公开(公告)号：US20210283403A1

公开(公告)日：2021-09-16

申请号：US17337530

申请日：2021-06-03

Applicant: Medtronic, Inc.

Inventor： Richard M.T. Lu ,  Subham Ghosh ,  Robert W. Stadler

IPC: A61N1/37 ,  A61N1/362 ,  A61N1/368 ,  A61B5/361

Abstract: The present disclosure pertains to cardiac pacing methods and systems, and, more particularly, to cardiac resynchronization therapy (CRT). In particular, the present disclosure pertains to determining whether a patient is experiencing atrial fibrillation (AF). If the patient is experiencing AF, the efficacy of CRT is determined. A signal is sensed in response to a ventricular pacing stimulus. Through signal processing, a number of features are parsed from the signal and a determination is made as to whether the ventricular pacing stimulus evoked a response from the ventricle.

公开(公告)号：US11013925B2

公开(公告)日：2021-05-25

申请号：US16005943

申请日：2018-06-12

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Juan Du ,  Saul E. Greenhut ,  Michael T. Hemming

IPC: A61B5/00 ,  A61N1/368 ,  A61N1/375 ,  A61N1/365 ,  A61B5/35 ,  A61B5/287 ,  A61B5/349 ,  A61N1/362

Abstract: A medical device and medical device system for controlling delivery of therapeutic stimulation pulses that includes a sensing device to sense a cardiac signal and emit a trigger signal in response to the sensed cardiac signal, a therapy delivery device to receive the trigger signal and deliver therapy to the patient in response to the emitted trigger signal, and a processor positioned within the sensing device, the processor configured to determine whether the sensed cardiac signal exceeds a possible P-wave threshold, compare a portion of the sensed cardiac signal to a P-wave template having a sensing window having a length less than a width of the P-wave, confirm an occurrence of a P-wave signal in response to the comparing, emit the trigger signal in response to the occurrence of a P-wave signal being confirmed, and inhibit delivery of the emitting signal in response to the occurrence of a P-wave signal not being confirmed.

公开(公告)号：US10940321B2

公开(公告)日：2021-03-09

申请号：US15995406

申请日：2018-06-01

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Karen Kleckner ,  Melissa Rhodes ,  D'Anne Kudlik ,  Jordyn Reich ,  Keelia Doyle ,  Joshua Blauer

IPC: A61N1/372 ,  A61B34/20 ,  A61N1/39 ,  A61B5/00 ,  A61B5/0408 ,  A61B5/044 ,  A61B5/0452 ,  A61B17/34 ,  A61N1/02 ,  A61N1/365 ,  A61N1/368

Abstract: Systems, interfaces, and methods are described herein for evaluation and adjustment cardiac therapy. The systems, interfaces, and methods may utilize, or include, a graphical user interface to display various information with respect to a plurality of external electrodes and electrical activity monitored using such external electrodes and to allow a user to adjust what information to display.

公开(公告)号：US10918863B2

公开(公告)日：2021-02-16

申请号：US16047625

申请日：2018-07-27

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Karen J. Kleckner

IPC: A61B5/0452 ,  A61N1/36 ,  A61B5/0408 ,  A61B5/0531 ,  A61N1/04 ,  A61N1/362 ,  A61B5/00 ,  A61B5/0468 ,  A61B5/024 ,  A61B5/0472 ,  A61B5/0464 ,  A61B5/0456

Abstract: Systems and methods are described herein for generating surrogate cardiac electrical activation times from electrical activity monitored by a plurality of external electrodes. Surrogate cardiac electrical activation times that should be corrected may be identified, or determined, according to one or more metrics, and then such surrogate cardiac electrical activation times may be corrected according to various criterion.

公开(公告)号：US20200306544A1

公开(公告)日：2020-10-01

申请号：US16369948

申请日：2019-03-29

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Aleksandre Sambelashvili ,  Jeffrey Gillberg ,  Manfred Justen ,  Sean Farrell

IPC: A61N1/368 ,  A61B5/0408

Abstract: Systems, methods, and devices are described herein for evaluation, adjustment, and delivery of adaptive cardiac therapy. The systems, methods, and devices may utilize electrical heterogeneity information to determine and/or select one or more pacing settings and pacing type or configurations for a plurality of different heart rates. The adaptive cardiac therapy may deliver cardiac therapy at selected pacing settings such as, for example, A-V and/or V-V intervals, according to a presently measured heart rate and switch between left ventricular-only or biventricular cardiac pacing therapy also according to the presently measured heart rate.

公开(公告)号：US10780281B2

公开(公告)日：2020-09-22

申请号：US15934517

申请日：2018-03-23

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Zhongping Yang

IPC: A61N1/368 ,  A61B5/0408 ,  A61N1/365 ,  A61N1/37 ,  A61N1/362 ,  A61N1/04 ,  A61B5/04 ,  A61B5/00 ,  A61B5/0456 ,  A61B5/0464 ,  A61B5/0472

Abstract: Cardiac electrical heterogeneity information may be used to determine whether one or more ventricle from atrium (VfA) paced settings for VfA pacing therapy are acceptable. Cardiac electrical heterogeneity information may be generated during VfA pacing, and then evaluated to determine whether the VfA paced settings are acceptable.

公开(公告)号：US20200230415A1

公开(公告)日：2020-07-23

申请号：US16840083

申请日：2020-04-03

Applicant: Medtronic, Inc.

Inventor： Zhongping Yang ,  Thomas A. Anderson ,  Brian P. Colin ,  William J. Clemens ,  Subham Ghosh ,  Jeffrey M. Gillberg ,  Maurice T.I. Verbeek ,  Toine Camps ,  Lilian Kornet ,  Berthold Stegemann ,  Jean Rutten

IPC: A61N1/368 ,  A61N1/05 ,  A61N1/362 ,  A61N1/372 ,  A61N1/375

Abstract: VfA cardiac therapy uses an implantable medical device or system. The implantable medical device includes a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The device may include a right atrial electrode, a right atrial motion detector, or both. The device may be implanted completely within the patient's heart or may use one or more leads to implant electrodes in the patient's heart. The device may be used to provide cardiac therapy, including single or multiple chamber pacing, atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A separate medical device may be used to provide some functionality for cardiac therapy, such as sensing, pacing, or shock therapy.

公开(公告)号：US10653886B2

公开(公告)日：2020-05-19

申请号：US15222302

申请日：2016-07-28

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh

IPC: A61N1/37 ,  A61B5/042 ,  A61N1/368 ,  A61N1/365 ,  A61N1/375 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/0468 ,  A61N1/372 ,  A61N1/05 ,  A61N1/39 ,  A61B5/00 ,  A61N1/362

Abstract: A medical device and medical device system for delivering left ventricular pacing that includes a subcutaneous sensing device having a subcutaneous electrode to sense a subcutaneous cardiac signal and an emitting device to emit a trigger signal in response to the sensed cardiac signal, an intracardiac therapy delivery device to deliver the left ventricular pacing in response to the emitted trigger signal, and a processor configured to determine whether the medical device system is in one of a VVD pacing mode and a VVI pacing mode, determine whether the delivered left ventricular pacing captures the left ventricle, determine whether to adjust a pacing parameter in response to the determination of whether the device system is in one of a VVD pacing mode and a VVI pacing mode and the determination of whether the delivered left ventricular pacing captures the left ventricle, and deliver the left ventricular pacing in response to determining whether to adjust the pacing parameter.

公开(公告)号：US10532213B2

公开(公告)日：2020-01-14

申请号：US15909585

申请日：2018-03-01

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh

IPC: A61N1/368 ,  A61N1/365 ,  A61N1/37 ,  A61B5/0464 ,  A61B5/0452 ,  A61B5/0472 ,  A61N1/05 ,  A61B5/042

Abstract: A cardiac pacemaker is disclosed for pacing cardiac tissue to improve synchrony between the atria and ventricles and/or between the left and right ventricles. A pulse generator is configured to deliver a pacing pulse to a patient's ventricle at an atrioventricular (AV) delay following a preceding atrial event. A sensing circuitry configured to sense a signal from the patient's ventricle following delivery of a said pacing pulse. A processing circuitry coupled to the pulse generator and the sensing circuitry and configured to control the pulse generator, the processing circuitry further configured to: (1) acquire from the sensed signal a set of features; (2) determine whether the ventricular pacing pulse effectively captures the patient's ventricle using the set of features; (3) determine whether one or more tissue latency conditions are present. The one or more pacing pulse parameters are adjusted, in response to determining that tissue latency is present.

公开(公告)号：US10433746B2

公开(公告)日：2019-10-08

申请号：US16229224

申请日：2018-12-21

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  MEDTRONIC, INC. ,  ALLINA HEALTH SYSTEM

Inventor： Subham Ghosh ,  Antonia E. Curtin ,  Alan J. Bank ,  Ryan M. Gage ,  Kevin V. Burns ,  Jeffrey M. Gillberg ,  Juan Du

IPC: A61B5/0408 ,  A61B5/04 ,  A61B5/00 ,  A61N1/362 ,  A61N1/39 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472

Abstract: The exemplary systems, methods, and interfaces may obtain and analyze electrode signals from a plurality of external electrodes. The electrode signals may include at least an anterior set of electrode signals and a posterior set of electrode signals. The anterior and posterior sets of electrode signals may be used to generate, or provide, various metrics of cardiac electrical heterogeneity and various graphical depictions that may be useful in assessing a patient's cardiac functionality.