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公开(公告)号：US08948843B2
公开(公告)日：2015-02-03
申请号：US13120854
申请日：2009-10-08
CPC分类号： A61N1/0534 , A61B5/0476 , A61B5/6864 , A61B5/6865 , A61B90/11 , A61N1/0529 , A61N1/08 , A61N1/086
摘要： The invention relates to a probe (10) for an implantable medical device. The probe has a distal end (2) and a proximal end (3), and the probe (10) moreover comprises an electrode (1) at the distal end. The electrode is connected to a wire (5) extending from the electrode to the proximal end of the probe, where the resistivity of the wire is non-uniform along the length of the wire. The wire may have high resistivity at the distal end of the probe and low resistivity wires elsewhere. The high resistivity wires reduce the peak current density in the tissue of an implanted device, and thus prevents destructive heating and/or undesired stimulation of tissue during MRI examination. This highly contributes to MR safety which is a highly desired feature for these implantable electrical stimulation devices.
摘要翻译： 本发明涉及一种用于可植入医疗装置的探针（10）。 探针具有远端（2）和近端（3），并且探针（10）还包括位于远端的电极（1）。 电极连接到从电极延伸到探针的近端的线（5），其中线的电阻率沿着线的长度是不均匀的。 导线在探头的远端可能具有高电阻率，而其他地方的电阻率较低。 高电阻率线降低植入装置的组织中的峰值电流密度，从而防止在MRI检查期间的组织的破坏性加热和/或不期望的刺激。 这高度有助于MR安全性，这是这些可植入电刺激装置的高度期望的特征。
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公开(公告)号：US08818490B2
公开(公告)日：2014-08-26
申请号：US13640517
申请日：2011-03-31
IPC分类号： A61B5/055
CPC分类号： G01R33/28 , A61B5/055 , A61B5/061 , A61B90/11 , A61B90/14 , A61B2017/3405 , A61B2090/061 , A61B2090/374 , A61B2090/3954 , G01R33/286 , G01R33/34046 , G01R33/58
摘要： The invention relates to a preparing apparatus for preparing an influencing procedure for influencing a subject. The preparing apparatus (1) comprises a subject coil (3) for generating a magnetic resonance image of he subject (7), an instrument guide device (5) for guiding an instrument (6) for influencing the subject (7), a marker (9) being visible in the magnetic resonance image, and an attaching element for attaching the instrument guide device (5) to the subject coil (3) in a known spatial relationship. Since the spatial relationship between the instrument guide device (5) and the subject coil (3) is known, if they are attached to each other, a time consuming registration procedure for registering an influence trajectory, which has been planned based on the magnetic resonance image, and the instrument guide device (5) can be avoided.
摘要翻译： 本发明涉及一种用于制定影响对象的影响程序的准备装置。 准备装置（1）包括用于产生被检体（7）的磁共振图像的被检体线圈（3），用于引导用于影响被检体（7）的器械（6）的仪器引导装置（5） （9）在磁共振图像中可见，以及用于以已知的空间关系将仪器引导装置（5）附接到对象线圈（3）的附接元件。 由于仪器引导装置（5）与被检体线圈（3）之间的空间关系是已知的，因此如果它们彼此附接，则基于磁共振计划的用于记录影响轨迹的耗时登记过程 图像和仪器引导装置（5）。
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公开(公告)号：US08568216B2
公开(公告)日：2013-10-29
申请号：US11815017
申请日：2006-01-27
IPC分类号： A63F9/24
CPC分类号： A63F3/02 , A63F3/00643 , A63F2250/265 , A63F2300/1043 , A63F2300/1075
摘要： A pawn (10) for use on a board (21) is provided. The pawn (10) is arranged to provide a trigger signal upon a touch of a triggerable part of the pawn (10) by a user, and comprises communication means for communicating the trigger signal to a board (21). The pawn (10) comprises at least two separate triggerable sub-parts (11, 12) for, upon a touch of each respective one of the at least two separate triggerable sub-parts (11, 12) by a user, respectively providing a first and a second trigger signal. The first and the second trigger signal are mutually distinguishable. Such a pawn (10) can easily be used for activating a certain function of a set of functions. A function is selected by touching a corresponding triggerable sub-part (11, 12).
摘要翻译： 提供了用于板（21）的棋子（10）。 典当（10）被布置为在用户触摸典当（10）的可触发部分时提供触发信号，并且包括用于将触发信号传送到板（21）的通信装置。 典当（10）包括至少两个单独的可触发子部分（11,12），用于在用户触摸所述至少两个可分离的可触发子部件（11,12）中的每个相应的一个时分别提供 第一和第二触发信号。 第一和第二触发信号是相互区分的。 这样的棋子（10）可以容易地用于激活一组功能的某个功能。 通过触摸相应的可触发子部分（11,12）来选择一个功能。
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公开(公告)号：US20100198315A1
公开(公告)日：2010-08-05
申请号：US12667399
申请日：2008-07-03
IPC分类号： A61N1/36
CPC分类号： A61N1/36082
摘要： The invention relates to a neurostimulation system, particularly for deep brain stimulation (DBS), comprising a spatial array (130) of stimulation electrodes (132) and an associated controller (110). The controller (110) is adapted to sequentially supply electrical pulses to different subsets of the stimulation electrodes (132). Preferably, the controller (110) comprises a single pulse-generator (112) and a multiplexing unit (111) for distributing the pulses to different stimulation electrodes. The stimulation electrodes (132) may preferably be arranged on probes (131).
摘要翻译： 本发明涉及神经刺激系统，特别是对于深脑刺激（DBS），其包括刺激电极（132）的空间阵列（130）和相关联的控制器（110）。 控制器（110）适于顺序地向刺激电极（132）的不同子集提供电脉冲。 优选地，控制器（110）包括用于将脉冲分配到不同刺激电极的单个脉冲发生器（112）和多路复用单元（111）。 刺激电极（132）可以优选地布置在探针（131）上。
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公开(公告)号：US20110213382A1
公开(公告)日：2011-09-01
申请号：US13126283
申请日：2009-11-03
申请人： Michel Marcel Jose Decre , Johannes Cornelius Antonius Muller , Michel Gerarous Pardoel , Hubert Cecile Francois Martens
发明人： Michel Marcel Jose Decre , Johannes Cornelius Antonius Muller , Michel Gerarous Pardoel , Hubert Cecile Francois Martens
IPC分类号： A61B19/00
CPC分类号： A61N1/0534 , A61B5/6864 , A61N1/0539
摘要： A device for cranial implantation, comprising a ferrule and a plate for placement in the ferrule is provided. Furthermore, a neurological implant system comprising a probe and a device for cranial implantation is provided.
摘要翻译： 提供了一种用于头部植入的装置，其包括套圈和用于放置在套圈中的板。 此外，提供了包括探针和用于头部植入的装置的神经植入物系统。
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公开(公告)号：US20110082529A1
公开(公告)日：2011-04-07
申请号：US12993261
申请日：2009-05-20
IPC分类号： A61N1/00
CPC分类号： A61N1/0539 , A61M39/0247 , A61M2039/025 , A61N1/0536
摘要： The invention relates to an implantable connection device (100) comprising a porous carrier (120) to which bone tissue (1) can attach and an electrical device that is embedded in the carrier or at least space for such a device. The carrier may particularly comprise ceramic particles, for example a mixture of hydroxyapatite and tricalcium phosphate. The electrical device may consist of one or more feedthrough wires to which leads (11, 21) of external devices can be coupled on both sides of the connection device. The connection device can for example be implemented into the skull (1) of a patient to provide an electrical connection between electrodes in the brain and an external pulse generator.
摘要翻译： 本发明涉及一种可植入连接装置（100），其包括骨组织（1）可以附着的多孔载体（120）和嵌入在载体中的电气装置或至少用于这种装置的空间。 载体可以特别包括陶瓷颗粒，例如羟基磷灰石和磷酸三钙的混合物。 电气设备可以由一个或多个馈通线组成，外部设备的引线（11,21）可以连接到连接装置的两侧。 连接装置可以例如被实施到患者的颅骨（1）中以在脑中的电极和外部脉冲发生器之间提供电连接。
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公开(公告)号：US07328979B2
公开(公告)日：2008-02-12
申请号：US10579154
申请日：2004-11-09
IPC分类号： B41J2/06
CPC分类号： F04B19/006 , B01L3/502792 , B01L2300/089 , B01L2300/161 , B01L2400/0421 , B01L2400/0496 , B08B17/02 , B41J2002/14395
摘要： A system for manipulation of a body of fluid, in particular a fluid droplet comprises several control electrodes to which an adjustable voltage is applied to control displacement of the droplet on the basis of the electrowetting effect. There is a counter electrode having a fixed voltage between the body of fluid and one of the control electrodes. Further, as the counter electrode and the control electrodes are located at the same side of the fluid droplet, the fluid droplet is freely accessible at its side remote from the counter electrode and the control electrodes. Hence, the fluid droplet can be employed as an object carrier and a pay-load can be placed on the droplet from the freely accessible side.
摘要翻译： 用于操纵流体体系，特别是流体液滴的系统包括若干控制电极，其上施加可调节的电压以根据电润湿效应控制液滴的位移。 在液体和其中一个控制电极之间有一个具有固定电压的对电极。 此外，由于对电极和控制电极位于流体液滴的同一侧，所以流体液滴在远离对电极和控制电极的一侧可自由接近。 因此，流体液滴可以用作物体载体，并且付费负载可以从可自由接近的一侧放置在液滴上。
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公开(公告)号：US08688230B2
公开(公告)日：2014-04-01
申请号：US13265408
申请日：2010-04-21
申请人： Michel Gerardus Pardoel , Michel Marcel Jose Decre , Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jozef Elisabeth Franciscus Gootzen , Jeroen Jacob Arnold Tol
发明人： Michel Gerardus Pardoel , Michel Marcel Jose Decre , Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jozef Elisabeth Franciscus Gootzen , Jeroen Jacob Arnold Tol
IPC分类号： A61N1/08
CPC分类号： A61N1/375 , A61N1/0529 , A61N1/0539 , A61N1/37229
摘要： A system (102) comprising a box (104) for implanting in a mammal body part (106), which box is provided with a first electrical contact (110, 121, 114, 116, 118, 120), and a module (108) for accommodating in the box, which module is provided with a second electrical contact (122, 124, 126) for cooperation with said first electrical contact. The first electrical contact and the second electrical contact are mutually movable, at least in a stationary accommodation of the module in the box, between a contact position in which said first and second electrical contacts are electrically connected, and a non-contact position in which said first and second electrical contacts are separated from each other.
摘要翻译： 一种系统（102），包括用于植入哺乳动物体部分（106）中的盒（104），所述盒设置有第一电触头（110,121,114,116,118,120）和模块（108 ），用于容纳在盒中，该模块设置有用于与所述第一电触点配合的第二电触点（122,124,126）。 所述第一电触点和所述第二电接触件至少在所述模块在所述模块的静态容纳部中，在所述第一和第二电触点电连接的触点位置和非接触位置之间， 所述第一和第二电触点彼此分离。
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公开(公告)号：US20130030500A1
公开(公告)日：2013-01-31
申请号：US13581484
申请日：2011-02-25
申请人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
发明人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/00 , A61N1/0534 , A61N1/36185
摘要： A method and a control system (20) are provided for determining a relation between stimulation settings for a brain stimulation probe (10) and a corresponding V-field. The brain stimulation probe (10) comprises multiple stimulation electrodes (11). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (11). The method comprises sequentially applying a test current to n stimulation electrodes (11), n being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), for each test current at one of the n stimulation electrodes (11), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (η)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (11), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
摘要翻译： 提供一种方法和控制系统（20），用于确定脑刺激探针（10）的刺激设置与相应的V场之间的关系。 脑刺激探针（10）包括多个刺激电极（11）。 V场是围绕刺激电极（11）的脑组织中的电场。 所述方法包括对n个刺激电极（11）依次施加测试电流，n是在刺激探针（10）的刺激电极（11）的数量之间的数量，对于在n个刺激之一的每个测试电流 电极（11），根据刺激设置和所测量的激发电压，测量m个刺激电极处的所得激励电压，m为2个与脑刺激探针（10）的刺激电极（11）的数量之间的数字，导出 耦合矩阵中的元素（q，p），反映两个刺激电极（11）之间的电阻抗的量，并且使用用于确定的耦合矩阵 刺激设置与相应V字段之间的关系。
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公开(公告)号：US20100152747A1
公开(公告)日：2010-06-17
申请号：US12600489
申请日：2008-06-03
IPC分类号： A61B17/00
CPC分类号： A61N1/0534
摘要： The present disclosure provides for systems and methods enabling the insertion of leads (as used e.g., in a framework of the brain treatment therapies) through a target anatomy for conforming with a target tissue region. An exemplary lead includes at least a partially curved portion for conforming with a geometry defined by the target tissue region. In an exemplary embodiment, the system relates to stimulating targets in the brain for improved post-operative steering of an applied electric field. The leads can be either pre-curved or put under transversal mechanical strain during insertion such that a certain curved curvature of the insertion trajectory is achieved. The system includes at least a first insertion tool removably engaged with respect to the lead for guiding and providing mechanical support to the lead during insertion.
摘要翻译： 本公开提供了使得能够通过目标解剖结构插入引线（例如在脑治疗疗法的框架中）以插入靶组织区域的系统和方法。 示例性引线包括用于与由目标组织区域限定的几何形状一致的至少部分弯曲部分。 在示例性实施例中，该系统涉及在脑中刺激目标以改善所施加电场的手术后转向。 引线可以在插入过程中预弯曲或放置在横向机械应变下，使得实现插入轨迹的特定弯曲曲率。 该系统至少包括相对于导线可拆卸地接合的第一插入工具，用于在插入期间引导并提供对引线的机械支撑。
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