公开(公告)号：US08845674B2

公开(公告)日：2014-09-30

申请号：US13453790

申请日：2012-04-23

申请人： Mark C. Brister ,  Nelson Quintana ,  Kaushik A. Patel ,  Neil R. Drake ,  Antonio C. Llevares ,  Dubravka Markovic ,  Andrew P. Rasdal ,  Amy D. L. VandenBerg

发明人： Mark C. Brister ,  Nelson Quintana ,  Kaushik A. Patel ,  Neil R. Drake ,  Antonio C. Llevares ,  Dubravka Markovic ,  Andrew P. Rasdal ,  Amy D. L. VandenBerg

IPC分类号： A61M29/02 ,  A61F5/00 ,  A61M31/00 ,  A61B17/12 ,  A61B19/00 ,  A61M25/10

CPC分类号： A61F5/003 ,  A61B17/1204 ,  A61B17/12099 ,  A61B90/39 ,  A61B2090/3966 ,  A61F5/0036 ,  A61F5/0073 ,  A61F5/0083 ,  A61L31/088 ,  A61L31/10 ,  A61L2400/16 ,  A61L2420/02 ,  A61L2420/08 ,  A61M25/10185 ,  A61M25/1027 ,  A61M25/1029 ,  A61M31/002 ,  A61M2025/1031 ,  A61M2025/105 ,  Y10T156/1051

摘要： An implant configured for ingestion by a patient. After the implant has been swallowed by the patient and is disposed within the target location, e.g. the patient's stomach, an inflation subcomponent causes the implant to expand from a compact delivery state to an expanded, volume-occupying, deployed state. In the deployed state the implant creates a sensation of satiety in the patient stomach and thereby aids in limiting food intake and obesity. After a predetermined time a deflation subcomponent is actuated and the implant reduces in size so as to allow it to pass through the remainder of the patient's digestive track. The device may further incorporate tracking and visualization subcomponents, as well as pharmaceutical delivery subcomponents.

摘要翻译： 构造成用于由患者摄取的植入物。 在植入物被患者吞咽之后并且被放置在目标位置内，例如， 患者的胃，通气子部件导致植入物从紧凑的递送状态扩展到膨胀的体积占据部署状态。 在部署状态下，植入物在患者胃中产生饱腹感，从而有助于限制食物摄入和肥胖。 在预定时间之后，促使放气次级组件被移动并且植入物的尺寸减小，以便允许其通过病人消化道的其余部分。 该装置还可以包括跟踪和可视化子组件以及药物递送子组件。

公开(公告)号：US20120238852A1

公开(公告)日：2012-09-20

申请号：US13460365

申请日：2012-04-30

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M5/168 ,  A61B5/145

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US20120190953A1

公开(公告)日：2012-07-26

申请号：US13436534

申请日：2012-03-30

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61B5/145

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US08202291B1

公开(公告)日：2012-06-19

申请号：US13069265

申请日：2011-03-22

申请人： Mark C. Brister ,  Andrew P. Rasdal ,  Neil R. Drake ,  Matthew S. Lake ,  Dubravka Markovic ,  Amy D. L. VandenBerg ,  Antonio C. Llevares ,  Josefina Nider

发明人： Mark C. Brister ,  Andrew P. Rasdal ,  Neil R. Drake ,  Matthew S. Lake ,  Dubravka Markovic ,  Amy D. L. VandenBerg ,  Antonio C. Llevares ,  Josefina Nider

IPC分类号： A61M29/00

CPC分类号： A61M29/00 ,  A61F5/0013 ,  A61F5/003 ,  A61F5/0036 ,  A61F5/0073 ,  A61F5/0076 ,  A61M25/10185

摘要： Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of fabricating, deploying, inflating, monitoring, and retrieving the same are provided. The intragastric devices include an intragastric balloon comprising an initial fill gas comprising an inert gas and CO2, a valve system, and a polymeric wall having, under conditions of an in vivo gastric environment, a permeability to CO2 of more than 10 cc/m2/day, such that a rate and an amount of diffusion of CO2 from the in vivo gastric environment into a lumen of the balloon through the polymeric wall is controlled, at least in part, by a concentration of the inert gas and a concentration of CO2 in the initial fill gas, wherein the concentration of CO2 in the initial fill gas is similar to gastric pCO2.

摘要翻译： 提供了治疗肥胖症的装置和方法。 更具体地，提供了胃内装置及其制造，部署，充气，监测和检索方法。 胃内装置包括胃内气囊，其包括包含惰性气体和CO 2的初始填充气体，阀系统和聚合物壁，其在体内胃环境条件下具有大于10cc / m 2 / 天，从而至少部分地通过惰性气体的浓度和二氧化碳的浓度来控制CO 2从体内胃环境扩散通过聚合物壁的球囊腔的速率和量 初始填充气体，其中初始填充气体中的CO 2浓度类似于胃pCO 2。

公开(公告)号：US20090299276A1

公开(公告)日：2009-12-03

申请号：US12536852

申请日：2009-08-06

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M5/168 ,  G06F19/00

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

摘要翻译： 提供了用于集成包括接收器，药物输送装置和任选的单点葡萄糖监测器的连续葡萄糖传感器的系统和方法。 手动集成提供了用户（例如，患者或医生）手动选择数量，类型和/或递送时间的设备之间的物理关联。 设备的半自动化集成包括集成，其中集成组件之间的可操作连接有助于用户（例如患者或医生）在选择，输入，计算或验证葡萄糖值的药物递送量，类型或时间 例如，通过将数据发送到另一个组件，从而减少所需的用户输入量。 设备之间的自动集成包括集成，其中集成组件之间的可操作连接提供对系统的完全控制，而不需要用户交互。

公开(公告)号：US09155843B2

公开(公告)日：2015-10-13

申请号：US13559454

申请日：2012-07-26

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M31/00 ,  A61M1/00 ,  A61M5/315 ,  A61B5/00 ,  A61B5/145 ,  G06F19/00 ,  A61M5/172 ,  A61B5/1486

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US08740927B2

公开(公告)日：2014-06-03

申请号：US13510921

申请日：2011-01-21

申请人： Mark C. Brister ,  Paul D. Faucher ,  Neil R. Drake ,  Andrew P. Rasdal ,  Matthew S. Lake ,  Dubravka Markovic ,  Amy D. L. VandenBerg ,  Antonio C. Llevares ,  Josefina Nider

发明人： Mark C. Brister ,  Paul D. Faucher ,  Neil R. Drake ,  Andrew P. Rasdal ,  Matthew S. Lake ,  Dubravka Markovic ,  Amy D. L. VandenBerg ,  Antonio C. Llevares ,  Josefina Nider

IPC分类号： A61M29/00

CPC分类号： A61F5/003 ,  A61F5/0036 ,  A61F5/0089 ,  A61M25/10181 ,  A61M25/10185 ,  A61M29/02

摘要： Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of fabricating, deploying, inflating, monitoring, and retrieving the same are provided.

公开(公告)号：US08647358B2

公开(公告)日：2014-02-11

申请号：US13011842

申请日：2011-01-21

申请人： Mark C. Brister ,  Paul D. Faucher ,  Neil R. Drake ,  Andrew P. Rasdal ,  Matthew S. Lake ,  Dubravka Markovic ,  Amy D. L. VandenBerg ,  Antonio C. Llevares ,  Josefina Nider

发明人： Mark C. Brister ,  Paul D. Faucher ,  Neil R. Drake ,  Andrew P. Rasdal ,  Matthew S. Lake ,  Dubravka Markovic ,  Amy D. L. VandenBerg ,  Antonio C. Llevares ,  Josefina Nider

IPC分类号： A61M29/00

CPC分类号： A61F5/0089 ,  A61F5/003 ,  A61F5/0036 ,  A61F5/0043 ,  A61F2005/0016 ,  A61M25/1011 ,  A61M25/10182 ,  A61M25/10184 ,  A61M25/10185 ,  A61M25/10186 ,  A61M25/10187 ,  A61M2025/1054 ,  A61M2025/1081

摘要： Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of fabricating, deploying, inflating, monitoring, and retrieving the same are provided.

摘要翻译： 提供了治疗肥胖症的装置和方法。 更具体地，提供了胃内装置及其制造，部署，充气，监测和检索方法。

公开(公告)号：US20120265234A1

公开(公告)日：2012-10-18

申请号：US13453790

申请日：2012-04-23

申请人： Mark C. Brister ,  Nelson Quintana ,  Kaushik A. Patel ,  Neil R. Drake ,  Antonio C. Llevares ,  Dubravka Markovic ,  Andrew P. Rasdal ,  Amy D.L. VandenBerg

发明人： Mark C. Brister ,  Nelson Quintana ,  Kaushik A. Patel ,  Neil R. Drake ,  Antonio C. Llevares ,  Dubravka Markovic ,  Andrew P. Rasdal ,  Amy D.L. VandenBerg

IPC分类号： A61F2/04 ,  B29C65/48

CPC分类号： A61F5/003 ,  A61B17/1204 ,  A61B17/12099 ,  A61B90/39 ,  A61B2090/3966 ,  A61F5/0036 ,  A61F5/0073 ,  A61F5/0083 ,  A61L31/088 ,  A61L31/10 ,  A61L2400/16 ,  A61L2420/02 ,  A61L2420/08 ,  A61M25/10185 ,  A61M25/1027 ,  A61M25/1029 ,  A61M31/002 ,  A61M2025/1031 ,  A61M2025/105 ,  Y10T156/1051

摘要： An implant configured for ingestion by a patient. After the implant has been swallowed by the patient and is disposed within the target location, e.g. the patient's stomach, an inflation subcomponent causes the implant to expand from a compact delivery state to an expanded, volume-occupying, deployed state. In the deployed state the implant creates a sensation of satiety in the patient stomach and thereby aids in limiting food intake and obesity. After a predetermined time a deflation subcomponent is actuated and the implant reduces in size so as to allow it to pass through the remainder of the patient's digestive track. The device may further incorporate tracking and visualization subcomponents, as well as pharmaceutical delivery subcomponents.

摘要翻译： 构造成用于由患者摄取的植入物。 在植入物被患者吞咽之后并且被放置在目标位置内，例如， 患者的胃，通气子部件导致植入物从紧凑的递送状态扩展到膨胀的体积占据部署状态。 在部署状态下，植入物在患者胃中产生饱腹感，从而有助于限制食物摄入和肥胖。 在预定时间之后，促使放气次级组件被移动并且植入物的尺寸减小，以便允许其通过病人消化道的其余部分。 该装置还可以包括跟踪和可视化子组件以及药物递送子组件。

公开(公告)号：US20120186581A1

公开(公告)日：2012-07-26

申请号：US13436257

申请日：2012-03-30

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M5/168 ,  A61M15/00 ,  A61M11/00 ,  A61M35/00

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.