公开(公告)号：US09366651B2

公开(公告)日：2016-06-14

申请号：US14322756

申请日：2014-07-02

Applicant: MATRIX SENSORS, INC.

Inventor： Michael D Cable ,  Heinrich Sussner ,  Steven Yamamoto

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N29/02 ,  G01N29/028 ,  G01N29/036 ,  G01N29/24

CPC classification number: G01N29/2406 ,  B05D1/005 ,  G01N29/022 ,  G01N29/028 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/54393 ,  G01N33/552 ,  G01N33/553 ,  G01N2291/014 ,  G01N2291/018 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/0427 ,  G01N2291/106

Abstract: Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A first sensor in the array includes a first resonating member having a first surface comprising a receptor material coated over a first underlying material. A second sensor includes a second resonating member having a second surface comprising the receptor material coated over a second underlying material that is different than the first underlying material. The first underlying material, the second underlying material, and the receptor material are selected such that the first resonating member, having a combination of the receptor material and the first underlying material, has a different ability to adsorb or bind a mass of one or more analytes than does the second resonating member having a combination of the receptor material with the second underlying material. Methods for fabricating sensors with surface modifications are also provided.

Abstract translation: 对阵列中的传感器的表面改性给传感器提供了吸附或结合分子的不同功能。 阵列中的第一传感器包括具有第一表面的第一谐振元件，第一谐振元件包括涂覆在第一底层材料上的受体材料。 第二传感器包括具有第二表面的第二谐振元件，该第二表面包括被覆在不同于第一基础材料的第二下层材料上的受体材料。 选择第一基础材料，第二基础材料和受体材料，使得具有受体材料和第一下面材料的组合的第一谐振构件具有不同的吸附或结合一个或多个 分析物比具有受体材料与第二下面材料的组合的第二共振构件相同。 还提供了用于制造具有表面改性的传感器的方法。

公开(公告)号：US20150011428A1

公开(公告)日：2015-01-08

申请号：US14322756

申请日：2014-07-02

Applicant: MATRIX SENSORS, INC.

Inventor： Michael D. Cable ,  Heinrich Sussner ,  Steven Yamamoto

IPC: G01N29/02 ,  G01N33/00 ,  G01N27/22 ,  G01N33/543

CPC classification number: G01N29/2406 ,  B05D1/005 ,  G01N29/022 ,  G01N29/028 ,  G01N29/036 ,  G01N33/0031 ,  G01N33/54393 ,  G01N33/552 ,  G01N33/553 ,  G01N2291/014 ,  G01N2291/018 ,  G01N2291/021 ,  G01N2291/022 ,  G01N2291/0427 ,  G01N2291/106

Abstract: Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A first sensor in the array includes a first resonating member having a first surface comprising a polymer receptor material coated over a first underlying material. A second sensor includes a second resonating member having a second surface comprising the polymer receptor material coated over a second underlying material that is different than the first underlying material. The first underlying material, the second underlying material, and the polymer receptor material are selected such that the first resonating member, having a combination of the polymer receptor material and the first underlying material, has a different ability to adsorb or bind a mass of one or more analytes than does the second resonating member having a combination of the polymer receptor material with the second underlying material. Methods for fabricating sensors with surface modifications are also provided.

Abstract translation: 对阵列中的传感器的表面改性给传感器提供了吸附或结合分子的不同功能。 阵列中的第一传感器包括第一谐振构件，其具有包含涂覆在第一下层材料上的聚合物受体材料的第一表面。 第二传感器包括具有第二表面的第二谐振元件，该第二表面包括聚合物受体材料，所述第二表面涂覆在不同于第一底层材料的第二底层材料上。 选择第一基础材料，第二基础材料和聚合物受体材料，使得具有聚合物受体材料和第一下面材料的组合的第一谐振构件具有不同的吸附或粘合一个物质的能力 或更多的分析物比具有聚合物受体材料与第二下面材料的组合的第二共振构件相同。 还提供了用于制造具有表面改性的传感器的方法。

公开(公告)号：US11643751B2

公开(公告)日：2023-05-09

申请号：US17198204

申请日：2021-03-10

Applicant: MATRIX SENSORS, INC.

Inventor： David K Britt ,  Paul R Wilkinson ,  Steven Yamamoto

IPC: C30B28/04 ,  C08J5/18 ,  C07F15/04 ,  G01G3/16 ,  C30B29/58 ,  C07F9/00

CPC classification number: C30B28/04 ,  C07F9/00 ,  C07F15/04 ,  C08J5/18 ,  C30B29/58 ,  G01G3/165

Abstract: An apparatus and method is provided for coating a surface of a material with a film of porous coordination polymer. A first substrate having a first surface to be coated is positioned in a processing chamber such that the first surface is placed in a substantially opposing relationship to a second surface. In some embodiments, the second surface is provided by a wall of the processing chamber, and in other embodiments the second surface is provided by a second substrate to be coated. The first substrate is held such that a gap exists between the first and second surfaces, and the gap is filled with at least one reaction mixture comprising reagents sufficient to form the crystalline film on at least the first surface. A thin gap (e.g., having a thickness less than 2 mm) between the first and second surfaces is effective for producing a high quality film having a thickness less than 100 μm. Confining the volume of the reaction mixture to a thin layer adjacent the substrate surface significantly reduces problems with sedimentation and concentration control. In some embodiments, the size, shape, or average thickness of the gap is adjusted during formation of the film in response to feedback from at least one film growth monitor.

公开(公告)号：US20220082525A1

公开(公告)日：2022-03-17

申请号：US17470748

申请日：2021-09-09

Applicant: MATRIX SENSORS, INC.

Inventor： David K Britt ,  Paul R Wilkinson ,  Steven Yamamoto

IPC: G01N29/036 ,  G01N27/22 ,  G01K11/26 ,  G01N33/00 ,  F25B21/04

Abstract: A sensor device comprises at least one transducer and a sensing material disposed on the transducer. The sensing material adsorbs or absorbs an amount of analyte (e.g., a target gas) that depends on a temperature of the sensing material and a concentration of the analyte. At least one detector is arranged to measure responses of the transducer to sorption or desorption of the analyte in the sensing material while the sensing material is heated and/or cooled according to at least one temperature profile. The device also comprises a humidity sensor that is arranged to detect a humidity level of the environment or sample containing the analyte. A processor or controller is programmed to determine the quantity (e.g., concentration) of the analyte by comparing values of the transducer measurement signals to reference data indicative of expected or pre-measured responses of the transducer to known concentrations of the analyte at the same humidity level as indicated by the humidity sensor while the sensing material is subjected to the same or similar temperature profile.

公开(公告)号：US20170023511A1

公开(公告)日：2017-01-26

申请号：US14660870

申请日：2015-03-17

Applicant: MATRIX SENSORS, INC.

Inventor： Paul R. Wilkinson ,  Steven Yamamoto

IPC: G01N27/22 ,  G01L1/10

CPC classification number: G01L1/10 ,  G01N27/221 ,  G01N27/4163 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2406 ,  G01N29/4427 ,  G01N33/0006 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106

Abstract: An array of resonant sensors self-corrects measured values for the effects of environmental conditions, such as operating temperature, pressure or humidity. The resonant sensors have varied frequency responses to N environmental parameters and M chemical parameters. Each of the sensors has a different, non-zero frequency response to at least two of the parameters. The device also comprises at least one detector for detecting frequency responses of the resonant sensors. Individual parameter values are determined for each of the N environmental parameters and M chemical parameters according to the detected frequency responses and a system of equations using calibration terms that relate the frequency responses to the individual parameter values.

Abstract translation: 谐振传感器阵列可自动校正环境条件（如工作温度，压力或湿度）影响的测量值。 谐振传感器对N个环境参数和M个化学参数具有不同的频率响应。 每个传感器对至少两个参数具有不同的非零频率响应。 该装置还包括用于检测谐振传感器的频率响应的至少一个检测器。 根据检测到的频率响应，确定N个环境参数和M个化学参数中的每一个的各个参数值​​，以及使用将频率响应与各个参数值​​相关联的校准项的方程组。

公开(公告)号：US20150192548A1

公开(公告)日：2015-07-09

申请号：US14592896

申请日：2015-01-08

Applicant: MATRIX SENSORS, INC.

Inventor： Paul R. Wilkinson ,  Steven Yamamoto

IPC: G01N29/12 ,  G01N29/34

CPC classification number: G01N29/036 ,  G01N29/022 ,  G01N29/2406 ,  G01N29/2437 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106

Abstract: A sensor array comprises resonant sensors and porous receptor materials arranged on the resonant sensors to absorb or adsorb one or more analytes. The average pore size of the porous receptor materials on the sensors increases systematically from one sensor to the next in the array. At least one detector is arranged to detect responses of the resonant sensors when the array is exposed to a sample potentially containing one or more of the analytes. In some embodiments, a processor is programmed to determine from the sensor responses the presence, amount or relative concentration of target molecules in the sample.

Abstract translation: 传感器阵列包括布置在谐振传感器上以吸收或吸附一种或多种分析物的谐振传感器和多孔接收材料。 传感器上的多孔接收材料的平均孔径从阵列中的一个传感器到下一个传感器系统地增加。 当阵列暴露于潜在地含有一种或多种分析物的样品时，布置至少一个检测器以检测谐振传感器的响应。 在一些实施例中，处理器被编程为从传感器响应确定样品中靶分子的存在，量或相对浓度。

公开(公告)号：US10436737B2

公开(公告)日：2019-10-08

申请号：US15872999

申请日：2018-01-17

Applicant: MATRIX SENSORS, INC.

Inventor： Heinrich Sussner ,  Paul R Wilkinson ,  Steven Yamamoto ,  David K Britt

IPC: A61B5/055 ,  G01N27/327 ,  G01N27/02 ,  G01N29/00 ,  G01N29/02 ,  G01N29/036 ,  G01N29/24 ,  G01N29/44 ,  A61B5/00 ,  A61B5/145

Abstract: A device and method are provided for detecting analyte with correction for the effects of humidity. The device comprises a resonant sensor having an oscillating portion. A capacitor is positioned on the oscillating portion. The capacitor is formed by at least two electrodes and a sensing material positioned between the electrodes. A readout circuit is arranged to measure a response of the oscillating portion (e.g., frequency shift or change in resonance frequency, stiffness or strain) and a capacitance of the capacitor when substances are adsorbed or absorbed in the sensing material. This combination of measurements enables the device to distinguish between various types of adsorbed or absorbed molecules, especially distinguishing between an analyte of interest and water molecules that might interfere with the detection of the analyte. A processor determines an analyte value indicative of the presence, amount or concentration of the analyte in dependence upon measurements of both the response of the oscillating portion and the capacitance to account for the effects of water in the sensing material.

公开(公告)号：US20190255510A1

公开(公告)日：2019-08-22

申请号：US16398005

申请日：2019-04-29

Applicant: MATRIX SENSORS, INC.

Inventor： David K. Britt ,  Paul R. Wilkinson ,  Steven Yamamoto

IPC: B01J20/22

Abstract: An apparatus and method is provided for coating a surface of a substrate with at least one film of porous coordination polymer. A body (e.g., a flow cell) has an interior space for holding the substrate to be coated, at least one inlet, and at least one outlet in communication with the interior space to permit fluid to flow in a downstream direction from the inlet, across the surface of the substrate in the interior space, and through the outlet. A plurality of flow channels are arranged to flow a plurality of different reagent solutions from respective supply sources to the at least one inlet. The flow channels merge into at least one mixing region, positioned upstream of the interior space, to mix the solutions prior to the mixture contacting the surface of the substrate in the interior space. At least one pressure source and valve system are arranged with the supply sources and the flow channels to select at least one combination of the reagent solutions to be mixed and to force the selected reagent solutions to flow from their respective supply sources, through the flow channels, and into the mixing region at different, independently controllable flow rates to regulate respective concentrations of reagents in the mixture.

公开(公告)号：US20190072523A1

公开(公告)日：2019-03-07

申请号：US16118159

申请日：2018-08-30

Applicant: MATRIX SENSORS, INC.

Inventor： David K. Britt ,  Paul R. Wilkinson ,  Steven Yamamoto

IPC: G01N29/02 ,  G01N29/22 ,  G01N33/00

Abstract: A gas sensor comprises at least one transducer and a sensing material (e.g., a metal-organic framework) disposed on the transducer. The sensing material has a temperature-dependent gas sorption behavior. A detector is arranged to detect responses of the transducer to sorption and/or desorption of a target gas in the sensing material and to output transducer measurement signals indicative of the transducer responses. At least one thermal element changes the temperature of the sensing material by heating and/or cooling, and at least one temperature sensor (which may be integral with the thermal element) is arranged to measure a temperature of the sensing material. At least one processor determines the quantity (e.g., concentration, partial pressure, or mass) of the target gas according to the temperature of the sensing material at which the transducer measurement signals satisfy a signal value condition.

公开(公告)号：US10036730B2

公开(公告)日：2018-07-31

申请号：US14592896

申请日：2015-01-08

Applicant: MATRIX SENSORS, INC.

Inventor： Paul R Wilkinson ,  Steven Yamamoto

IPC: G01N29/036 ,  G01N29/02 ,  G01N29/24

CPC classification number: G01N29/036 ,  G01N29/022 ,  G01N29/2406 ,  G01N29/2437 ,  G01N2291/0256 ,  G01N2291/0427 ,  G01N2291/106

Abstract: A sensor array comprises resonant sensors and porous receptor materials arranged on the resonant sensors to absorb or adsorb one or more analytes. The average pore size of the porous receptor materials on the sensors increases systematically from one sensor to the next in the array. At least one detector is arranged to detect responses of the resonant sensors when the array is exposed to a sample potentially containing one or more of the analytes. In some embodiments, a processor is programmed to determine from the sensor responses the presence, amount or relative concentration of target molecules in the sample.