公开(公告)号：US20070259448A1

公开(公告)日：2007-11-08

申请号：US11707385

申请日：2007-02-16

Applicant: David Rissin ,  David Walt

Inventor： David Rissin ,  David Walt

IPC: G01N33/566 ,  C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/581 ,  C12Q1/6837 ,  G01N33/543 ,  G01N33/54346 ,  G01N33/54366 ,  G01N33/54386 ,  G01N2333/938 ,  C12Q2527/143

Abstract: Arrays of single molecules and methods of producing an array of single molecules are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single molecule detection and quantitation.

Abstract translation: 描述单分子阵列和产生单分子阵列的方法。 在10个载体和50个皮升之间具有定义体积的数组使得能够进行单分子检测和定量。

公开(公告)号：US20050196317A1

公开(公告)日：2005-09-08

申请号：US11040504

申请日：2005-01-21

Applicant: David Walt ,  Todd Dickinson

Inventor： David Walt ,  Todd Dickinson

IPC: C12M1/34 ,  C40B60/14 ,  G01N21/64 ,  G01N21/77 ,  G01N33/00 ,  G01N33/543 ,  G01N21/00

CPC classification number: C12Q1/682 ,  B01J2219/00317 ,  B01J2219/0045 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00648 ,  B01J2219/00659 ,  C12Q1/6834 ,  C40B60/14 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/7703 ,  G01N33/0031 ,  G01N33/54313 ,  G01N2201/0846 ,  Y10T436/101666 ,  Y10T436/109163

Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

公开(公告)号：US20050013536A1

公开(公告)日：2005-01-20

申请号：US10855958

申请日：2004-05-28

Applicant: David Walt

Inventor： David Walt

IPC: G02B6/00 ,  G02B6/06 ,  G02B6/26 ,  G02B6/35 ,  G11B20060101 ,  G11B7/00 ,  G11B7/004 ,  G11B7/085 ,  G11B7/135

CPC classification number: G11B7/1384 ,  G11B7/1387 ,  G11B7/24

Abstract: A data storage apparatus includes an array of optical fibers. The array has a first end and a second end. The first end of the array includes multiple optical fiber ends, each optical fiber end having an end face adapted for receiving light of a wavelength λ into the fiber for conveyance to the second end of the fiber array. The second end of the array includes multiple tapered optical fiber tips, each tapered optical fiber end having a minimum diameter less than λ. An opaque coating covers a portion of the tapered optical fiber tips. The data storage apparatus also includes a photochromic medium located within a distance λ of the second end of the array.

Abstract translation: 数据存储装置包括光纤阵列。 阵列具有第一端和第二端。 阵列的第一端包括多个光纤端部，每个光纤端部具有适于将波长λ的光接收到光纤中的端面，用于传送到光纤阵列的第二端。 阵列的第二端包括多个锥形光纤末端，每个锥形光纤端具有小于λ的最小直径。 不透明涂层覆盖锥形光纤尖端的一部分。 数据存储装置还包括位于阵列的第二端的距离λ内的光致变色介质。