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11.发明申请6, 9-Disubstituted Purine Derivatives and Their Use as Cosmetics and Cosmetic Compositions 有权6,9-二取代嘌呤衍生物及其作为化妆品和化妆品组合物的用途公开(公告)号：US20110230503A1
公开(公告)日：2011-09-22
申请号：US13116725
申请日：2011-05-26
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Jiri Voller , Karel Dolezal , Miroslav Strnad , Frank J. Massino
CPC分类号： C07D473/00
摘要： Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are provided. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.
摘要翻译： 提供了某些6,9-二取代的嘌呤衍生物及其药学上可接受的盐。 这些6,9-二取代的嘌呤衍生物及其药学上可接受的盐可用于治疗哺乳动物细胞，特别是人类皮肤细胞的组合物，以改善老化的不利影响，治疗皮肤疾病状态，治疗由于或相关的 与炎症等。
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12.发明申请公开(公告)号：US20110224238A1
公开(公告)日：2011-09-15
申请号：US13116636
申请日：2011-05-26
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frolich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frolich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
CPC分类号： A61K8/49 , A61K8/4953 , A61K9/0014 , A61K31/52 , A61Q19/08
摘要： The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
摘要翻译： 本发明提供了用于抵抗老化对体外和体内哺乳动物细胞，特别是人皮肤细胞和人皮肤的不利影响以及哺乳动物过度增殖和相关皮肤疾病的治疗的方法和组合物，通过施用含有6,9-二取代 嘌呤衍生物
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13.发明申请公开(公告)号：US20100234401A1
公开(公告)日：2010-09-16
申请号：US12786027
申请日：2010-05-24
申请人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frohlich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatloukal , Lukas Spichal , Ludek Frohlich , Karel Dolezal , Miroslav Strnad , Frank J. Massino
CPC分类号： A61K8/49 , A61K8/4953 , A61K9/0014 , A61K31/52 , A61Q19/08
摘要： The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
摘要翻译： 本发明提供了用于抵抗老化对体外和体内哺乳动物细胞，特别是人皮肤细胞和人皮肤的不利影响以及哺乳动物过度增殖和相关皮肤疾病的治疗的方法和组合物，通过施用含有6,9-二取代 嘌呤衍生物
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14.发明授权Substitution derivatives of N6 -benzyladenosine-5′-monophosphate, methods of preparation thereof, use thereof as medicaments, and therapeutic preparations containing these compounds 有权N6-苄基腺苷-5'-单磷酸的取代衍生物，其制备方法，作为药物的用途，以及含有这些化合物的治疗制剂公开(公告)号：US09073961B2
公开(公告)日：2015-07-07
申请号：US13642905
申请日：2011-04-28
申请人： Marek Zatloukal , Karel Dolezal , Jiri Voller , Lukas Spichal , Miroslav Strnad
发明人： Marek Zatloukal , Karel Dolezal , Jiri Voller , Lukas Spichal , Miroslav Strnad
IPC分类号： C07H19/20 , A61K31/7068 , C07H19/167
CPC分类号： C07H19/167 , A61K31/7068 , C07H19/20
摘要： The invention relates to substitution derivatives of N6-benzyladenosine-5′-monophosphate of the general formula I, wherein (R)n represents 1 to 4 substituents (n is in the range 1-4), which can be the same or different, and R is selected from the group comprising C1 to C8 alkyl, C1 to C8 alkoxy, amino, halogen, hydroxy, mercapto and nitro groups, and the pharmaceutically acceptable salts thereof. This invention also relates to methods of their preparation, their use as medicaments and in other biotechnological applications, and a therapeutic composition containing these derivatives.
摘要翻译： 本发明涉及通式I的N6-苄基腺苷-5'-一磷酸的取代衍生物，其中（R）n表示1〜4个取代基（n在1-4的范围内），其可以相同或不同， 并且R选自C1至C8烷基，C1至C8烷氧基，氨基，卤素，羟基，巯基和硝基的基团及其药学上可接受的盐。 本发明还涉及其制备方法，它们作为药物和其它生物技术应用的用途，以及含有这些衍生物的治疗组合物。
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15.发明申请SUBSTITUTION DERIVATIVES OF N6-BENZYLADENOSINE-5' -MONOPHOSPHATE, METHODS OF PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, AND THERAPEUTIC PREPARATIONS CONTAINING THESE COMPOUNDS 有权N6-苄基腺苷-5'-磷酸酯的替代衍生物，其制备方法，作为药物的用途，以及含有这些化合物的治疗剂公开(公告)号：US20130040908A1
公开(公告)日：2013-02-14
申请号：US13642905
申请日：2011-04-28
申请人： Marek Zatloukal , Karel Dolezal , Jiri Voller , Lukas Spichal , Miroslav Strnad
发明人： Marek Zatloukal , Karel Dolezal , Jiri Voller , Lukas Spichal , Miroslav Strnad
IPC分类号： C07H19/20 , A61P37/06 , A61P35/00 , A61P35/02 , A61P19/06 , A61P3/10 , A61P25/00 , A61P25/28 , A61P33/00 , A61K31/7076 , A61P19/02
CPC分类号： C07H19/167 , A61K31/7068 , C07H19/20
摘要： Substitution derivatives of N6-benzyladenosine-5′-monophosphate of the general formula I, wherein (R)n represents 1 to 4 substituents (n is in the range 1-4), which can be the same or different, and R is selected from the group comprising C1 to C8 alkyl, C1 to C8 alkoxy, amino, halogen, hydroxy, mercapto and nitro groups, and the pharmaceutically acceptable salts thereof. A Method for their preparation, their use as medicaments and in other applications, and a therapeutic composition containing these derivatives is also disclosed.
摘要翻译： 通式I的N6-苄基腺苷-5'-一磷酸的取代衍生物，其中（R）n表示1至4个取代基（n在1-4），其可以相同或不同，并且选择R 包括C1至C8烷基，C1至C8烷氧基，氨基，卤素，羟基，巯基和硝基的基团及其药学上可接受的盐。 还公开了其制备方法，它们作为药物和其它用途的用途，以及含有这些衍生物的治疗组合物。
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公开(公告)号：US20130072506A1
公开(公告)日：2013-03-21
申请号：US13611491
申请日：2012-09-12
申请人： Lenka ZAHAJSKA , Jan Hanus , Lukas Spichal , Jiri Voller , Miroslav Strnad
发明人： Lenka ZAHAJSKA , Jan Hanus , Lukas Spichal , Jiri Voller , Miroslav Strnad
IPC分类号： A61K31/522 , C07D473/34 , A61Q19/08 , A61K8/49 , C12N5/071 , C07D473/36 , A61K31/52 , C07D473/32
CPC分类号： C07D473/34 , A61K8/4953 , A61Q19/00 , A61Q19/08 , C12N5/0625
摘要： 6,8-Disubstituted purines which can be used in drug and cosmetic compositions and/or applications are provided. These 6,8-disubstituted purines have a wide range of biological activities, including for example anti-inflammatory, anti-senescent, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. The 6,8-disubstituted purine compounds and compositions containing such 6,8-disubstituted purines provide growth-regulatory, differentiating, antisenescent and antiaging properties with improved selectivities and efficiencies and lower toxicities than analogues known heretofore.
摘要翻译： 提供了可用于药物和化妆品组合物和/或应用中的6,8-二取代嘌呤。 这些6,8-二取代的嘌呤具有广泛的生物活性，包括例如抗炎，抗衰老，以及其它在制药和化妆品应用中特别有用的活性。 含有这种6,8-二取代嘌呤的6,8-二取代嘌呤化合物和组合物提供生长调节，分化，抗衰老和抗衰老特性，与迄今为止已知的类似物相比具有改进的选择性和效率以及较低的毒性。
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17.发明申请公开(公告)号：US20130072505A1
公开(公告)日：2013-03-21
申请号：US13630673
申请日：2012-09-28
申请人： Lucie Szucova , Marek Zatioukai , Lukas Spichal , Ludek Frohich , Karel Dolezal , Miroslav Stmad , Frank J. Massino
发明人： Lucie Szucova , Marek Zatioukai , Lukas Spichal , Ludek Frohich , Karel Dolezal , Miroslav Stmad , Frank J. Massino
CPC分类号： A61K8/49 , A61K8/4953 , A61K9/0014 , A61K31/52 , A61Q19/08
摘要： The present invention provides methods and compositions for countering the adverse effects of aging on mammalian cells in vitro and in vivo, especially human skin cells and human skin, and treatment of hyperproliferative and related skin diseases in mammals by administering compositions containing 6,9-disubstituted purine derivatives.
摘要翻译： 本发明提供了用于抵抗老化对体外和体内哺乳动物细胞，特别是人皮肤细胞和人皮肤的不利影响以及哺乳动物过度增殖和相关皮肤疾病的治疗的方法和组合物，通过施用含有6,9-二取代 嘌呤衍生物
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