公开(公告)号：US09848809B2

公开(公告)日：2017-12-26

申请号：US13446983

申请日：2012-04-13

申请人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

发明人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

IPC分类号： A61B5/1495 ,  A61B5/1486 ,  A61B5/1473 ,  G01D18/00 ,  G01N33/49 ,  G01N27/327 ,  A61B5/145 ,  A61B5/00 ,  G01N27/02

CPC分类号： A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49

摘要： Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US09237864B2

公开(公告)日：2016-01-19

申请号：US12829306

申请日：2010-07-01

申请人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

发明人： Peter C. Simpson ,  Robert Boock ,  Paul V. Neale ,  Sebastian Bohm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC分类号： A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

CPC分类号： A61B5/1473 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B2560/0223 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/125 ,  B05C3/10

摘要： Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

公开(公告)号：US09149220B2

公开(公告)日：2015-10-06

申请号：US13446977

申请日：2012-04-13

申请人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

发明人： Sebastian Bohm ,  Daiting Rong ,  Peter C. Simpson

IPC分类号： G08B21/00 ,  A61B5/1495 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00

CPC分类号： A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49

摘要： Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

摘要翻译： 提供了用于处理传感器数据和自校准的系统和方法。 在一些实施例中，提供了能够基于初始灵敏度来校准连续分析物传感器，然后在不使用或减少使用参考测量的情况下连续执行自校准的系统和方法。 在某些实施例中，通过应用作为某些参数的函数的估计算法来确定分析物传感器的灵敏度。 本文还描述了使用刺激信号来确定分析物传感器的性质的系统和方法。 传感器属性可用于补偿传感器数据的灵敏度漂移，或确定与传感器相关的其他属性，如温度，传感器膜损坏，传感器电子设备中的水分进入以及缩放因子。

公开(公告)号：US08929968B2

公开(公告)日：2015-01-06

申请号：US12838691

申请日：2010-07-19

申请人： Mark C. Brister ,  James R. Petisce ,  Peter C. Simpson

发明人： Mark C. Brister ,  James R. Petisce ,  Peter C. Simpson

IPC分类号： A61B5/05 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1486 ,  A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/742 ,  A61B2560/0223 ,  B33Y70/00 ,  B33Y80/00

摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.

摘要翻译： 本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干涉域。

公开(公告)号：US08474397B2

公开(公告)日：2013-07-02

申请号：US12775315

申请日：2010-05-06

申请人： Mark Brister ,  James R. Petisce ,  Sean Saint ,  Kum Ming Woo ,  Victor Ha ,  John Nolting ,  Peter C. Simpson ,  James Brauker

发明人： Mark Brister ,  James R. Petisce ,  Sean Saint ,  Kum Ming Woo ,  Victor Ha ,  John Nolting ,  Peter C. Simpson ,  James Brauker

IPC分类号： B05C5/00 ,  B05D3/00

CPC分类号： A61B5/14532 ,  A61B5/0002 ,  A61B5/0004 ,  A61B5/05 ,  A61B5/14 ,  A61B5/1411 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14507 ,  A61B5/14514 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/6801 ,  A61B5/6832 ,  A61B5/6833 ,  A61B5/6848 ,  A61B5/6849 ,  A61B5/72 ,  A61B17/3468 ,  A61B2017/3492 ,  A61B2560/0223 ,  A61B2560/045 ,  A61M5/14 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1585 ,  G06F19/00 ,  Y02A90/26

摘要： The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

公开(公告)号：US08460231B2

公开(公告)日：2013-06-11

申请号：US13180396

申请日：2011-07-11

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv U. Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M31/00 ,  A61M1/00

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US08428678B2

公开(公告)日：2013-04-23

申请号：US13473352

申请日：2012-05-16

申请人： Apurv Ullas Kamath ,  Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode, Jr.

发明人： Apurv Ullas Kamath ,  Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode, Jr.

IPC分类号： A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/742 ,  A61B2560/0223 ,  B33Y70/00 ,  B33Y80/00

摘要： Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.

公开(公告)号：US08425417B2

公开(公告)日：2013-04-23

申请号：US12267494

申请日：2008-11-07

申请人： Jacob S. Leach ,  Peter C. Simpson

发明人： Jacob S. Leach ,  Peter C. Simpson

IPC分类号： A61B5/00

CPC分类号： A61B5/14865 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/6848 ,  A61B5/6849 ,  A61B2560/0223 ,  A61M5/14 ,  A61M5/16804 ,  A61M5/1723 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H40/40 ,  Y02A90/26

摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system and the simultaneous control of a flow control device are provided. In some embodiments, an integrated system includes a vascular access device, a continuous analyte sensor, system electronics and an electronic cable for communication with a third-party infusion device, the system being configured for insertion into fluid communication with a host's circulatory system.

摘要翻译： 提供了用于宿主血管系统的连续分析物测量的系统和方法以及流量控制装置的同时控制。 在一些实施例中，集成系统包括血管通路装置，连续分析物传感器，系统电子装置和用于与第三方输注装置通信的电子电缆，所述系统被配置为插入与主机的循环系统的流体连通。

公开(公告)号：US08423114B2

公开(公告)日：2013-04-16

申请号：US11865572

申请日：2007-10-01

申请人： Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

发明人： Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6849 ,  C12Q1/006

摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.

摘要翻译： 本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用第一和第二工作电极来测量附加分析物或非分析物相关信号。 这样的测量可以提供用于处理传感器数据的背景和/或灵敏度测量，并且可以用于触发诸如数据的数字滤波或暂停显示数据的事件。

公开(公告)号：US08364230B2

公开(公告)日：2013-01-29

申请号：US12055227

申请日：2008-03-25

申请人： Peter C. Simpson ,  Mark Brister ,  Jacob S. Leach

发明人： Peter C. Simpson ,  Mark Brister ,  Jacob S. Leach

IPC分类号： A61B5/00

CPC分类号： A61B5/1495 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/412 ,  A61B5/6848 ,  A61B5/6849 ,  A61B6/586 ,  A61B2560/0223 ,  A61M5/14 ,  A61M5/16804 ,  A61M2230/201 ,  C12Q1/001 ,  C12Q1/006 ,  G06F19/3468 ,  G16H40/40 ,  Y02A90/26

摘要： Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.