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公开(公告)号：US20080119488A1
公开(公告)日：2008-05-22
申请号：US11572579
申请日：2005-07-24
申请人： Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens , Haixia Wang , Yinong Xie , Lynne Canne Bannen , Diva Sze-Ming Chan , Ping Huang , Vasu Jammalamadaka , Richard G. Khoury , Morrison B. Mac , Jason Jevious Parks , Yong Wang , Wei Xu
发明人： Christopher D. Bayne , Alan T. Johnson , Shao-Po Lu , Raju Mohan , Michael C. Nyman , Edwin J. Schweiger , William C. Stevens , Haixia Wang , Yinong Xie , Lynne Canne Bannen , Diva Sze-Ming Chan , Ping Huang , Vasu Jammalamadaka , Richard G. Khoury , Morrison B. Mac , Jason Jevious Parks , Yong Wang , Wei Xu
IPC分类号： A61K31/497 , C07D211/98 , A61K31/4418 , C07D401/12 , A61K31/513 , C07D401/04 , A61K31/443 , A61P3/00 , A61P25/00 , C12N5/06 , C07K14/00 , A61P9/00 , A61P17/10 , A61K31/4433 , C07D401/14 , A61K31/4439 , A61K31/4545 , C07D409/04 , A61K31/4436
CPC分类号： C07D401/12 , C07D213/84 , C07D213/85 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12
摘要： Compounds of the invention, such as compounds of formula (I), where n, m, A, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明的化合物，例如式（I）化合物，其中n，m，A，R 1，R 2，R 3，R 4和R 5在本文中定义，可用作肝X受体活性的调节剂。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US08476298B2
公开(公告)日：2013-07-02
申请号：US11753503
申请日：2007-05-24
申请人： Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrisson B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wie Xu
发明人： Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrisson B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wie Xu
IPC分类号： A01N43/42 , A61K31/47 , C07D239/72
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US07579473B2
公开(公告)日：2009-08-25
申请号：US12393806
申请日：2009-02-26
申请人： Lynne Canne Bannen , Diva Sze-Ming Chan , Timothy Patrick Forsyth , Richard George Khoury , James William Leahy , Morrisson B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wie Xu
发明人： Lynne Canne Bannen , Diva Sze-Ming Chan , Timothy Patrick Forsyth , Richard George Khoury , James William Leahy , Morrisson B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wie Xu
IPC分类号： C07D215/38 , A61K31/47
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US08067436B2
公开(公告)日：2011-11-29
申请号：US11753514
申请日：2007-05-24
申请人： Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrisson B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wie Xu
发明人： Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrisson B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wie Xu
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/517 , A61K31/5377
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US07989622B2
公开(公告)日：2011-08-02
申请号：US11988862
申请日：2006-10-09
申请人： William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison B. Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
发明人： William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison B. Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
IPC分类号： A61K31/4985 , A61K31/498 , C07D241/36 , C07D403/14 , C07D471/04 , A61P35/02 , A61P35/00
CPC分类号： C07D401/12 , C07D241/44 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/55
摘要： The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.
摘要翻译： 本发明包括与许多恶性肿瘤如卵巢癌，宫颈癌，乳腺癌，结肠癌，直肠癌和成胶质细胞瘤等相关的磷脂酰肌醇3-激酶（PI3K）的小分子抑制剂。 因此，本发明的化合物可用于治疗，预防和/或抑制这些疾病。
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公开(公告)号：US20100087440A1
公开(公告)日：2010-04-08
申请号：US11988862
申请日：2006-10-09
申请人： William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison B. Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
发明人： William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison B. Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
IPC分类号： A61K31/4985 , C07D241/36 , C07D403/14 , C07D471/04 , A61K31/498 , A61P35/02 , A61P35/00
CPC分类号： C07D401/12 , C07D241/44 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/55
摘要： The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.
摘要翻译： 本发明包括与许多恶性肿瘤如卵巢癌，宫颈癌，乳腺癌，结肠癌，直肠癌和成胶质细胞瘤等相关的磷脂酰肌醇3-激酶（PI3K）的小分子抑制剂。 因此，本发明的化合物可用于治疗，预防和/或抑制这些疾病。
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公开(公告)号：US08178532B2
公开(公告)日：2012-05-15
申请号：US11753462
申请日：2007-05-24
申请人： Lynne Canne Bannen , Diva Sze-Ming Chan , Timothy Patrick Forsyth , Richard George Khoury , James William Leahy , Morrisson B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wie Xu
发明人： Lynne Canne Bannen , Diva Sze-Ming Chan , Timothy Patrick Forsyth , Richard George Khoury , James William Leahy , Morrisson B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wie Xu
IPC分类号： A61K31/535 , C07D413/00
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
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公开(公告)号：US07977345B2
公开(公告)日：2011-07-12
申请号：US11571140
申请日：2005-07-01
申请人： Lynne Canne Bannen , Diva Sze-Ming Chan , Lisa Esther Dalrymple , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrisson B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wie Xu
发明人： Lynne Canne Bannen , Diva Sze-Ming Chan , Lisa Esther Dalrymple , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrisson B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wie Xu
IPC分类号： C07D487/04 , A61K31/519 , A61K31/522
CPC分类号： C07D487/04 , C07D209/52 , C07D471/04 , C07D473/30 , C07D473/32 , C07D493/04 , C07D493/14 , C07D493/20 , C07D498/04
摘要： A compound for modulating kinase activity according to Formula I, or a pharmaceutically acceptable salt thereof, Wherein J1, J2, J3, R2, J4, Z, Ar and R3 are as defined in the specification, compositions thereof, and methods of use thereof.
摘要翻译： 用于调节根据式I的激酶活性的化合物或其药学上可接受的盐，其中J1，J2，J3，R2，J4，Z，Ar和R3如说明书，其组合物及其使用方法中所定义。
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公开(公告)号：US08013156B2
公开(公告)日：2011-09-06
申请号：US10549300
申请日：2004-03-19
申请人： Lynne Canne Bannen , S. David Brown , Wei Cheng , Vasu Jammalamadaka , John M. Nuss , Morrison B. Mac , Jason Jevious Parks , Matthew A. Williams , Wei Xu , Atwood Kim Cheung , Lisa Esther Dalrymple , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , James William Leahy , Gary Lee Lewis , Robin Tammie Noguchi , Larry Wayne Mann , Brian Hugh Ridgway , Joan C. Sangalang , Kevin Luke Schnepp , Xian Shi , Richard George Khoury
发明人： Lynne Canne Bannen , S. David Brown , Wei Cheng , Vasu Jammalamadaka , John M. Nuss , Morrison B. Mac , Jason Jevious Parks , Matthew A. Williams , Wei Xu , Atwood Kim Cheung , Lisa Esther Dalrymple , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , James William Leahy , Gary Lee Lewis , Robin Tammie Noguchi , Larry Wayne Mann , Brian Hugh Ridgway , Joan C. Sangalang , Kevin Luke Schnepp , Xian Shi , Richard George Khoury
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4425 , A61K31/495 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
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公开(公告)号：US20100105953A1
公开(公告)日：2010-04-29
申请号：US12605118
申请日：2009-10-23
申请人： Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
发明人： Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
IPC分类号： C07C315/00
CPC分类号： C07D241/04 , C07C309/87 , C07D213/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/06
摘要： The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
摘要翻译： 本发明提供了用于抑制ADAM-10蛋白质的化合物，具有选择性对MMP-1。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。 相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。
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