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公开(公告)号：US20050112673A1
公开(公告)日：2005-05-26
申请号：US10987608
申请日：2004-11-12
申请人： Andrei Laikhter , Mark Behlke , Joseph Walder , Kevin Roberts , Yawfui Yong
发明人： Andrei Laikhter , Mark Behlke , Joseph Walder , Kevin Roberts , Yawfui Yong
IPC分类号： C07C245/10 , C07F9/09 , C07F9/24 , C07H21/04 , C12Q1/68 , C07C331/12
CPC分类号： C09B29/00 , C07C245/10 , C07F9/091 , C07F9/2408 , C07H21/04 , Y10T436/143333
摘要： Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition.
摘要翻译： 公开了一组可用作具有式1的通式结构的荧光猝灭剂的偶氮猝灭剂组合物，制备或使用该组合物的方法，以及包含该组合物的试剂盒。
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公开(公告)号：US08030460B2
公开(公告)日：2011-10-04
申请号：US12853741
申请日：2010-08-10
IPC分类号： C07C245/00 , C12Q1/68 , C07H21/00 , C07H21/02 , C07K16/00
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： A compound having the general formula shown below: where R1-6 are independently selected from the group consisting of an electron withdrawing group, an alkyl group, an aryl group, hydrogen, a heteroaryl group, and a five or six member ring structure formed from the R1 and R2 pair, the R3 and R4 pair, the R4 and R5 pair, or the R5 and R6 pair; R7 is a substituted or unsubstituted aryl group; and Y is a nucleophile.
摘要翻译： 具有以下通式的化合物：其中R1-6独立地选自吸电子基团，烷基，芳基，氢，杂芳基和由六个或六元环形成的环结构 R1和R2对，R3和R4对，R4和R5对，或R5和R6对; R7是取代或未取代的芳基; Y是亲核试剂。
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公开(公告)号：US20090118482A1
公开(公告)日：2009-05-07
申请号：US12352125
申请日：2009-01-12
IPC分类号： C07H21/00
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
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4.发明申请公开(公告)号：US20120064633A1
公开(公告)日：2012-03-15
申请号：US13298479
申请日：2011-11-17
CPC分类号： C09B29/00 , C07C245/10 , C07F9/091 , C07F9/2408 , C07H21/04 , Y10T436/143333
摘要： Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition.
摘要翻译： 公开了一组可用作具有式1的通式结构的荧光猝灭剂的偶氮猝灭剂组合物，制备或使用该组合物的方法，以及包含该组合物的试剂盒。
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公开(公告)号：US07803936B2
公开(公告)日：2010-09-28
申请号：US12623811
申请日：2009-11-23
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
摘要翻译： 本发明提供了一种标记寡核苷酸的新方法，包括但不限于猝灭剂，荧光团，生物素，地高辛，肽和蛋白质。 此外，本发明提供了检测寡核苷酸杂交的方法。 本发明还提供具有下列通式的新型偶氮猝灭剂。 本发明还提供包含标记的寡核苷酸和固体支持物的组合物。 本发明还提供包含至少一种本发明组合物的试剂盒。
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公开(公告)号：US20090299041A1
公开(公告)日：2009-12-03
申请号：US12535220
申请日：2009-08-04
IPC分类号： C09B29/00
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
摘要翻译： 本发明提供了一种标记寡核苷酸的新方法，包括但不限于猝灭剂，荧光团，生物素，地高辛，肽和蛋白质。 此外，本发明提供了检测寡核苷酸杂交的方法。 本发明还提供具有下列通式的新型偶氮猝灭剂。 本发明还提供包含标记的寡核苷酸和固体支持物的组合物。 本发明还提供包含至少一种本发明组合物的试剂盒。
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公开(公告)号：US07605243B2
公开(公告)日：2009-10-20
申请号：US12352125
申请日：2009-01-12
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
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公开(公告)号：US08258276B2
公开(公告)日：2012-09-04
申请号：US13224571
申请日：2011-09-02
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： A compound having the general formula shown below: where R1-6 are independently selected from the group consisting of an electron withdrawing group, an alkyl group, an aryl group, hydrogen, a heteroaryl group, and a five or six member ring structure formed from the R1 and R2 pair, the R3 and R4 pair, the R4 and R5 pair, or the R5 and R6 pair; R7 is a substituted or unsubstituted aryl group; and Y is a nucleophile.
摘要翻译： 具有以下通式的化合物：其中R1-6独立地选自吸电子基团，烷基，芳基，氢，杂芳基和由六个或六元环形成的环结构 R1和R2对，R3和R4对，R4和R5对，或R5和R6对; R7是取代或未取代的芳基; Y是亲核试剂。
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公开(公告)号：US20100298554A1
公开(公告)日：2010-11-25
申请号：US12853741
申请日：2010-08-10
IPC分类号： C07H19/10 , C07C259/00
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： A compound having the general formula shown below: where R1-6 are independently selected from the group consisting of an electron withdrawing group, an alkyl group, an aryl group, hydrogen, a heteroaryl group, and a five or six member ring structure formed from the R1 and R2 pair, the R3 and R4 pair, the R4 and R5 pair, or the R5 and R6 pair; R7 is a substituted or unsubstituted aryl group; and Y is a nucleophile.
摘要翻译： 具有以下通式的化合物：其中R1-6独立地选自吸电子基团，烷基，芳基，氢，杂芳基和由六个或六元环形成的环结构 R1和R2对，R3和R4对，R4和R5对，或R5和R6对; R7是取代或未取代的芳基; Y是亲核试剂。
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公开(公告)号：US07645872B2
公开(公告)日：2010-01-12
申请号：US12535220
申请日：2009-08-04
CPC分类号： C07H21/04 , C07C245/10 , C12Q1/6818
摘要： The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a method of detecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the general formula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.
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