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    Individualizable dosage form
    12.
    发明申请
    Individualizable dosage form 审中-公开
    可个性化的剂型

    公开(公告)号：US20100068235A1

    公开(公告)日：2010-03-18

    申请号：US12284015

    申请日：2008-09-16

    申请人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    发明人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    IPC分类号： A61K9/24 ,  A61K8/02

    CPC分类号： A61K9/28 ,  A61K9/0009 ,  G06F19/3462

    摘要： Provided embodiments include a final dosage form, an article of manufacture, and a method. A final dosage form for delivering a medicament to an animal is provided. The final dosage form includes an outer layer. The final dosage form also includes a release element configured in a first medicament-release state and modifiable to a second medicament-release state upon an ex vivo exposure to a stimulus. The final dosage form further includes a chamber at least substantially within the outer layer and configured to carry the medicament. The final dosage form further includes a containment element configured to retain the medicament within the final dosage form until the dosage form is administered to the animal. The final dosage form includes the medicament. The final dosage form may include an indicator element configured to indicate an exposure of the release element to the stimulus.

    摘要翻译： 所提供的实施方案包括最终剂型，制品和方法。 提供了用于将药物递送至动物的最终剂型。 最终剂型包括外层。 最终剂型还包括配置在第一药物释放状态中的释放元件，并且在体外暴露于刺激物时可修改为第二药物释放状态。 最终剂型还包括至少基本上在外层内并且构造成携带药物的腔室。 最终剂型还包括构造成将药物保持在最终剂型中直到将该剂型施用于动物的容纳元件。 最终剂型包括药物。 最终剂型可以包括指示元件，其被配置为指示释放元件暴露于刺激。

    Ex VIVO modifiable particle or polymeric material medicament carrier
    14.
    发明申请
    Ex VIVO modifiable particle or polymeric material medicament carrier 审中-公开
    Ex VIVO可改性的颗粒或聚合物材料药物载体

    公开(公告)号：US20100068283A1

    公开(公告)日：2010-03-18

    申请号：US12387312

    申请日：2009-04-29

    申请人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    发明人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    IPC分类号： A61K9/14

    CPC分类号： G06F19/3456 ,  A61K9/06 ,  A61K9/127 ,  A61K9/4891 ,  A61K9/51

    摘要： Described embodiments include a final dosage form, an article of manufacture, and method. A final dosage form for administering a medicament to an animal is described. The final dosage form includes the medicament. The final dosage form also includes a particle or polymeric material carrying the medicament in a first medicament-release state wherein the medicament is available to the animal in a first bioavailability if the final dosage form is administered to the animal. The particle or polymeric material is modifiable ex vivo by an exposure to a stimulus to carry the medicament in a second medicament-release state wherein the medicament is available to the animal in a second bioavailability if the final dosage form is administered to the animal. In an embodiment, the final dosage form further includes a transport medium suitable for delivering the particle or polymeric material binding the medicament to the animal.

    摘要翻译： 描述的实施方案包括最终剂型，制品和方法。 描述了向动物施用药物的最终剂型。 最终剂型包括药物。 最终剂型还包括在第一药物释放状态下携带药物的颗粒或聚合物质，其中如果向动物施用最终剂型，则药物可以以第一生物利用度获得。 颗粒或聚合物材料可以通过暴露于刺激物来离体修饰，以在第二药物释放状态下携带药物，其中如果向动物施用最终剂型，则药物可以以第二生物利用度获得。 在一个实施方案中，最终剂型还包括适于将结合药物的颗粒或聚合物质输送到动物的转运介质。

    Ex vivo modifiable medicament release-substance
    17.
    发明申请
    Ex vivo modifiable medicament release-substance 审中-公开
    离体可改性的药物释放物质

    公开(公告)号：US20100068256A1

    公开(公告)日：2010-03-18

    申请号：US12387311

    申请日：2009-04-29

    申请人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    发明人： Mahalaxmi Gita Bangera ,  Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Dennis J. Rivet ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    IPC分类号： A61K9/127 ,  A61K9/10

    CPC分类号： G06F19/3456 ,  A61K9/06 ,  A61K9/127 ,  A61K9/4891 ,  A61K9/51

    摘要： A described final dosage form includes a substance carrying a medicament in a first medicament-release state having a first bioavailability. The substance is modifiable ex vivo by an exposure to a first stimulus to carry the medicament in a second medicament-release state having a second bioavailability. The substance is modifiable ex vivo by an exposure to a second stimulus to carry the medicament in a third medicament-release state having a third bioavailability. The final dosage form includes another substance carrying another medicament in another first medicament-release state having another first bioavailability. The another substance is modifiable ex vivo by an exposure to another first stimulus to carry the another medicament in another second medicament-release state having another second bioavailability. The another substance is modifiable ex vivo by an exposure to another second stimulus to carry the another medicament in another third medicament-release state having another third bioavailability.

    摘要翻译： 所描述的最终剂型包括携带具有第一生物利用度的第一药物释放状态的药物的物质。 该物质可以通过暴露于第一次刺激而离体修饰，以使药物在具有第二生物利用度的第二药物释放状态下携带。 该物质可通过暴露于第二刺激物离体修饰以携带具有第三生物利用度的第三药物释放状态的药物。 最终剂型包括在另一第一药物释放状态下携带具有另一第一生物利用度的另一药物的另一物质。 另一种物质可以通过暴露于另一种第一刺激离体来修饰，以携带具有另一第二生物利用度的另一第二药物释放状态的另一种药物。 通过暴露于另一第二刺激物，另一种物质可以通过暴露于另一种第二刺激来进行修饰，从而将另一种药物置于具有另一种第三生物利用度的另一种第三药物释