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公开(公告)号：US20060286579A1
公开(公告)日：2006-12-21
申请号：US11422045
申请日：2006-06-02
Applicant: Mark Erlander , Xiao-Jun Ma
Inventor： Mark Erlander , Xiao-Jun Ma
CPC classification number: C12Q1/6876 , C12Q2600/158
Abstract: This invention provides gene sequence identities and methods for the determination of cellular gene expression and the comparison of expression levels between different gene sequences and between different cells. The gene sequences may be used as reference, normalization, or “housekeeping” gene sequences, the expression of which remains consistent in individual cells, even under different conditions, as well as among cells from different samples and origins.
Abstract translation: 本发明提供用于确定细胞基因表达的基因序列同一性和方法以及不同基因序列之间和不同细胞之间的表达水平的比较。 基因序列可用作参考，归一化或“家务”基因序列，其表达在单个细胞中甚至在不同条件下以及来自不同样品和来源的细胞中保持一致。
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公开(公告)号：US20060094035A1
公开(公告)日：2006-05-04
申请号：US11145307
申请日：2005-06-03
Applicant: Mark Erlander , Xiao-Jun Ma
Inventor： Mark Erlander , Xiao-Jun Ma
CPC classification number: C12Q1/6886 , C12Q1/6837 , C12Q2600/112 , C12Q2600/158 , G06Q50/22 , G16B25/00 , G16B40/00
Abstract: The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.
Abstract translation: 本发明提供了使用基因表达测量法在临床环境中从受试者获得的样品中分类或鉴定肿瘤的方法，例如在福尔马林固定的石蜡包埋（FFPE）样品的情况下。
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公开(公告)号：US20050208500A1
公开(公告)日：2005-09-22
申请号：US10794263
申请日：2004-03-04
Applicant: Mark Erlander , Xiao-Jun Ma , Wei Wang , James Wittliff
Inventor： Mark Erlander , Xiao-Jun Ma , Wei Wang , James Wittliff
CPC classification number: C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
Abstract: The invention relates to the identification and use of gene expression profiles, or patterns, suitable for identification of populations that are positive and negative for estrogen receptor expression. The gene expression profiles may be embodied in nucleic acid expression, protein expression, or other expression formats, and may be used in the study and/or diagnosis of cells and tissue in breast cancer as well as for the study and/or determination of prognosis of a patient, including breast cancer survival.
Abstract translation: 本发明涉及鉴定和使用适合于鉴定雌激素受体表达阳性和阴性的群体的基因表达谱或模式。 基因表达谱可以体现在核酸表达，蛋白质表达或其他表达形式中，并且可以用于乳腺癌细胞和组织的研究和/或诊断以及用于预后的研究和/或测定 的患者，包括乳腺癌的存活。
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公开(公告)号：US20050095607A1
公开(公告)日：2005-05-05
申请号：US10795092
申请日：2004-03-05
Applicant: Mark Erlander , Xiao-Jun Ma , Wei Wang , James Wittliff
Inventor： Mark Erlander , Xiao-Jun Ma , Wei Wang , James Wittliff
CPC classification number: C07K14/4748 , C12Q1/6837 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
Abstract: The invention relates to the identification and use of gene expression profiles, or patterns, suitable for identification of breast cancer patient populations with different survival outcomes. The gene expression profiles may be embodied in nucleic acid expression, protein expression, or other expression formats, and may be used in the study and/or determination of the prognosis of a patient, including breast cancer survival.
Abstract translation: 本发明涉及鉴定和使用适合于鉴定具有不同生存结果的乳腺癌患者群体的基因表达谱或模式。 基因表达谱可以体现在核酸表达，蛋白质表达或其他表达形式中，并且可以用于研究和/或确定患者的预后，包括乳腺癌存活。
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公开(公告)号：US20050014168A1
公开(公告)日：2005-01-20
申请号：US10769476
申请日：2004-01-30
Applicant: Mark Erlander , Xiao-Jun Ma , Thomas Baer
Inventor： Mark Erlander , Xiao-Jun Ma , Thomas Baer
CPC classification number: C12Q1/6876 , C12Q1/6809 , C12Q1/6851 , C12Q1/686 , C12Q2565/501
Abstract: The invention provides materials and methods for the detection of nucleic acid expression via the 3′ portion of expressed sequences. Embodiments of the invention include the use of microarrays comprising nucleic acid probes that are complementary to the 3′ end of expressed sequences and by the use of quantitative PCR (Q-PCR) based amplification of sequences found at or near the 3′ end of expressed sequences. The invention may be used to detect the presence of expressed nucleic acids encoding particular gene products (sequences present in a “transcriptome”).
Abstract translation: 本发明提供了通过表达序列的3'部分检测核酸表达的材料和方法。 本发明的实施方案包括使用包含与表达的序列的3'末端互补的核酸探针的微阵列，以及通过使用基于定量PCR（Q-PCR）的扩增在3'末端发现的序列的表达 序列。 本发明可用于检测编码特定基因产物（“转录组”中存在的序列）的表达的核酸的存在。
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Patent Agency Ranking
公开(公告)号：US20050009047A1
公开(公告)日：2005-01-13
申请号：US10805171
申请日：2004-03-19
Applicant: Mark Erlander , Ranelle Salunga , Xiao-Jun Ma , Eddy Enright
Inventor： Mark Erlander , Ranelle Salunga , Xiao-Jun Ma , Eddy Enright
CPC classification number: C12Q1/6851 , C12Q2521/119 , C12Q2521/131 , C12Q2521/107 , C12Q2521/101 , C12Q2525/173
Abstract: The present invention provides methods for the amplification of nucleic acid molecules. Methods for amplifying target polynucleotides, including mRNA, using oligonucleotides, DNA and RNA polymerases are provided. The invention further provides compositions and kits for practicing the methods, as well as methods which use the amplification products.
Abstract translation: 本发明提供了扩增核酸分子的方法。 提供了使用寡核苷酸，DNA和RNA聚合酶扩增靶多核苷酸（包括mRNA）的方法。 本发明还提供了用于实施该方法的组合物和试剂盒，以及使用扩增产物的方法。
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公开(公告)号：US20060234287A1
公开(公告)日：2006-10-19
申请号：US11426572
申请日：2006-06-26
Applicant: Mark Erlander , Xia-Jun Ma , Dennis Sgroi
Inventor： Mark Erlander , Xia-Jun Ma , Dennis Sgroi
IPC: C12Q1/68
CPC classification number: G01N33/57415 , C12Q1/6886 , C12Q2600/158 , G01N33/57496 , Y02A90/22
Abstract: Methods and compositions for the identification of breast cancer progression signatures are provided. The signature profiles are identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for identification of cells as being in one or more particular stages of breast cancer.
Abstract translation: 提供了用于鉴定乳腺癌进展特征的方法和组合物。 基于来自独立乳腺癌病例的参考乳腺组织样本的多次取样来识别签名谱，并且提供用于鉴定细胞在乳腺癌的一个或多个特定阶段中的可靠的一组分子标准。
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公开(公告)号：US06413743B1
公开(公告)日：2002-07-02
申请号：US09642855
申请日：2000-08-21
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
IPC: C12N510
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
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公开(公告)号：US20060246434A1
公开(公告)日：2006-11-02
申请号：US10507932
申请日：2003-03-14
Applicant: Mark Erlander , Ranelle Salunga , Theresa Taylor , Liang You , Steven Kunitake
Inventor： Mark Erlander , Ranelle Salunga , Theresa Taylor , Liang You , Steven Kunitake
CPC classification number: C12P19/34 , C12N15/1096 , C12Q1/6846 , C12Q2525/179 , C12Q2525/143 , C12Q2521/107
Abstract: A method of processing images includes the steps of retrieving a source image file including pixel date, creating a destination image file buffer, mapping the pixel data from the source image file to the destination image file buffer, and outputting pixel, data from the destination image file buffer as a destination image file. The step of mapping pixel data from the source image file to the destination image file buffer can include the step of interpolating the source image pixel data to produce pixel date for the destination image file buffer. Border pixel data can be added to the source image file to improve the efficiency interpolation step. The source image file can be a panoramic projection image file, and can include pixel data from a plurality of images. An apparatus for processing images in accordance with the method is also provided.
Abstract translation: 处理图像的方法包括以下步骤：检索包括像素日期的源图像文件，创建目的地图像文件缓冲器，将源图像文件的像素数据映射到目的地图像文件缓冲器，以及从目的地图像输出像素数据 文件缓冲区作为目标映像文件。 将像素数据从源图像文件映射到目的地图像文件缓冲器的步骤可以包括内插源图像像素数据以产生目标图像文件缓冲器的像素日期的步骤。 可以将边缘像素数据添加到源图像文件中，以提高效率插值步骤。 源图像文件可以是全景投影图像文件，并且可以包括来自多个图像的像素数据。 还提供了一种根据该方法处理图像的装置。
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公开(公告)号：US06437100B1
公开(公告)日：2002-08-20
申请号：US09642514
申请日：2000-08-21
Applicant: Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
Inventor： Timothy W. Lovenberg , Mark Erlander , Arne Huvar , Jayashree Pyati
IPC: C07K1628
CPC classification number: C07K14/723 , C12N2799/026
Abstract: DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Abstract translation: 已经克隆并表征了编码人组胺H3受体的DNA。 重组蛋白能够形成生物活性组胺H3受体蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。 重组蛋白也从重组宿主细胞中纯化。 此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。
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