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公开(公告)号：US20050112673A1
公开(公告)日：2005-05-26
申请号：US10987608
申请日：2004-11-12
申请人： Andrei Laikhter , Mark Behlke , Joseph Walder , Kevin Roberts , Yawfui Yong
发明人： Andrei Laikhter , Mark Behlke , Joseph Walder , Kevin Roberts , Yawfui Yong
IPC分类号： C07C245/10 , C07F9/09 , C07F9/24 , C07H21/04 , C12Q1/68 , C07C331/12
CPC分类号： C09B29/00 , C07C245/10 , C07F9/091 , C07F9/2408 , C07H21/04 , Y10T436/143333
摘要： Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition.
摘要翻译： 公开了一组可用作具有式1的通式结构的荧光猝灭剂的偶氮猝灭剂组合物，制备或使用该组合物的方法，以及包含该组合物的试剂盒。
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公开(公告)号：US07803936B2
公开(公告)日：2010-09-28
申请号：US12623811
申请日：2009-11-23
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
摘要翻译： 本发明提供了一种标记寡核苷酸的新方法，包括但不限于猝灭剂，荧光团，生物素，地高辛，肽和蛋白质。 此外，本发明提供了检测寡核苷酸杂交的方法。 本发明还提供具有下列通式的新型偶氮猝灭剂。 本发明还提供包含标记的寡核苷酸和固体支持物的组合物。 本发明还提供包含至少一种本发明组合物的试剂盒。
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公开(公告)号：US20090299041A1
公开(公告)日：2009-12-03
申请号：US12535220
申请日：2009-08-04
IPC分类号： C09B29/00
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
摘要翻译： 本发明提供了一种标记寡核苷酸的新方法，包括但不限于猝灭剂，荧光团，生物素，地高辛，肽和蛋白质。 此外，本发明提供了检测寡核苷酸杂交的方法。 本发明还提供具有下列通式的新型偶氮猝灭剂。 本发明还提供包含标记的寡核苷酸和固体支持物的组合物。 本发明还提供包含至少一种本发明组合物的试剂盒。
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公开(公告)号：US07605243B2
公开(公告)日：2009-10-20
申请号：US12352125
申请日：2009-01-12
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
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公开(公告)号：US08258276B2
公开(公告)日：2012-09-04
申请号：US13224571
申请日：2011-09-02
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： A compound having the general formula shown below: where R1-6 are independently selected from the group consisting of an electron withdrawing group, an alkyl group, an aryl group, hydrogen, a heteroaryl group, and a five or six member ring structure formed from the R1 and R2 pair, the R3 and R4 pair, the R4 and R5 pair, or the R5 and R6 pair; R7 is a substituted or unsubstituted aryl group; and Y is a nucleophile.
摘要翻译： 具有以下通式的化合物：其中R1-6独立地选自吸电子基团，烷基，芳基，氢，杂芳基和由六个或六元环形成的环结构 R1和R2对，R3和R4对，R4和R5对，或R5和R6对; R7是取代或未取代的芳基; Y是亲核试剂。
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公开(公告)号：US20100298554A1
公开(公告)日：2010-11-25
申请号：US12853741
申请日：2010-08-10
IPC分类号： C07H19/10 , C07C259/00
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： A compound having the general formula shown below: where R1-6 are independently selected from the group consisting of an electron withdrawing group, an alkyl group, an aryl group, hydrogen, a heteroaryl group, and a five or six member ring structure formed from the R1 and R2 pair, the R3 and R4 pair, the R4 and R5 pair, or the R5 and R6 pair; R7 is a substituted or unsubstituted aryl group; and Y is a nucleophile.
摘要翻译： 具有以下通式的化合物：其中R1-6独立地选自吸电子基团，烷基，芳基，氢，杂芳基和由六个或六元环形成的环结构 R1和R2对，R3和R4对，R4和R5对，或R5和R6对; R7是取代或未取代的芳基; Y是亲核试剂。
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公开(公告)号：US07645872B2
公开(公告)日：2010-01-12
申请号：US12535220
申请日：2009-08-04
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
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公开(公告)号：US20110319606A1
公开(公告)日：2011-12-29
申请号：US13224571
申请日：2011-09-02
IPC分类号： C07H21/00
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： A compound having the general formula shown below: where R1-6 are independently selected from the group consisting of an electron withdrawing group, an alkyl group, an aryl group, hydrogen, a heteroaryl group, and a five or six member ring structure formed from the R1 and R2 pair, the R3 and R4 pair, the R4 and R5 pair, or the R5 and R6 pair; R7 is a substituted or unsubstituted aryl group; and Y is a nucleophile.
摘要翻译： 具有以下通式的化合物：其中R1-6独立地选自吸电子基团，烷基，芳基，氢，杂芳基和由六个或六元环形成的环结构 R1和R2对，R3和R4对，R4和R5对，或R5和R6对; R7是取代或未取代的芳基; Y是亲核试剂。
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公开(公告)号：US20100076181A1
公开(公告)日：2010-03-25
申请号：US12623811
申请日：2009-11-23
IPC分类号： C09B29/00
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
摘要翻译： 本发明提供了一种标记寡核苷酸的新方法，包括但不限于猝灭剂，荧光团，生物素，地高辛，肽和蛋白质。 此外，本发明提供了检测寡核苷酸杂交的方法。 本发明还提供具有下列通式的新型偶氮猝灭剂。 本发明还提供包含标记的寡核苷酸和固体支持物的组合物。 本发明还提供包含至少一种本发明组合物的试剂盒。
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公开(公告)号：US08834846B2
公开(公告)日：2014-09-16
申请号：US13101370
申请日：2011-05-05
申请人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
发明人： Tao Ji , Warren M. Leevy , William E. McLaughlin , Yawfui Yong
IPC分类号： A61B5/00
CPC分类号： G01N33/587 , A61K49/0485 , B82Y5/00 , B82Y15/00 , C12Q1/34 , G01N33/542
摘要： Fluorescent activatable probes for imaging biological processes and disease detection in vitro and in vivo. There is also described a method for detecting the presence of an enzyme. A sample is contacted with a nanoparticle including a monomer, at least one cleavable spacer comprising at least one fluorescence activation site, and at least two dyes of at least two types. The cleavable spacer is attached at one end to the nanoparticle. The at least two types comprise an energy donor type and an energy acceptor type. At least one dye of one type is embedded in the nanoparticle and the cleavable spacer has at least one dye of the other type attached. The at least two dyes comprise at least one matched pair capable of fluorescence resonance energy transfer. Fluorescence is detected by exposing the sample to a light source, and detecting emitted light with a detector.
摘要翻译： 用于成像生物过程和体外和体内疾病检测的荧光可激活探针。 还描述了检测酶的存在的方法。 将样品与包含单体的纳米颗粒，至少一个可切割间隔基包含至少一个荧光活化位点和至少两种至少两种类型的染料接触。 可切割间隔物的一端连接到纳米颗粒。 至少两种类型包括能量供体类型和能量受体类型。 至少一种一种染料被包埋在纳米颗粒中，并且可切割间隔物具有至少一种所连接的另一种类型的染料。 所述至少两种染料包含能够进行荧光共振能量转移的至少一个匹配对。 通过将样品暴露于光源并用检测器检测发射光来检测荧光。
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