到光敏溶胶 - 凝胶膜的白色或紫外光的图案导致光敏剂从溶胶 - 凝胶膜的暴露区域的解离。 第一和第二加热步骤的后续连续导致首先从溶胶 - 凝胶膜的暴露区域去除光敏剂成分，其次，从曝光区域去除有机成分，导致区域掺杂 具有非线性光学性质的金属氧化物，例如半等离子体等。 可以制造光开关，耦合器，波导，分路器，干涉仪波分复用器，布拉格光栅等。 也可以使用玻璃基板代替硅，在这种情况下不需要单独的氧化硅表面层。
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10.发明授权Integrated optic devices and photosensitive sol-gel process for producing integrated optic devices 失效用于生产集成光学器件的集成光学器件和光敏溶胶 - 凝胶法公开(公告)号：US07283717B2
公开(公告)日：2007-10-16
申请号：US11386515
申请日：2006-03-21
IPC分类号： G02B6/10
CPC分类号： G02B6/12009 , G02B6/122 , G02B6/13 , G02B6/132 , G02B6/2821 , G02B2006/12107 , G02B2006/12119 , G02B2006/12173 , G02F1/01 , G02F1/0126 , G02F1/095 , G02F2001/0113 , G02F2201/307 , G02F2202/38 , H04J14/021
摘要： A photosensitive sol-gel film containing an organometallic photosensitizer is deposited on the oxide containing surface layer of a silicon substrate. A pattern of white or ultra violet light incident to the photosensitive sol-gel film results in the unbinding of the photosensitizer from the exposed regions of the sol-gel film. A subsequent succession of first and second heating steps results in, first, the removal of the photo sensitizer constituents from the exposed regions of the sol-gel film and, second, the removal of the organic constituents from the exposed regions, resulting in regions doped with a metal oxide with non linear optical properties, such as semicondutive, etc. properties. Optical switches, couplers, waveguides, splitters, interferometers wavelength division multiplexer, Bragg gratings and more can be fabricated. A glass substrate also may be employed, instead of a silicon, in which case a separate silicon oxide surface layer is unnecessary.
摘要翻译： 含有有机金属光敏剂的光敏溶胶 - 凝胶膜沉积在硅衬底的含氧化物表面层上。 入射到光敏溶胶 - 凝胶膜的白色或紫外光的图案导致光敏剂从溶胶 - 凝胶膜的暴露区域的解离。 第一和第二加热步骤的后续连续导致首先从溶胶 - 凝胶膜的暴露区域去除光敏剂成分，其次，从曝光区域去除有机成分，导致区域掺杂 具有非线性光学性质的金属氧化物，例如半等离子体等。 可以制造光开关，耦合器，波导，分路器，干涉仪波分复用器，布拉格光栅等。 也可以使用玻璃基板代替硅，在这种情况下不需要单独的氧化硅表面层。
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