公开(公告)号：US06643538B1

公开(公告)日：2003-11-04

申请号：US09693190

申请日：2000-10-20

申请人： Stanislaw Majewski ,  Vladimir Popov ,  Georgii Loutts

发明人： Stanislaw Majewski ,  Vladimir Popov ,  Georgii Loutts

IPC分类号： A61B600

CPC分类号： G01T1/161 ,  A61B1/042 ,  A61B1/313 ,  A61B6/4258 ,  G01T1/2008

摘要： An introperative surgical probe incorporating both a fiber optic imaging system and multi-element beta/gamma radiation directional indicating system is described.

摘要翻译： 描述了并入光纤成像系统和多元素β/γ辐射方向指示系统的入门手术探针。

公开(公告)号：US06389098B1

公开(公告)日：2002-05-14

申请号：US09425409

申请日：1999-10-25

申请人： Cynthia E. Keppel ,  Fernando Jorge Barbosa ,  Stanislaw Majewski

发明人： Cynthia E. Keppel ,  Fernando Jorge Barbosa ,  Stanislaw Majewski

IPC分类号： A61B604

CPC分类号： A61B6/4258 ,  A61B6/502 ,  A61B90/10 ,  A61B90/36 ,  A61B2090/371 ,  A61B2090/376

摘要： The invention described herein combines the structural digital X-ray image provided by conventional stereotactic core biopsy instruments with the additional functional metabolic gamma imaging obtained with a dedicated compact gamma imaging mini-camera. Before the procedure, the patient is injected with an appropriate radiopharmaceutical. The radiopharmaceutical uptake distribution within the breast under compression in a conventional examination table expressed by the intensity of gamma emissions is obtained for comparison (co-registration) with the digital mammography (X-ray) image. This dual modality mode of operation greatly increases the functionality of existing stereotactic biopsy devices by yielding a much smaller number of false positives than would be produced using X-ray images alone. The ability to obtain both the X-ray mammographic image and the nuclear-based medicine gamma image using a single device is made possible largely through the use of a novel, small and movable gamma imaging camera that permits its incorporation into the same table or system as that currently utilized to obtain X-ray based mammographic images for localization of lesions.

摘要翻译： 本文描述的发明将由常规立体定向核心活检器械提供的结构数字X射线图像与用专用的紧凑型伽马成像微型摄像机获得的附加的功能性代谢γ成像结合在一起。 在手术之前，患者注射适当的放射性药物。 为了与数字乳腺X线照相术（X线）图像进行比较（共同配对），获得由伽马发射强度表示的常规检查表中在压缩下乳房内的放射性药物吸收分布。 这种双重模式操作模式通过产生比仅使用X射线图像产生的假阳性数量少得多的数量，大大增加了现有立体定向活检装置的功能。 使用单一设备获得X射线乳腺摄影图像和基于核的药物伽玛图像的能力主要通过使用新颖的小型和可移动的伽马成像照相机来实现，其允许其结合到相同的表或系统中 如目前用于获得用于定位病变的基于X射线的乳房X线照相图像。

公开(公告)号：US5864141A

公开(公告)日：1999-01-26

申请号：US898731

申请日：1997-07-23

申请人： Stanislaw Majewski ,  Andrew G. Weisenberger ,  Randolph F. Wojcik ,  Daniela Steinbach

发明人： Stanislaw Majewski ,  Andrew G. Weisenberger ,  Randolph F. Wojcik ,  Daniela Steinbach

IPC分类号： G01T1/164 ,  G01T1/202 ,  G01T1/20

CPC分类号： G01T1/1644 ,  A61B6/4258 ,  G01T1/202

摘要： A high resolution gamma ray imaging device includes an aluminum housing, a lead screen collimator at an opened end of the housing, a crystal scintillator array mounted behind the lead screen collimator, a foam layer between the lead screen collimator and the crystal scintillator array, a photomultiplier window coupled to the crystal with optical coupling grease, a photomultiplier having a dynode chain body and a base voltage divider with anodes, anode wire amplifiers each connected to four anodes and a multi pin connector having pin connections to each anode wire amplifier. In one embodiment the crystal scintillator array includes a yttrium aluminum perovskite (YAP) crystal array. In an alternate embodiment, the crystal scintillator array includes a gadolinium oxyorthosilicate (GSO) crystal array.

摘要翻译： 高分辨率伽马射线成像装置包括铝壳体，壳体开口端的引线屏准直器，安装在引线屏准直器后面的晶体闪烁体阵列，引线屏准直器和晶体闪烁体阵列之间的泡沫层， 光电倍增器窗口，其耦合到具有光耦合润滑脂的晶体，具有倍增极链体的光电倍增管和具有阳极的基极分压器，每个连接到四个阳极的阳极线放大器和具有到每个阳极线放大器的引脚连接的多针连接器。 在一个实施例中，晶体闪烁体阵列包括钇铝钙钛矿（YAP）晶体阵列。 在替代实施例中，晶体闪烁体阵列包括氧化硅酸钆（GSO）晶体阵列。

公开(公告)号：US5568532A

公开(公告)日：1996-10-22

申请号：US289918

申请日：1994-08-12

申请人： Stanislaw Majewski ,  Brian J. Kross ,  Carl J. Zorn ,  Lukasz A. Majewski

发明人： Stanislaw Majewski ,  Brian J. Kross ,  Carl J. Zorn ,  Lukasz A. Majewski

IPC分类号： A61B6/00 ,  A61B6/14 ,  G01N23/04 ,  H05G1/64

CPC分类号： H05G1/64 ,  A61B6/145 ,  A61B6/4028 ,  A61B6/425 ,  G01N23/04

摘要： An optimized examination system and method based on the Reverse Geometry X-Ray.RTM. (RGX.RTM.) radiography technique are presented. The examination system comprises a radiation source, at least one flexible, miniature radiation detector probe positioned in appropriate proximity to the object to be examined and to the radiation source with the object located between the source and the probe, a photodetector device attachable to an end of the miniature radiation probe, and a control unit integrated with a display device connected to the photodetector device. The miniature radiation detector probe comprises a scintillation element, a flexible light guide having a first end optically coupled to the scintillation element and having a second end attachable to the photodetector device, and an opaque, environmentally-resistant sheath surrounding the flexible light guide. The probe may be portable and insertable, or may be fixed in place within the object to be examined. An enclosed, flexible, liquid light guide is also presented, which comprises a thin-walled flexible tube, a liquid, preferably mineral oil, contained within the tube, a scintillation element located at a first end of the tube, closures located at both ends of the tube, and an opaque, environmentally-resistant sheath surrounding the flexible tube. The examination system and method have applications in non-destructive material testing for voids, cracks, and corrosion, and may be used in areas containing hazardous materials. In addition, the system and method have applications for medical and dental imaging.

摘要翻译： 提出了基于反向几何X射线TM（RGX TM）射线照相技术的优化检测系统和方法。 检查系统包括辐射源，至少一个柔性的微型辐射探测器探头，其定位在适当接近待检测物体的位置，并且辐射源与物体位于源和探头之间，光电检测器可连接到一端 的微型辐射探头，以及与连接到光电检测器装置的显示装置集成的控制单元。 微型辐射探测器探头包括闪烁元件，柔性光导，其具有与闪烁元件光学耦合的第一端，并具有可连接到光电检测器件的第二端，以及围绕柔性光导的不透明的环保护套。 探头可以是便携式的和可插入的，或者可以固定在被检查物体内的适当位置。 还提供了一种封闭的，柔性的液体光导，其包括薄壁柔性管，容纳在管内的液体，优选矿物油，位于管的第一端的闪烁元件，位于两端的封闭件 的管，以及围绕柔性管的不透明的，耐环境的护套。 检测系统和方法适用于空隙，裂纹和腐蚀的无损材料试验，可用于含有危险物质的区域。 此外，该系统和方法具有医疗和牙科成像的应用。

公开(公告)号：US09784852B1

公开(公告)日：2017-10-10

申请号：US11707579

申请日：2007-02-16

申请人： Stanislaw Majewski ,  Andrew G. Weisenberger

发明人： Stanislaw Majewski ,  Andrew G. Weisenberger

IPC分类号： A61B6/00 ,  G01T1/20 ,  G01T1/161 ,  G01T1/16 ,  A61N5/10

CPC分类号： G01T1/2008 ,  A61B6/4208 ,  A61B6/4258 ,  A61B6/4266 ,  A61B6/4405 ,  A61N5/103 ,  G01T1/1603 ,  G01T1/161 ,  G01T1/1642

摘要： A surgical guidance system offering different levels of imaging capability while maintaining the same hand-held convenient small size of light-weight intra-operative probes. The surgical guidance system includes a second detector, typically an imager, located behind the area of surgical interest to form a coincidence guidance system with the hand-held probe. This approach is focused on the detection of positron emitting biomarkers with gamma rays accompanying positron emissions from the radiolabeled nuclei.

公开(公告)号：US09356166B2

公开(公告)日：2016-05-31

申请号：US13904183

申请日：2013-05-29

申请人： Alexander Stolin ,  Stanislaw Majewski ,  Raymond Raylman

发明人： Alexander Stolin ,  Stanislaw Majewski ,  Raymond Raylman

IPC分类号： H01L31/024 ,  G01J1/04 ,  G01T1/20 ,  G01J1/02

CPC分类号： H01L31/024 ,  G01J1/0252 ,  G01J1/0425 ,  G01T1/2018

摘要： A cooled optical light guide is provided having a conduit having a translucent top and a translucent bottom wherein at least a portion of the translucent top of the conduit is in alignment above at least a portion of the translucent bottom of the conduit. A fluid medium that is preferably cooled flows through the conduit. The optical light guide is placed between a scintillator array and an array detector. The temperature of the light that is emitted by the scintillator array is stabilized, and preferably cooled, as it passes through the translucent bottom of the conduit and through the translucent top of the conduit for detection by the array detector. A method of temperature stabilization for photomultiplier based detectors is disclosed.

摘要翻译： 提供了一种冷却的光学光导，其具有具有半透明顶部和半透明底部的导管，其中导管的半透明顶部的至少一部分在导管的半透明底部的至少一部分上方对准。 优选冷却的流体介质流过导管。 光学光导被放置在闪烁体阵列和阵列检测器之间。 由闪烁体阵列发射的光的温度稳定，并且优选地冷却，因为它通过导管的半透明底部并且通过导管的半透明顶部，由阵列检测器检测。 公开了一种基于光电倍增管的检测器的温度稳定方法。

公开(公告)号：US20140275965A1

公开(公告)日：2014-09-18

申请号：US13827557

申请日：2013-03-14

申请人： Stanislaw Majewski ,  James Proffitt ,  James Lewis ,  Julie Brefczynski-Lewis ,  Alexander Stolin

发明人： Stanislaw Majewski ,  James Proffitt ,  James Lewis ,  Julie Brefczynski-Lewis ,  Alexander Stolin

IPC分类号： G01R33/48

CPC分类号： G01R33/481 ,  G01T1/1603 ,  G01T1/2985

摘要： A Positron Emission Tomography (PET″) insert for use with a Magnetic Resonance Imaging (“MRI”) scanning device, the PET insert including a plurality of photodetector modules provided adjacent each other in an array, the plurality of photodetector modules configured for placement adjacent a body of a patient and sized to be received in a magnetic bore of the MRI scanning device with the patient, the photodetector modules providing detection of gamma annihilation photons, and a Radio Frequency (“RF”) coil provided between the patient and the plurality of photodetector modules. Each of the plurality of photodetector modules includes a pixelated scintillator array provided for alignment adjacent the patient's body, and a shielding block including silicon photomultiplier pads and passive electronic circuitry only.

摘要翻译： 用于与磁共振成像（“MRI”）扫描装置一起使用的正电子发射断层扫描（PET“）插入物，所述PET插入物包括以阵列相邻设置的多个光电检测器模块，所述多个光电检测器模块被配置为邻近放置 患者的身体，并且被设计成被容纳在患者的MRI扫描装置的磁性孔中，所述光检测器模块提供伽马湮灭光子的检测，以及设置在患者与多个之间的射频（“RF”）线圈 的光电检测器模块。 多个光检测器模块中的每一个包括用于与患者身体相邻的对准的像素化闪烁体阵列，以及仅包括硅光电倍增管和无源电子电路的屏蔽块。

公开(公告)号：US07884331B2

公开(公告)日：2011-02-08

申请号：US12284285

申请日：2008-09-19

申请人： Stanislaw Majewski ,  James Proffitt

发明人： Stanislaw Majewski ,  James Proffitt

IPC分类号： G01T1/161

CPC分类号： G01T1/00 ,  A61B6/037

摘要： A brain imager includes a compact ring-like static PET imager mounted in a helmet-like structure. When attached to a patient's head, the helmet-like brain imager maintains the relative head-to-imager geometry fixed through the whole imaging procedure. The brain imaging helmet contains radiation sensors and minimal front-end electronics. A flexible mechanical suspension/harness system supports the weight of the helmet thereby allowing for patient to have limited movements of the head during imaging scans. The compact ring-like PET imager enables very high resolution imaging of neurological brain functions, cancer, and effects of trauma using a rather simple mobile scanner with limited space needs for use and storage.

摘要翻译： 大脑成像器包括安装在头盔状结构中的紧凑的环状静态PET成像器。 头盔般的大脑成像仪连接到患者的头部时，通过整个成像过程维持相对的头对头几何尺寸。 脑成像头盔包含辐射传感器和最小化的前端电子设备。 灵活的机械悬挂/线束系统支撑头盔的重量，从而允许患者在成像扫描期间具有头部的有限运动。 紧凑的环状PET成像仪可以使用相当简单的移动扫描仪对神经功能，癌症和创伤的影响进行非常高分辨率的成像，并且空间需求有限。

公开(公告)号：US07732774B2

公开(公告)日：2010-06-08

申请号：US12284287

申请日：2008-09-19

申请人： Stanislaw Majewski

发明人： Stanislaw Majewski

IPC分类号： G01T1/164

CPC分类号： G01T1/00 ,  A61B6/037 ,  G01T1/2008

摘要： A highly efficient PET breast imager for detecting lesions in the entire breast including those located close to the patient's chest wall. The breast imager includes a ring of imaging modules surrounding the imaged breast. Each imaging module includes a slant imaging light guide inserted between a gamma radiation sensor and a photodetector. The slant light guide permits the gamma radiation sensors to be placed in close proximity to the skin of the chest wall thereby extending the sensitive region of the imager to the base of the breast. Several types of photodetectors are proposed for use in the detector modules, with compact silicon photomultipliers as the preferred choice, due to its high compactness. The geometry of the detector heads and the arrangement of the detector ring significantly reduce dead regions thereby improving detection efficiency for lesions located close to the chest wall.

摘要翻译： 一种高效PET乳房成像仪，用于检测整个乳房中的病变，包括靠近患者胸壁的病灶。 乳房成像器包括围绕成像乳房的成像模块环。 每个成像模块包括插入在γ辐射传感器和光电检测器之间的倾斜成像光导。 倾斜的光导允许伽马射线传感器放置在靠近胸壁的皮肤上，从而将成像器的敏感区域延伸到乳房的底部。 提出了几种类型的光电探测器用于检测器模块，由于其高度紧凑性，使用紧凑型硅光电倍增管作为优选选择。 检测器头的几何形状和检测环的布置显着减少了死区，从而提高了位于靠近胸壁的病变的检测效率。

公开(公告)号：US06271525B1

公开(公告)日：2001-08-07

申请号：US09159177

申请日：1998-09-23

申请人： Stanislaw Majewski ,  Andrew G. Weisenberger ,  Randolph F. Wojcik

发明人： Stanislaw Majewski ,  Andrew G. Weisenberger ,  Randolph F. Wojcik

IPC分类号： G01T1202

CPC分类号： G01T1/1642 ,  A61B6/4258 ,  G01T1/1644

摘要： A gamma camera comprising essentially and in order from the front outer or gamma ray impinging surface: 1) a collimator, 2) a scintillator layer, 3) a light guide, 4) an array of position sensitive, high resolution photomultiplier tubes, and 5) printed circuitry for receipt of the output of the photomultipliers. There is also described, a system wherein the output supplied by the high resolution, position sensitive photomultipiler tubes is communicated to: a) a digitizer and b) a computer where it is processed using advanced image processing techniques and a specific algorithm to calculate the center of gravity of any abnormality observed during imaging, and c) optional image display and telecommunications ports.

摘要翻译： 一种伽马照相机，其基本上和从前外射线或伽马射线的入射面依次包括：1）准直器，2）闪烁体层，3）光导，4）阵列的位置敏感的高分辨率光电倍增管和5 ）印刷电路，用于接收光电倍增管的输出。 还描述了一种系统，其中由高分辨率，位置敏感的光电多层管提供的输出被传送到：a）数字转换器和b）使用高级图像处理技术和特定算法来计算中心的计算机 在成像期间观察到的任何异常的重力，以及c）可选的图像显示和电信端口。