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公开(公告)号:US20100052898A1
公开(公告)日:2010-03-04
申请号:US12231061
申请日:2008-08-27
申请人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: G08B1/08
CPC分类号: A61B5/6833 , A61B5/01 , A61B5/02007 , A61B5/04 , A61B5/0816 , A61B5/1112 , A61B5/202 , A61B5/411 , A61B5/4875 , A61B5/6804 , A61B5/681 , A61B5/6831
摘要: Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.
摘要翻译: 描述了用于配置和使用由衣物制品定位的显示器,扬声器或其他输出设备的系统和方法,例如在诊所或安老院设置中,医疗保健接收者可佩戴其他此类结构。
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公开(公告)号:US20100056873A1
公开(公告)日:2010-03-04
申请号:US12231048
申请日:2008-08-27
申请人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
摘要: Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.
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公开(公告)号:US20100052915A1
公开(公告)日:2010-03-04
申请号:US12231050
申请日:2008-08-27
申请人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: G08B23/00
CPC分类号: A61B5/411 , A61B5/0013 , A61B2560/0412 , G06F19/00 , G16H40/20
摘要: Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.
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公开(公告)号:US20100052892A1
公开(公告)日:2010-03-04
申请号:US12231053
申请日:2008-08-27
申请人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号: A61B5/002 , A61B5/01 , A61B5/02007 , A61B5/02028 , A61B5/1113 , A61B5/411 , A61B5/681 , A61B5/6813 , A61B2560/0242 , A61B2560/0412 , G06F19/00 , G06F19/3418
摘要: Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.
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公开(公告)号:US20100052897A1
公开(公告)日:2010-03-04
申请号:US12231049
申请日:2008-08-27
申请人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Paul G. Allen , Edward S. Boyden , Mahalaxmi Gita Bangera , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号: A61B5/411 , A61B5/0013 , G06F19/00 , G06F19/3418
摘要: Systems and methods are described for configuring and using displays, speakers, or other output devices positioned by an article of clothing or other such structure wearable by a healthcare recipient, for example, in a clinic or residential care facility.
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公开(公告)号:US20090157059A1
公开(公告)日:2009-06-18
申请号:US12002304
申请日:2007-12-14
申请人: Paul G. Allen , Edward S. Boyden , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Paul G. Allen , Edward S. Boyden , W. Daniel Hillis , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: A61B17/00
CPC分类号: A61B34/75 , A61B34/20 , A61B34/25 , A61B34/76 , A61B2017/00115 , A61B2017/00119 , A61B2017/00123 , A61B2017/00207 , A61B2017/00221 , A61B2034/105 , A61B2034/107 , A61B2034/256 , A61B2090/365
摘要: The disclosure pertains to a surgical system. In an embodiment, the system comprises one or more sensors operably responsive to physical boundary limitations of an operating field. Furthermore, the one or more sensors provide information regarding the physical boundary limitations of the operating field. In another embodiment, the system comprises a surgical instrument that is configured to respond to the information by either activation or inactivation. In another aspect the disclosure includes generating an anatomical image or anatomic positional reference data from one or more anatomical objects. Additionally, the method includes creating haptic feedback signals based at least partly on the anatomical image or anatomic positional reference data, and determining a position or orientation of a surgical instrument. Furthermore the method includes activating or inactivating the surgical instrument based at least partly on the haptic feedback signals.
摘要翻译: 本公开涉及外科系统。 在一个实施例中,系统包括可操作地响应于操作场的物理边界限制的一个或多个传感器。 此外,一个或多个传感器提供关于操作区域的物理边界限制的信息。 在另一个实施例中,该系统包括被配置为通过激活或失活响应于该信息的外科器械。 在另一方面,本公开包括从一个或多个解剖学对象产生解剖图像或解剖学位置参考数据。 另外,该方法包括至少部分地基于解剖图像或解剖学位置参考数据创建触觉反馈信号,以及确定外科器械的位置或取向。 此外,该方法包括至少部分地基于触觉反馈信号来激活或失活外科器械。
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公开(公告)号:US20100233781A1
公开(公告)日:2010-09-16
申请号:US12322366
申请日:2009-01-30
申请人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: C07C49/00 , C07C69/00 , C07C43/00 , C07C229/00 , C07C47/00 , C07C211/00 , C07C35/00 , C07K16/00 , C07K14/00 , C12N9/10 , C07K2/00 , C07D323/00 , C07H21/04 , C07K14/765 , C07H1/00 , C07D207/40 , C07K14/415 , D01F9/12 , C08G63/91
CPC分类号: C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要: Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
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公开(公告)号:US20100068808A1
公开(公告)日:2010-03-18
申请号:US12322367
申请日:2009-01-30
申请人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
CPC分类号: C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
摘要翻译: 描述了提供靶向脂质双层膜的管状纳米结构或复合管状纳米结构的装置,组合物和方法。 管状纳米结构包括侧面有两个亲水表面区域的疏水表面区域。 管状纳米结构被配置为与脂质双层膜相互作用并在脂质双层膜中形成孔。 管状纳米结构可以通过包括至少一种被配置成结合靶细胞的脂质双层膜上的一个或多个同源物的配体来靶向。
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公开(公告)号:US20100069606A1
公开(公告)日:2010-03-18
申请号:US12283908
申请日:2008-09-15
申请人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: C07K2/00 , C07K16/00 , C07H1/00 , C07H21/04 , C07D323/00 , C07C69/00 , C07C229/00 , C07C49/00 , C07C47/00 , C07C43/00 , C07K14/42
CPC分类号: C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要: Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
摘要翻译: 描述了提供靶向脂质双层膜的管状纳米结构的装置,组合物和方法。 目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域,侧壁有两个亲水性表面区域的疏水性表面区域,所述疏水性表面区域配置成在细胞器官细胞器的脂质双层膜中形成孔,以及至少一个 配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。 靶细胞可以是例如受试者中的肿瘤细胞,感染细胞或患病细胞。 管状纳米结构可以在细胞器(例如线粒体)的脂质双层膜中形成孔,其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。
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公开(公告)号:US20110177154A1
公开(公告)日:2011-07-21
申请号:US12283907
申请日:2008-09-15
申请人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
发明人: Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K.Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC分类号: A61K9/127 , C07K7/64 , C07D321/00 , C07H21/00 , C07K14/00 , C07H7/00 , C07C229/00 , C08G63/48 , C07K16/00 , C12N9/14 , A61K9/14 , A61K38/02 , A61K38/16 , A61K31/335 , A61K31/7088 , A61K38/14 , A61K39/395 , A61K38/12 , A61P43/00 , B82Y5/00
CPC分类号: C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要: Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
摘要翻译: 描述了提供靶向脂质双层膜的管状纳米结构或复合管状纳米结构的装置,组合物和方法。 管状纳米结构包括侧面有两个亲水表面区域的疏水表面区域。 管状纳米结构被配置为与脂质双层膜相互作用并在脂质双层膜中形成孔。 管状纳米结构可以通过包括至少一种被配置成结合靶细胞的脂质双层膜上的一个或多个同源物的配体来靶向。
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